全文获取类型
收费全文 | 17696篇 |
免费 | 778篇 |
国内免费 | 121篇 |
专业分类
耳鼻咽喉 | 250篇 |
儿科学 | 412篇 |
妇产科学 | 200篇 |
基础医学 | 2099篇 |
口腔科学 | 278篇 |
临床医学 | 979篇 |
内科学 | 4363篇 |
皮肤病学 | 675篇 |
神经病学 | 1356篇 |
特种医学 | 973篇 |
外科学 | 3147篇 |
综合类 | 96篇 |
一般理论 | 2篇 |
预防医学 | 363篇 |
眼科学 | 219篇 |
药学 | 1108篇 |
中国医学 | 42篇 |
肿瘤学 | 2033篇 |
出版年
2023年 | 84篇 |
2022年 | 162篇 |
2021年 | 341篇 |
2020年 | 219篇 |
2019年 | 235篇 |
2018年 | 293篇 |
2017年 | 288篇 |
2016年 | 349篇 |
2015年 | 358篇 |
2014年 | 508篇 |
2013年 | 609篇 |
2012年 | 873篇 |
2011年 | 988篇 |
2010年 | 644篇 |
2009年 | 579篇 |
2008年 | 978篇 |
2007年 | 1059篇 |
2006年 | 1042篇 |
2005年 | 1001篇 |
2004年 | 993篇 |
2003年 | 940篇 |
2002年 | 1011篇 |
2001年 | 348篇 |
2000年 | 355篇 |
1999年 | 399篇 |
1998年 | 282篇 |
1997年 | 230篇 |
1996年 | 250篇 |
1995年 | 215篇 |
1994年 | 185篇 |
1993年 | 153篇 |
1992年 | 276篇 |
1991年 | 247篇 |
1990年 | 233篇 |
1989年 | 217篇 |
1988年 | 186篇 |
1987年 | 178篇 |
1986年 | 179篇 |
1985年 | 120篇 |
1984年 | 123篇 |
1983年 | 91篇 |
1982年 | 67篇 |
1981年 | 65篇 |
1980年 | 63篇 |
1979年 | 64篇 |
1978年 | 45篇 |
1977年 | 39篇 |
1975年 | 39篇 |
1971年 | 40篇 |
1967年 | 43篇 |
排序方式: 共有10000条查询结果,搜索用时 9 毫秒
51.
Kazuhiko Sonoyama Haruaki Ninomiya Osamu Igawa Yasuhiro Kaetsu Yoshiyuki Furuse Toshihiro Hamada Junichiro Miake Peili Li Yasutaka Yamamoto Kazuhide Ogino Akio Yoshida Shin-ichi Taniguchi Yasutaka Kurata Satoshi Matsuoka Toshio Narahashi Goshi Shiota Yoshihisa Nozawa Hiroaki Matsubara Masatsugu Horiuchi Yasuaki Shirayoshi Ichiro Hisatome 《Hypertension research》2006,29(11):923-934
We examined the effects of angiotensin II (Ang II) on inward rectifier K+ currents (IK1) in rat atrial myocytes. [125I]Ang II-binding assays revealed the presence of both Ang II type 1 (AT1) and type 2 (AT2) receptors in atrial membrane preparations. Ang II inhibited IK1 in isolated atrial myocytes with an IC50 of 46 nmol/l. This inhibition was abolished by the AT, antagonist RNH6270 but not at all by the AT2 antagonist PD123319. Treatment of cells with pertussis toxin or a synthetic decapeptide corresponding to the carboxyl-terminus of Gialpha-3 abolished the inhibition by Ang II, indicating the role of a Gi-dependent signaling pathway. Accordingly, Ang II failed to inhibit IK1 in the presence of forskolin, dibutyryl-cAMP or protein kinase A catalytic subunits. In spite of the increased binding capacities for [125I]Ang II, Ang II failed to affect IKI in cells from spontaneously hypertensive rats (SHR). AT, immunoprecipitation from atrial extracts revealed decreased amounts of Gialpha-2 and Gialpha-3 proteins associated with this receptor in SHR as compared with controls. The reduced coupling of AT, with Gialpha. proteins may underlie the unresponsiveness of atrial IK1 to Ang II in SHR cells. 相似文献
52.
Osamu Kikuchi Hiroyuki Murai Koji Ikezoe Masakazu Kawajiri Yasumasa Ohyagi Emiko Isogai Jun-ichi Kira 《Clinical neurology》2004,44(4-5):299-302
A 58-year-old woman suffered from stiffness, swelling, rubor and muscle pain in the extremities one month after she climbed a mountain in Kyushu, an island in southern Japan. On admission, mild proximal weakness was present in the extremities. Her range of motion in the extremities was limited due to firm skin and subcutaneous stiffness which was similar to scleroderma. She showed peripheral blood eosinophilia and hypergammaglobulinemia as well as a high erythrocyte sedimentation rate. An IgM antibody against Borrelia afzelii was positive. MRI of the skeletal muscles demonstrated enhancing fascia around the biceps brachii muscle, and a biopsy specimen revealed perivascular infiltration of mononuclear cells within the hypertrophic fascia. Eosinophilic infiltration was absent. We treated the patient with prednisolone, doxycycline and amoxicillin, which alleviated the symptoms. This is the first report to show that Borrelia afzelii was involved in eosinophilic fasciitis. 相似文献
53.
54.
55.
Hideo Kanauchi Sadao Imamura Masahiro Takigawa Fukumi Furukawa 《The Journal of dermatology》1994,21(12):935-939
Kampo, a Japanese-Chinese traditional herbal medicine, has been used for the treatment of various diseases for about 3,000 years in China. Among herbal medicines, Sairei-to is well known for improving the symptoms of rheumatoid arthritis (RA) and other collagen diseases. However, its immunosuppressive effects on autoimmune cutaneous phenomena are not completely understood. We investigated the effects of Sairei-to on the development of lupus dermatoses in autoimmune-prone MRL/Mp-lpr/lpr (MRL/lpr) mice, an animal model which spontaneously develops skin lesions similar to those seen in human lupus erythematosus. Virgin female MRL/lpr mice at 1 month of age, which were treated orally with Sairei-to, had reduced amounts of IgG deposition at the dermoepidermal junction, titers of anti-DNA antibodies and rheumatoid factor, and lymphoproliferation. These results support the use of traditional herbal medicines in patients with human RA and systemic lupus erythematosus. 相似文献
56.
H Furukawa O Imventarza R Venkataramanan M Suzuki Y Zhu V S Warty J Fung S Todo T E Starzl 《Transplantation》1992,53(4):722-725
Mongrel or beagle dogs were submitted to bile duct ligation, or to extraenteric biliary diversion by means of choledochoureterostomy. The kinetics of intravenously administered FK506 was not changed from control status two weeks after bile duct ligation, but the bioavailability of orally administered FK506 was nearly quadrupled. Following oral administration, the absorption of FK506 was highly variable. The results indicate that in dogs FK506 is absorbed from the intestine just as efficiently in the absence of enteric bile and in presence of exogenous bile salt supplement when compared with its absorption in presence of normal bile drainage. These findings with FK506 are different from those with cyclosporine after biliary obstruction or diversion and will have important practical as well as experimental ramifications. 相似文献
57.
Katsumi Kimura Naotaka Fujita Yutaka Noda Go Kobayashi Kei Ito Jun Horaguchi Toshiki Sugawara Osamu Takasawa 《Digestive endoscopy》2004,16(1):54-57
Clinical diagnosis of chronic cholecystitis is made based on diffuse hyperechoic thickening of the gallbladder wall as shown by ultrasonographic examination. We herein report three cases of chronic cholecystitis showing localized hypoechoic thickening of the gallbladder wall that mimicked gallbladder cancer by ultrasonography. Histologically, hypertrophy of the muscularis propria was a common characteristic finding in these three patients. A smooth surface of the inner hypoechoic layer of the thickened wall was considered to be a reliable finding in the differential diagnosis between this type of chronic cholecystitis and gallbladder cancer. 相似文献
58.
Results of low- and high-dose-rate interstitial brachytherapy for T3 mobile tongue cancer. 总被引:2,自引:0,他引:2
Naoya Kakimoto Takehiro Inoue Toshihiko Inoue Shumei Murakami Souhei Furukawa Ken Yoshida Yasuo Yoshioka Hideya Yamazaki Eiichi Tanaka Kimishige Shimizutani 《Radiotherapy and oncology》2003,68(2):123-128
PURPOSE: To evaluate the treatment results of low-dose-rate (LDR) and high-dose-rate (HDR) interstitial brachytherapy (ISBT) for T3 mobile tongue cancer. MATERIAL AND METHODS: Between 1974 and 1992, 61 patients with T3 mobile tongue cancer were treated with LDR ISBT using (192)Ir hairpins with or without single pins. In addition, between 1991 and 1999, 14 patients were treated with HDR ISBT. For nine patients treated with ISBT alone, the total dose was 59-94 Gy (median 72 Gy) within one week in LDR ISBT and 60 Gy/10 fractions/5 days in HDR ISBT. For 66 patients treated with a combination therapy of external beam radiotherapy (EBRT) and ISBT, the total dose was 12.5-60 Gy (median 30 Gy) of EBRT and 50-112 Gy (median 68 Gy) within 1 week in LDR ISBT or 32-60 Gy (median 48 Gy)/8-10 fractions/5-7 days in HDR ISBT. RESULTS: The 2- and 3-year local control rates of all patients were both 68%. The 2- and 3-year local control rates of patients treated with LDR ISBT were both 67%, and those with HDR ISBT were both 71%. The local control rate of patients treated with HDR ISBT was similar to those with LDR ISBT. CONCLUSIONS: ISBT for T3 mobile tongue cancer is effective and acceptable. The treatment result of HDR ISBT is almost similar to that of LDR ISBT for T3 mobile tongue cancer. 相似文献
59.
60.
Jira Chindasombatjaroen Naoya Kakimoto Hironori Akiyama Kazuko Kubo Shumei Murakami Souhei Furukawa Mitsunobu Kishino 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2007,104(6):e52-e57
The calcifying cystic odontogenic tumor is a rare benign odontogenic lesion. This report documents a case of this lesion associated with odontoma arising from the anterior maxilla in a 14-year-old boy. The diagnosis was confirmed based on computerized tomography findings, which clearly depicted the internal structures obscured in conventional images. 相似文献