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Penny F Whiting Marie E Weswood Anne WS Rutjes Johannes B Reitsma Patrick NM Bossuyt Jos Kleijnen 《BMC medical research methodology》2006,6(1):1-8
Background
In clinical trials, both unequal randomization design and sequential analyses have ethical and economic advantages. In the single-stage-design (SSD), however, if the sample size is not adjusted based on unequal randomization, the power of the trial will decrease, whereas with sequential analysis the power will always remain constant. Our aim was to compare sequential boundaries approach with the SSD when the allocation ratio (R) was not equal. 相似文献43.
44.
Grüntzig balloon catheters were used to dilate ten esophageal strictures in eight infants and children. Five infants who had anastomotic strictures following esophageal atresia repair gained complete resolution of their strictures, usually after one or two dilatations. Three older children who had strictures following esophageal re-operation or reconstruction required longer courses of dilatations to achieve consistent esophageal patency. The technique failed in two chronic strictures of two and one-half and nine years' duration. Balloon catheter dilatation, begun in the early postoperative period, is a safe, effective method for dilating esophageal strictures. 相似文献
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A 1985 general population survey was conducted by Gallup in Great Britain. Subjects (4,148) were questioned about their use of benzodiazepines of whom 1,284 were also questioned about their alcohol, cigarette and caffeine consumption. Data were examined to find possible multiple substance misuse. No strong evidence could be found. People taking benozodiazepines at the time of the survey consumed significantly less alcohol than non-users or past users. Cigarette consumption was found to be increased in current and past benzodiazepine users. Subgroups of benzodiazepine users, defined as‘high users’,‘dosage escalators’or‘chronic users’were also examined. Again no strong evidence of multiple substance misuse could be found. However, high users and dosage escalators did smoke more than others. Concurrent misuse of benzodiazepines and other legally available psychoactive substances is not common in the general population. 相似文献
47.
Rob JEM Smeets Johan WS Vlaeyen Alita Hidding Arnold DM Kester Geert JMG van der Heijden Antonia CM van Geel J André Knottnerus 《BMC musculoskeletal disorders》2006,7(1):5-16
Background
The treatment of non-specific chronic low back pain is often based on three different models regarding the development and maintenance of pain and especially functional limitations: the deconditioning model, the cognitive behavioral model and the biopsychosocial model. 相似文献48.
49.
Cyclic vomiting syndrome in South-East Asian children 总被引:3,自引:0,他引:3
50.