全文获取类型
收费全文 | 2898篇 |
免费 | 225篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 59篇 |
儿科学 | 139篇 |
妇产科学 | 37篇 |
基础医学 | 429篇 |
口腔科学 | 113篇 |
临床医学 | 274篇 |
内科学 | 635篇 |
皮肤病学 | 117篇 |
神经病学 | 105篇 |
特种医学 | 85篇 |
外科学 | 402篇 |
综合类 | 133篇 |
一般理论 | 1篇 |
预防医学 | 103篇 |
眼科学 | 46篇 |
药学 | 182篇 |
1篇 | |
中国医学 | 22篇 |
肿瘤学 | 263篇 |
出版年
2023年 | 16篇 |
2022年 | 34篇 |
2021年 | 57篇 |
2020年 | 48篇 |
2019年 | 42篇 |
2018年 | 72篇 |
2017年 | 48篇 |
2016年 | 68篇 |
2015年 | 70篇 |
2014年 | 112篇 |
2013年 | 124篇 |
2012年 | 220篇 |
2011年 | 214篇 |
2010年 | 99篇 |
2009年 | 104篇 |
2008年 | 172篇 |
2007年 | 191篇 |
2006年 | 161篇 |
2005年 | 162篇 |
2004年 | 143篇 |
2003年 | 126篇 |
2002年 | 102篇 |
2001年 | 81篇 |
2000年 | 85篇 |
1999年 | 80篇 |
1998年 | 25篇 |
1997年 | 24篇 |
1996年 | 26篇 |
1995年 | 17篇 |
1994年 | 20篇 |
1993年 | 11篇 |
1992年 | 31篇 |
1991年 | 37篇 |
1990年 | 26篇 |
1989年 | 26篇 |
1988年 | 19篇 |
1987年 | 38篇 |
1986年 | 13篇 |
1985年 | 27篇 |
1984年 | 17篇 |
1983年 | 9篇 |
1980年 | 9篇 |
1979年 | 14篇 |
1978年 | 9篇 |
1976年 | 8篇 |
1975年 | 12篇 |
1974年 | 11篇 |
1972年 | 9篇 |
1971年 | 13篇 |
1966年 | 9篇 |
排序方式: 共有3146条查询结果,搜索用时 15 毫秒
41.
Kikkeri Narayanashetty Naveen Varadraj V. Pai Praveen Bagalkot Vijay Kulkarni Priyanka Rashme Sharatchandra B. Athanikar 《Nutrition (Burbank, Los Angeles County, Calif.)》2013,29(11-12):1426-1428
This case has been presented as pellagra, which is very rare in children. Pellagra is due dietary deficiency of niacin. Usually seen in alcoholics, malabsorption syndromes occur very rarely in children. A 11-y-old girl presented with well-defined, hyperpigmented, hyperkeratotic, symmetrical, thick scaly plaques surrounded by erythema on the dorsum of the hands, arms, feet, legs up to knees, and along the sides of the neck. The child was given 100 mg of Nicotinamide. Skin lesions resolved rapidly with the treatment and the child improved. 相似文献
42.
43.
44.
Ahmed M. Shafter M.D. Ashish Mukherjee M.D. Prabhdeep Sethi M.D. Ramdas G. Pai M.D. 《Echocardiography (Mount Kisco, N.Y.)》2016,33(5):799-801
Isolated congenital left ventricular diverticulum (LV) is reportedly a rare finding. It is frequently associated with other congenital defects involving heart, pericardium, sternum, diaphragm, and abdominal wall. It is an outpouching from the ventricle and has all three layers of left ventricular free walls. We present the case of a 53‐year‐old woman who was discovered to have an outpouching of the LV apex on a nongated chest CT scan raising possibility of a pseudoaneurysm. A transesophageal echocardiogram (TEE) showed systolic diminution of this outpouching with unique Doppler flow‐patterns suggesting a diagnosis of a muscular type of LV diverticulum instead of a postinfarct LV pseudoaneurysm. The patient was reassured and treated conservatively. 相似文献
45.
46.
47.
S. E. Soh M. Aw I. Gerez Y. S. Chong M. Rauff Y. P. M. Ng H. B. Wong N. Pai B. W. Lee L. P.-C. Shek 《Clinical and experimental allergy》2009,39(4):571-578
Background The role of probiotics in allergy prevention remains uncertain but has been shown in some studies to have a possible protective effect on eczema. Objective We aimed to assess the effect of probiotic supplementation in the first 6 months of life on eczema and allergic sensitization at 1 year of age in Asian infants at risk of allergic disease. Methods A double‐blind, placebo‐controlled randomized clinical trial involving 253 infants with a family history of allergic disease was carried out. Infants received at least 60 mL of commercially available cow's milk formula with or without probiotic supplementation [Bifidobacterium longum (BL999) 1 × 107 colony forming unit (CFU)/g and Lactobacillus rhamnosus (LPR) 2 × 107 CFU/g] daily for the first 6 months. Clinical evaluation was performed at 1, 3, 6 and 12 months of age, with serum total IgE measurement and skin prick tests conducted at the 12‐month visit. The primary and secondary end‐points were eczema and allergen sensitization, respectively. Results The incidence of eczema in the probiotic (22%) group was similar to that in the placebo group (25%) (P=0.53). The median Scoring Atopic Dermatitis score at 12 months was 17.10 (9.74) in the probiotic group and 11.60 (8.40) in the placebo group (P=0.17). The prevalence of allergen sensitization showed no difference (probiotic=24% vs. placebo=19%, P=0.26). The total IgE geometric mean (95% confidence interval) was 18.76 (12.54–24.98) kU/L in the probiotic group and 23.13 (16.01–30.24) kU/L in the placebo group (P=0.15). Atopic eczema (with sensitization) in the probiotic (7.3%) group was comparable to the placebo group (5.8%) (P=0.86). Conclusion Early life administration of a cow's milk formula supplemented with probiotics showed no effect on prevention of eczema or allergen sensitization in the first year of life in Asian infants at risk of allergic disease. Further work is needed to determine whether timing of supplementation, dose and probiotic strain are important considerations. 相似文献
48.
Jeffrey J. Talbot Dominador Calamba Melody Pai Mark Ma Theingi M. Thway 《The AAPS journal》2015,17(6):1446-1454
Decisions about efficacy and safety of therapeutic proteins (TP) designed to target soluble ligands are made in part by their ex vivo quantification. Ligand binding assays (LBAs) are critical tools in measuring serum TP levels in pharmacokinetic, toxicokinetic, and pharmacodynamic studies. This study evaluated the impact of reagent antibody affinities, assay incubation times, and analytical platform on free or total TP quantitation. An ELISA-based LBA that measures monoclonal anti-sclerostin antibody (TPx) was used as the model system. To determine whether the method measures free or total TPx, the effects of Kon, Koff, and KD were determined. An 8:1 molar ratio of sclerostin (Scl) to TPx compared to a 1:1 molar ratio produced by rabbit polyclonal antibodies to TPx was required to achieve IC50, a measure of TPx interference effectiveness, making it unclear whether the ELISA truly measured free TPx. Kinetic analysis revealed that Scl had a rapid dissociation rate (Koff) from TPx and that capture and detection antibodies had significantly higher binding affinities (KD) to TPx. These kinetic limitations along with long ELISA incubation times lead to the higher molar ratios (8:1) required for achieving 50% inhibition of TPx. However, a microfluidic platform with the same reagent pairs required shorter incubations to achieve a lower Scl IC50 molar ratio (1:1). The findings from this study provide the bioanalytical community with a deeper understanding of how reagent and platform selection for LBAs can affect what a particular method measures, either free or total TP concentrations.KEY WORDS: affinity and kinetics, association and dissociation, free versus total, interference, ligand binding assay 相似文献
49.
Lumbrokinase from earthworm extract ameliorates second‐hand smoke‐induced cardiac fibrosis
下载免费PDF全文
![点击此处可从《Environmental toxicology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
50.
Se Jin Park Ki Soo Pai Jun Mo Kim Kwanjin Park Kun Suk Kim Sang Hoon Song Sungchan Park Sun-Ouck Kim Dong Soo Ryu Minki Baek Sang Don Lee Jung Won Lee Young Jae Im Sang Won Han Jae Min Chung Min Hyun Cho Tae-Sun Ha Won Yeol Cho Hong Jin Suh The Korean Children's Continence Enuresis Society 《Journal of Korean medical science》2015,30(1):119