全文获取类型
收费全文 | 17035篇 |
免费 | 988篇 |
国内免费 | 76篇 |
专业分类
耳鼻咽喉 | 261篇 |
儿科学 | 374篇 |
妇产科学 | 282篇 |
基础医学 | 2487篇 |
口腔科学 | 1749篇 |
临床医学 | 1359篇 |
内科学 | 3505篇 |
皮肤病学 | 410篇 |
神经病学 | 1243篇 |
特种医学 | 464篇 |
外科学 | 1811篇 |
综合类 | 82篇 |
一般理论 | 4篇 |
预防医学 | 1925篇 |
眼科学 | 195篇 |
药学 | 1255篇 |
中国医学 | 174篇 |
肿瘤学 | 519篇 |
出版年
2023年 | 149篇 |
2022年 | 425篇 |
2021年 | 637篇 |
2020年 | 434篇 |
2019年 | 548篇 |
2018年 | 686篇 |
2017年 | 534篇 |
2016年 | 523篇 |
2015年 | 690篇 |
2014年 | 832篇 |
2013年 | 947篇 |
2012年 | 1419篇 |
2011年 | 1576篇 |
2010年 | 845篇 |
2009年 | 641篇 |
2008年 | 1009篇 |
2007年 | 1031篇 |
2006年 | 818篇 |
2005年 | 708篇 |
2004年 | 587篇 |
2003年 | 502篇 |
2002年 | 412篇 |
2001年 | 271篇 |
2000年 | 253篇 |
1999年 | 196篇 |
1998年 | 103篇 |
1997年 | 95篇 |
1996年 | 84篇 |
1995年 | 70篇 |
1994年 | 71篇 |
1993年 | 54篇 |
1992年 | 88篇 |
1991年 | 93篇 |
1990年 | 61篇 |
1989年 | 75篇 |
1988年 | 64篇 |
1987年 | 44篇 |
1986年 | 53篇 |
1985年 | 50篇 |
1984年 | 31篇 |
1983年 | 43篇 |
1981年 | 24篇 |
1980年 | 33篇 |
1979年 | 34篇 |
1978年 | 17篇 |
1977年 | 24篇 |
1976年 | 18篇 |
1973年 | 20篇 |
1970年 | 16篇 |
1968年 | 32篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Salamoni SD Costa da Costa J Palma MS Konno K Nihei K Tavares AA de Abreu DS Venturin GT de Borba Cunha F de Oliveira RM Breda RV 《Brain research》2005,1048(1-2):170-176
The Joro spider toxin (JSTX-3), derived from Nephila clavata, has been found to block glutamate excitatory activity. Epilepsy has been studied in vitro, mostly on rat hippocampus, through brain slices techniques. The aim of this study is to verify the effect of the JSTX-3 on the epileptiform activity induced by magnesium-free medium in rat CA1 hippocampal neurons. Experiments were performed on hippocampus slices of control and pilocarpine-treated Wistar rats, prepared and maintained in vitro. Epileptiform activity was induced through omission of magnesium from the artificial cerebrospinal fluid (0-Mg2+ ACSF) superfusate and iontophoretic application of N-methyl-D-aspartate (NMDA). Intracellular recordings were obtained from CA1 pyramidal neurons both of control and epileptic rats. Passive membrane properties were analyzed before and after perfusion with the 0-Mg2+ ACSF and the application of toxin JSTX-3. During the ictal-like activity, the toxin JSTX-3 was applied by pressure ejection, abolishing this activity. This effect was completely reversed during the washout period when the slices were formerly perfused with artificial cerebrospinal fluid (ACSF) and again with 0-Mg2+ ACSF. Our results suggest that the toxin JSTX-3 is a potent blocker of induced epileptiform activity. 相似文献
992.
Magina S Santos J Coroas A Oliveira JG Serrão P Soares-Da-Silva P Resende C Pestana M 《The British journal of dermatology》2005,152(4):773-776
BACKGROUND: Hypertension is one of the main side-effects of long-term therapy with ciclosporin. However, the influence of salt intake on the 24-h mean blood pressure of patients with psoriasis treated with ciclosporin is not known. OBJECTIVES: To evaluate, in patients with psoriasis, the sodium sensitivity of the ciclosporin-induced rise in blood pressure. METHODS: The 24-h ambulatory blood pressure was evaluated in 13 patients with psoriasis (age range 20-57 years) in two phases, before (phase I) and after the completion of 4 months of therapy with ciclosporin 3 mg kg(-1) daily (phase II). In both phases, the patients were studied in conditions of low sodium (LS) intake followed by a high sodium (HS) diet. RESULTS: Twenty-four-hour mean +/- SD blood pressure during LS and HS intake was, respectively, 86.3 +/- 1.6 mmHg and 85.5 +/- 1.8 mmHg during phase I, and 88.5 +/- 1.5 mmHg and 91.8 +/- 2.2 mmHg (P < 0.001 vs. phase I, HS; P < 0.05 vs. phase II, LS) during phase II. The median (interquartile range) sodium sensitivity index was greater during phase II than during phase I: - 0.0028 (- 0.0071 to 0.0009) vs. 0.0065 (- 0.0055 to 0.0258) (P < 0.02). The plasma levels and the daily urinary excretion of noradrenaline did not differ between phases I and II. CONCLUSIONS: The ciclosporin-induced rise in blood pressure is sodium sensitive. It is also suggested that sympathetic activation is not involved in the pathogenesis of ciclosporin-induced rise in blood pressure. 相似文献
993.
The uniqueness of the clinical-dermatologic elements of leprosy recommends that control programs worldwide should diagnose the disease based on the so-called main clinical signs: cutaneous-neurological lesions with sensitivity-motor alterations without obligatory bacteriologic or histopathologic examination. The recognition of initial signs and symptoms of Hansen disease sometimes presents difficulties for its diagnosis, especially considering the relevance of an early diagnosis and the present guidelines for performance of decentralized treatment of the patient in the basic health-care network. The clinical cases illustrating this article were selected because of the degree of difficulty found in the confirmation of their diagnoses that required a histopathologic and/or bacteriologic examination. 相似文献
994.
Bain MD Till J Jones MG Besley GT Lee P Oliveira D Chalmers RA 《Journal of inherited metabolic disease》2005,28(6):1179-1180
Summary A 36-year follow-up on the original patient described with methylmalonic aciduria has shown that she has methylmalonyl-CoA
apomutase deficiency. The main clinical problem associated with her methylmalonic aciduria is progressive renal impairment
requiring commencement of haemodialysis at 42 years of age. 相似文献
995.
996.
997.
998.
999.
1000.
The term neurofibromatosis (NF) is used for a group of genetic disorders that primarily affect the cell growth of neural tissues. Neurofibromatosis type 1 (NF1), also known as von Recklinghausen's disease, is the most common type of NF and accounts for about 90% of all cases. It is one of the most frequent human genetic diseases, with a prevalence of one case in 3,000 births. The expressivity of NF1 is extremely variable, with manifestations ranging from mild lesions to several complications and functional impairment. Oral manifestations can be found in almost 72% of NF1 patients. A case of a NF1 patient with a gingival neurofibroma in the attached gingiva of the lingual aspect of the lower central incisors is presented. The lesion was nodular, with sessile base, non-ulcerated, non-painful, with normal colour and measured 1 cm in diameter. An excisional biopsy of the oral lesion was performed. Histopathological and immunohistochemical analysis confirmed the clinical hypothesis of neurofibroma. Because NF1 is one of the most common genetic diseases and oral manifestations are very common, dentists should be aware of the characteristics of this disease. 相似文献