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501.
Hepatitis C virus infection in the elderly 总被引:1,自引:0,他引:1
Brind AM; Watson JP; James OF; Bassendine MF 《QJM : monthly journal of the Association of Physicians》1996,89(4):291-296
We studied hepatitis C virus (HCV)-related disease in older people because
the treatment rationale for younger asymptomatic patients is based on the
long-term prognosis of infection. Of the HCV-antibody-positive patients
seen at Freeman Hospital 1990-1994, 25 were >65 years old; 24 were
Caucasian and one was Afro-Caribbean. Median age at presentation was 67
years, and five were female. Nine were asymptomatic at presentation, six
presented with varices, five with malaise, three with abdominal pain one
with pruritis and one with oedema. Risk factors identified were:
transfusion (7), haemodialysis (1), health care worker (dentist) (1), and
tattoos (2). There was no recognized risk factor for infection in 14, but
five of these had done military service in areas of high HCV prevalance.
Liver biopsy in 20 showed chronic hepatitis in two, cirrhosis in 12, and
cirrhosis and hepatocellular carcinoma in six. Three additional patients
also developed hepatocellular carcinoma. HCV genotyping was done in 19 and
all were type 1 (1a, 4; 1b, 14; 1 untypable, 1). Eleven died, at median age
71 years (range 65-94 years), five of HCV liver-related deaths and two from
HCV-associated non hepatic disorders (non-Hodgkin's lymphoma and fibrosing
alveolitis).
相似文献
502.
Velardi A; Terenzi A; Cucciaioni S; Millo R; Grossi CE; Grignani F; Martelli MF 《Blood》1988,71(5):1196-1200
Peripheral blood T cell subsets were evaluated in 11 patients during the reconstitution phase after allogeneic bone marrow transplantation and compared with 11 age-matched controls. The proportion of cells coexpressing Leu7 and CD11b (C3bi receptor) markers was determined within the CD4+ (T-helper) and the CD8+ (T-suppressor) subsets by two- color immunofluorescence analysis. CD4+ and CD8+ T cells reached normal or near-normal values within the first year posttransplant. In contrast to normal controls, however, most of the cells in both subsets coexpressed the Leu7 and CD11b markers. T cells with such phenotype display the morphological features of granular lymphocytes (GLs) and a functional inability to produce interleukin 2 (IL 2). These T cell imbalances were not related to graft v host disease (GvHD) or to clinically detectable virus infections and may account for some defects of cellular and humoral immunity that occur after bone marrow transplantation. 相似文献
503.
The clinical and radiographic findings in 29 patients presenting with pulmonary sarcoidosis after the age of 50 years were reviewed. Fifty-nine percent (17 patients) had atypical findings at presentation. The atypical patterns at radiography included mediastinal adenopathy alone or in combination with unilateral hilar adenopathy (n = 8), solitary or multiple pulmonary masses (n = 3), and atelectasis (n = 3). Five patients had extrathoracic tumors at the time that the diagnosis of pulmonary sarcoidosis was made, which confused the diagnosis at radiography. An enhanced awareness of the atypical patterns of sarcoidosis in the older patient may facilitate the diagnostic process. 相似文献
504.
Falini B; Flenghi L; Fagioli M; Martelli MF; Pileri S; Grignani F; Beltrami A; Novero D; Pelicci PG 《Blood》1989,74(7):2501-2507
Three cases of T-lymphoblastic lymphomas (T-LL) expressing the T cell antigen receptor gamma delta (TCR gamma delta) are reported. All of them were CD3+/beta F1-/TCR delta 1+. Moreover, neoplastic cells reacted with the delta TCS1 monoclonal antibody (MoAb) which binds to the non-disulfide-linked form of the TCR gamma delta, but not with the BB3 MoAb which recognizes the disulfide-linked form of the TCR gamma delta. All cases showed a stage II cortical phenotype, eg, TdT+/CD1+/CD3+/CD5+/CD7+; two of them coexpressed CD4/CD8, while the other was CD4+/CD8-. Two cases were positive for CALLA and CD25. Immunogenotypic analysis showed evidence of T beta and C gamma 2 gene rearrangements in all three cases and immunoglobulin (Ig) gene rearrangements in two cases. Two patients presented with an anterior mediastinal mass and the third with a solitary inguinal lymphadenopathy. We suggest that these cases of TCR gamma delta+ T-LL may be derived from the small population (approximately 0.5%) of CD3+ cortical thymocytes which, in the normal human thymus, express the delta TCS1-reactive, non-disulfide-linked form of the TCR gamma delta. 相似文献
505.
506.
ABSTRACTDermanyssus gallinae, also known as the poultry red mite (PRM), is a blood-feeding ectoparasite of poultry and sylvatic birds. This mite is endemic in many parts of the globe and poses a threat to the egg industry, while compromising the health and welfare of hens, both directly and as a vector of diseases. In addition, people attacked by D. gallinae may develop gamasoidosis. Despite the high prevalence in several European countries, epidemiological information on D. gallinae in Portugal is scarce. This study aimed to assess the prevalence and infestation levels in laying farms in Portugal and evaluate the perception and attitudes of producers regarding D. gallinae. A survey was performed between August 2016 – November 2017, which included 24 farms in the NUTS2 regions Centro and Norte. Mites were sampled with corrugated cardboard traps and the perception and attitudes of farmers regarding the PRM were evaluated with the European COREMI questionnaire prepared by WG 1 of the COST action FA1404. D. gallinae was detected in 95.8% of farms (95% CI: 79.8–99.3%). The average number of trapped mites among farms was 5200?±?16,522, with a median of 359 mites (interquartile range?=?46–3135). Results from the questionnaire show that insufficient monitoring, under-detection and late and suboptimal treatment may contribute to the maintenance of significant infestation levels. The present data highlight the need for adequate monitoring of D. gallinae, timely action and effective treatment in order to improve poultry productivity and ensure human and animal health and welfare.RESEARCH HIGHLIGHTS
A survey on the prevalence of D. gallinae in Portuguese layer farms is presented
The perceived importance of D. gallinae was assessed with a questionnaire
D. gallinae was detected in 95.8% of farms
The results emphasize the need for adequate monitoring and treatment optimization.