Association between Geriatric Nutritional Risk Index and Depression after Ischemic Stroke

Background: Malnutrition is associated with poor outcomes after stroke. However, the association between malnutrition and post-stroke depression (PSD) remains unelucidated. We aimed to explore the association between geriatric nutritional risk index (GNRI) and depression after ischemic stroke. Methods: In total, 344 patients with ischemic stroke were included in this analysis. The GNRI was calculated from serum albumin level, weight, and height at admission. Malnutrition was defined using the GNRI cutoff points. A lower GNRI score indicates an elevated nutritional risk. The outcome was depression, measured 14 days after ischemic stroke. Logistic regression models were used to estimate the association between the GNRI and risk of PSD. Results: A total of 22.9% developed PSD 14 days after stroke. The mean GNRI was 99.3 ± 6.0, and 53.8% of the patients had malnutrition. After adjusting for covariates, baseline malnutrition was not associated with risk of PSD (OR, 0.670; 95%CI, 0.370–1.213; p = 0.186). The restricted cubic splines revealed a U-shaped association between the GNRI and PSD. Compared to moderate GNRI, higher GNRI (OR, 2.368; 95%CI, 0.983–5.701; p = 0.085) or lower GNRI (OR, 2.226; 95%CI, 0.890–5.563; p = 0.087) did not significantly increase the risk of PSD. Conclusion: A low GNRI was not associated with an increased risk of depression after ischemic stroke.     

超声引导下腹部神经阻滞对老年患者术后疼痛及认知状态的影响

目的：探讨超声引导下腹部神经阻滞对老年患者术后疼痛及认知状态的影响。方法：回顾性分析本院2017年4月～2020年4月收治的80例老年腹部手术患者,根据镇痛模式的选择分为全麻-神经阻滞组(44例)和全麻组(36例)。比较两组的术中情况(麻醉时间、手术时间、术中出血量)、术后24 h内舒芬太尼自控镇痛用量与追加次数、术后24 h和术后48 h的静息状态与运动状态下疼痛程度(VAS疼痛评分)、入室时和术后24 h的血清细胞白介素6(IL-6)、超敏-C反应蛋白(Hs-CRP)水平、术后7 d内POCD发生率和不良反应发生率。结果：两组患者麻醉时间、手术时间、术中出血量的差异均无统计学意义;全麻-神经阻滞组患者的24 h内舒芬太尼用量、追加次数、术后24 h和48 h的静息疼痛评分和运动疼痛评分均低于全麻组;两组患者术后24 h的血清IL-6、Hs-CRP均较入室时升高,全麻-神经阻滞组术后24 h的血清IL-6、Hs-CRP低于全麻组;两组患者术后POCD发生率和不良反应总发生率无明显差异。结论：全麻-神经阻滞继以静脉自控镇痛用于老年腹部手术患者的镇痛效果优于全麻继以静脉自控镇痛,舒芬太尼...     

Research on Dynamic Compressive Performance and Failure Mechanism Analysis of Concrete after High Temperature and Rapid Cooling

To investigate the dynamic compressive properties of concrete after high temperature and rapid cooling, an experimental study was carried out by considering five temperatures and four strain rates. The coupling effect of high temperature and strain rate on concrete damage morphology and mechanical parameters was comparatively analyzed. The main conclusions are as follows: the compressive damage morphology of concrete is affected by strain rate development trends of significant variability under different temperature conditions. As the strain rate increases, the compressive stress and elastic modulus of concrete are gradually increased. As the temperature increases, the increase in compressive stress is gradually reduced by the strain rate. For the temperatures of 20 °C and 800 °C, the increase in compressive stress by the strain rate is 38.69% and 7.78%, respectively. Meanwhile, SEM and CT scanning technology were applied to examine the mechanism of the effect of high temperature and strain rate on the mechanical properties of concrete from the microscopic perspective, and the corresponding constitutive model was proposed.     

新型三维外固定架系统联合内固定治疗Gustilo Ⅲ型胫腓骨开放性骨折的疗效分析

目的 探讨一期新型三维创伤外固定架系统联合二期内固定治疗Gustilo Ⅲ型胫腓骨开放性骨折的临床效果.方法 收集中国人民解放军联勤保障部队第989医院自2018年6月至2020年1月间收治的40例Gustilo Ⅲ型胫腓骨开放性骨折的患者作为研究对象,随机分为观察组和对照组.观察组(20例)一期采用三维创伤外固定架系...     

2013-2017年新疆伊犁州艾滋病母婴传播现状分析

目的 了解新疆伊犁州2013-2017年艾滋病母婴传播发生情况,探讨母婴传播的影响因素,为今后工作提供参考.方法 收集2013-2017年新疆伊犁州HIV感染孕产妇及所分娩婴幼儿的相关信息.通过描述性分析,x2检验了解HIV感染孕产妇及婴幼儿的一般特征,采用多因素logistic回归分析法,对HIV母婴传播的影响因素进...     

5-氨基酮戊酸光动力治疗基底细胞癌疗效评价

目的:评价5-氨基酮戊酸光动力(ALA-PDT)治疗基底细胞癌的疗效及安全性.方法:回顾2016-2019年我院进行ALA-PDT治疗的17例基底细胞癌患者(浅表型14例,结节型3例)的临床资料.结果:14例浅表型基底细胞癌患者中13例患者皮损消退,仅留轻微色素沉着或色素减退,2例复发,1例于治疗后6个月后复发,1例于...     

肥胖与中医体质相关研究进展

近几十年来,肥胖成为了一个全球性的公共卫生问题,采取有效的手段干预肥胖显得尤为重要。研究表明肥胖与中医体质有着紧密的关联。现从古籍中肥胖与体质的相关论述,肥胖人群的体质分布特点,不同体质肥胖人群的相关指标研究,对肥胖人群进行干预的效果等几个方面进行综述,以对肥胖与中医体质的相关研究进行归纳总结,为后续研究的开展提供参考。     

不同界值诊断的单纯舒张期高血压与颈动脉内膜中层厚度的关系

目的 探讨不同界值诊断的单纯舒张期高血压(IDH)与颈动脉内膜中层厚度(CIMT)的关系。方法 以开滦研究队列中参加2010年体检及后续随访,且接受了颈动脉超声检查者23 622人作为观察对象。分别参照我国高血压防治指南和2017年美国心脏病学会(ACC)/美国心脏协会(AHA)高血压管理指南标准将研究对象分为4组：正常血压组、IDH组、单纯收缩期高血压(ISH)组和收缩舒张期高血压(SDH)组。采用多因素logistic回归分析总人群和不同年龄段不同标准IDH对CIMT的影响。结果 最终入选研究对象21 649人。按照中国高血压防治指南和2017年ACC/AHA高血压管理指南标准,IDH组人群分别为938例(4.3%)和2 815例(13.0%),IDH组CIMT增厚人群分别为202例(21.5%)和410例(14.6%)。以CIMT是否增厚为因变量,分别以两种标准定义的高血压分组为自变量代入多因素logistic回归模型,在校正了多种混杂因素后,结果显示,两种标准诊断的IDH均与CIMT增厚不相关(P>0.05)。分层分析显示,我国高血压防治指南标准诊断的IDH是年龄<...     

生长激素释放激素受体激动剂MR409减轻糖尿病Db/Db小鼠血管钙化

目的 研究生长激素释放激素受体激动剂MR409对基因缺陷小鼠Db/Db糖尿病小鼠(Db/Db小鼠)血管钙化(VC)的保护作用.方法 以12周龄雄性野生型(WT) C57 BL/6小鼠为WT组(对照组),12周龄雄性Db/Db小鼠随机分为Db/Db组(糖尿病组)和MR409组(MR409治疗组).MR409组隔天给予MR...