全文获取类型
收费全文 | 2115篇 |
免费 | 108篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 37篇 |
儿科学 | 63篇 |
妇产科学 | 9篇 |
基础医学 | 318篇 |
口腔科学 | 108篇 |
临床医学 | 144篇 |
内科学 | 525篇 |
皮肤病学 | 59篇 |
神经病学 | 165篇 |
特种医学 | 68篇 |
外科学 | 262篇 |
综合类 | 3篇 |
预防医学 | 62篇 |
眼科学 | 38篇 |
药学 | 171篇 |
中国医学 | 11篇 |
肿瘤学 | 191篇 |
出版年
2023年 | 17篇 |
2022年 | 29篇 |
2021年 | 68篇 |
2020年 | 43篇 |
2019年 | 34篇 |
2018年 | 52篇 |
2017年 | 41篇 |
2016年 | 46篇 |
2015年 | 40篇 |
2014年 | 60篇 |
2013年 | 66篇 |
2012年 | 113篇 |
2011年 | 150篇 |
2010年 | 81篇 |
2009年 | 58篇 |
2008年 | 114篇 |
2007年 | 129篇 |
2006年 | 126篇 |
2005年 | 116篇 |
2004年 | 112篇 |
2003年 | 98篇 |
2002年 | 110篇 |
2001年 | 37篇 |
2000年 | 35篇 |
1999年 | 28篇 |
1998年 | 23篇 |
1997年 | 12篇 |
1996年 | 16篇 |
1995年 | 13篇 |
1994年 | 15篇 |
1993年 | 12篇 |
1992年 | 18篇 |
1991年 | 26篇 |
1990年 | 27篇 |
1989年 | 26篇 |
1988年 | 12篇 |
1987年 | 23篇 |
1986年 | 21篇 |
1985年 | 27篇 |
1984年 | 19篇 |
1983年 | 12篇 |
1982年 | 11篇 |
1979年 | 11篇 |
1978年 | 8篇 |
1976年 | 7篇 |
1974年 | 8篇 |
1973年 | 13篇 |
1972年 | 8篇 |
1969年 | 8篇 |
1968年 | 10篇 |
排序方式: 共有2234条查询结果,搜索用时 468 毫秒
61.
62.
63.
64.
65.
Anthony Echo Leo R. Otake John R. Talley Thomas Satterwhite Jeffrey A. Norton Gordon K. Lee 《European journal of plastic surgery》2013,36(7):457-462
Complex thoraco-abdominal wall defects following tumor resection create a unique reconstructive challenge, which centers on anatomically re-establishing the thoracic and abdominal compartments to prevent visceral herniation. Autologous tissue may not be available or adequate to reconstruct these defects; therefore, the use of alternative options, such as non-autologous material, is often necessary. To our knowledge, very little has been described about the use of biologic mesh for the reconstruction of large thoracic defects. We present a review of the literature and present a novel approach to address a difficult defect with the use of cross-linked porcine dermal collagen (Permacol) to bridge a thoraco-abdominal defect while stabilizing the diaphragm. Level of Evidence: Level V, therapeutic study. 相似文献
66.
67.
Ryo Nishio Toshiro ShinkeHiromasa Otake Masayuki NakagawaTakumi Inoue Hirotoshi HarikiTsuyoshi Osue Yu TaniguchiMasamichi Iwasaki Noritoshi HiranumaAkihide Konishi Hiroto KinutaniMasaru Kuroda Ken-ichi Hirata 《Thrombosis research》2013
Background
The impact of paraoxonase-1 (PON1) activity on the response to clopidogrel may differ in patients treated with drug-eluting stents (DES) in association with CYP2C19 loss-of-function (LOF) polymorphisms.Methods
This study included 112 Japanese patients receiving clopidogrel (75 mg/day) and aspirin (100 mg/day) who underwent optical coherence tomography (OCT) examination 9 months after DES implantation. The CYP2C19 genotype was analyzed and LOF carriers (*1/*2, *1/*3, *2/*2, *3/*3, *2/*3) were identified. At the 9-month follow-up, platelet reactivity was determined by measuring the P2Y12 reactivity unit (PRU) using a VerifyNow P2Y12 assay, PON1 activity was evaluated and intra-stent thrombus was evaluated by OCT.Results
Of the 112 Japanese patients, 75 were LOF carriers (67.0%). The patients were divided into tertiles according to the PON1 activity (tertile 1; < 230 U/L, tertile 2; 230–283 U/L, tertile 3; > 283 U/L). In the VerifyNowP2Y12 analysis, tertile 1 had a higher PRU than tertiles 2 and 3 in LOF carriers, and there was no difference among tertiles in non-carriers. The highest incidence of intra-stent thrombus was observed in tertile 1 followed by tertiles 2 and 3 in LOF carriers, whereas there was no such difference in non-carriers. Multivariate analysis revealed that LOF carriers and PON1 activity tertile 1 were independent predictors of intra-stent thrombus in all patients. In LOF carriers, tertile 1 was the only independent predictor for intra-stent thrombus.Conclusion
Low PON1 activity is associated with a low response to clopidogrel and a high frequency of intra-stent thrombus only in LOF carriers. 相似文献68.
Satoshi Oki Mikihiro Inoue Kohei Otake Kohei Matsushita Yuhki Koike Keiichi Uchida Masato Kusunoki 《International journal of urology》2016,23(6):520-522
Bladder rupture in a fetus is a rare occurrence. We report the first neonatal case of laparoscopic repair for prenatally diagnosed bladder rupture. A male neonate, who had presented with megacystis, bilateral hydronephrosis and hydroureters since 27 weeks‐of‐gestation, was delivered by emergency cesarean section because of sudden collapse of the bladder with massive ascites at 37 weeks‐of‐gestation. The diagnosis of bladder rupture was made by retrograde urethrocystography. Laparoscopic repair was carried out subsequent to urethral catheterization. Intraoperatively, laceration from the left side of the bladder dome to the posterior wall was observed. This tear was successfully repaired using a two‐layer interrupted suture without any postoperative complications. Laparoscopic repair could be the treatment of choice for bladder rupture, because it has the advantage of closure of the perforated site more certainly than bladder decompression alone, and with better cosmesis than open repair. 相似文献
69.
Yoshiki Okita Toshimitsu Araki Keiichi Uchida Kohei Matsushita Mikio Kawamura Yuhki Koike Kohei Otake Mikihiro Inoue Yuji Toiyama Masaki Ohi Koji Tanaka Yasuhiro Inoue Yasuhiko Mohri Masato Kusunoki 《Pediatrics international》2016,58(7):625-628
Apart from primary pouchitis, patients with secondary pouchitis caused by surgical complications require surgical management. The use of abdomino‐anal salvage surgery to treat secondary pouchitis caused by surgical complications in pediatric patients with ulcerative colitis (UC) has not been reported in detail. A girl was diagnosed with UC at 8 years old. She underwent restorative proctocolectomy with ileal pouch–anal anastomosis (IPAA) at 9 years old. She presented at 12 years old because of chronic antibiotic‐refractory pouchitis. The fistula and stricture failed to improve despite multiple local salvage surgeries and ileostomy construction. At 15 years old, she underwent redo IPAA. The patient was well at 20 years old with no signs of pouchitis. Early treatment by abdomino‐anal salvage surgery might be indicated to improve quality of life in pediatric patients with secondary pouchitis caused by surgical complication unresponsive to defunctioning and local salvage surgery. 相似文献
70.
Toshinori Sakai Yuichiro Goda Fumitake Tezuka Mitsunobu Abe Kazuta Yamashita Yoichiro Takata Kosaku Higashino Akihiro Nagamachi Koichi Sairyo 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2016,26(3):259-262