全文获取类型
收费全文 | 11396篇 |
免费 | 671篇 |
国内免费 | 127篇 |
专业分类
耳鼻咽喉 | 198篇 |
儿科学 | 74篇 |
妇产科学 | 135篇 |
基础医学 | 2086篇 |
口腔科学 | 324篇 |
临床医学 | 943篇 |
内科学 | 1850篇 |
皮肤病学 | 453篇 |
神经病学 | 1044篇 |
特种医学 | 639篇 |
外科学 | 1566篇 |
综合类 | 36篇 |
一般理论 | 2篇 |
预防医学 | 463篇 |
眼科学 | 278篇 |
药学 | 1236篇 |
中国医学 | 151篇 |
肿瘤学 | 716篇 |
出版年
2024年 | 7篇 |
2023年 | 77篇 |
2022年 | 293篇 |
2021年 | 475篇 |
2020年 | 200篇 |
2019年 | 304篇 |
2018年 | 358篇 |
2017年 | 276篇 |
2016年 | 389篇 |
2015年 | 502篇 |
2014年 | 649篇 |
2013年 | 729篇 |
2012年 | 1043篇 |
2011年 | 978篇 |
2010年 | 621篇 |
2009年 | 526篇 |
2008年 | 740篇 |
2007年 | 729篇 |
2006年 | 642篇 |
2005年 | 556篇 |
2004年 | 446篇 |
2003年 | 384篇 |
2002年 | 314篇 |
2001年 | 218篇 |
2000年 | 188篇 |
1999年 | 129篇 |
1998年 | 59篇 |
1997年 | 45篇 |
1996年 | 31篇 |
1995年 | 27篇 |
1994年 | 20篇 |
1993年 | 17篇 |
1992年 | 34篇 |
1991年 | 31篇 |
1990年 | 31篇 |
1989年 | 22篇 |
1988年 | 16篇 |
1987年 | 16篇 |
1986年 | 8篇 |
1985年 | 8篇 |
1984年 | 10篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 4篇 |
1979年 | 7篇 |
1978年 | 5篇 |
1977年 | 5篇 |
1976年 | 5篇 |
1969年 | 2篇 |
1968年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
961.
Analytical Performance Evaluation of Infopia Element™ Auto‐coding Blood Glucose Monitoring System for Self‐Monitoring of Blood Glucose 下载免费PDF全文
962.
Incidence and patterns of cardiomyopathy in carbon monoxide-poisoned patients with myocardial injury
Yong Sung Cha Sung Oh Hwang Jang Young Kim Yun Kwon Kim Eun Hee Choi 《Clinical toxicology (Philadelphia, Pa.)》2016,54(6):481-487
Objectives: Sustained myocardial injury is a significant predictor of mortality in carbon monoxide (CO) poisoning. There are few reports in the literature regarding the presence of CO-induced cardiomyopathy from early stages in the emergency department (ED). We prospectively investigated the early incidence of CO-induced cardiomyopathy and its patterns in patients with cardiomyopathy. Materials and methods: During a 10-month period, transthoracic echocardiography (TTE) was performed in 43 consecutive patients with CO poisoning and myocardial injury, which was defined as elevated high-sensitive troponin I within 24?h after ED arrival. Measurements of left ventricular ejection fraction and wall motion abnormalities were performed to evaluate cardiac function. If a patient had CO-induced cardiomyopathy, we measured cardiac function at the time of patient admission, day 1, day 2, and once within seven days of hospitalization. Results: The incidence of cardiomyopathy was as high as 74.4% (32 of 43 patients) in CO-poisoned patients with myocardial injury based on initial ED results. Echocardiographic patterns included non-cardiomyopathy (25.6%), global dysfunction (51.2%), and Takotsubo-like cardiomyopathy (23.2%). Patients in the global dysfunction group had significantly more normalized cardiac dysfunction within 72?h than did those in the Takotsubo-like cardiomyopathy group (81.8% vs. 22.2%, p?=?0.001). Discussion and conclusion: Patients with CO poisoning and myocardial injury experienced cardiomyopathy, including reversible global dysfunction and a Takotsubo-like pattern. Investigation of cardiomyopathy needs to be considered in patients with CO poisoning and myocardial injury. 相似文献
963.
964.
Novel complex class 1 integron bearing an ISCR1 element in an Escherichia coli isolate carrying the blaCTX-M-14 gene 总被引:1,自引:0,他引:1 下载免费PDF全文
This work identifies an ISCR1-related bla(CTX-M-14) gene, which has never been reported before, from a clinical isolate of Escherichia coli. The bla(CTX-M-14) gene was preceded by an ISCR1 element that was followed by a class 1 integron containing three different insert gene cassettes, i.e., dfrA12, orfF, and aadA2. 相似文献
965.
Satoi S Matsui Y Kitade H Yanagimoto H Toyokawa H Yamamoto H Hirooka S Kwon AH Kamiyama Y 《HPB : the official journal of the International Hepato Pancreato Biliary Association》2008,10(4):289-295
Background/Aims. Our policy for the surgical treatment of hepatocellular carcinoma (HCC) has been to minimize the extent of liver resection using a microwave tissue coagulator (MTC) and to not perform Pringle''s maneuver for the prevention of ischemic injury to the liver routinely. We verify the safety of liver resection using MTC in HCC patients with poor liver functional reserve, and clarify the long-term outcome of HCC patients who underwent curative resection using MTC. Methodology. One hundred sixty-eight patients who underwent curative resection using MTC between 1992 and 2001 were divided into two groups according each patient''s score in the Indocyanin Green Retension 15 Test (ICG-R15 test). The high (ICG-R15 values>20) and low ICG-R15 groups (ICG-R15 values<20) included 100 and 68 HCC patients, respectively. Clinical characteristics of each group were evaluated, and operative mortality and morbidity, as well as overall and disease-free survival rates, were compared between the two groups to determine risk factors for overall and disease-free survival. Results. Although there were significant differences in liver function-related parameters between the low and high ICG-R15 groups, no differences in surgical or tumor factors were found. No patients in this study developed post-operative liver failure, and there was no significant difference in morbidity between the low and high ICG-R15 groups. The overall survival rate of the low ICG-R15 group was significantly longer than the high ICG-R15 group (p=0.0003). Cox''s multivariate analysis showed that an ICG-R15 value less than 20 was the only significant independent factor for overall survival. Disease-free survival rates in the low ICG-R15 group were significantly longer than in the high ICG-R15 group (p=0.0007). Multivariate analysis showed that serum albumin level and number of tumors were significant independent factors for disease-free survival. Conclusion. The long-term outcome of HCC patients with low ICG-R15 following curative resection using MTC was acceptable. This procedure was safe even for patients with high ICG-R15. 相似文献
966.
967.
Ji-Eun Song Dong-Won Yang Hyun-Jin Seo Sam-Yeol Ha Kwang-Yeol Park Oh-Sang Kwon Young Chul Youn 《Journal of clinical neuroscience》2010,17(10):1341-1343
We report a 59-year-old woman who presented to our facility with conduction aphasia as an initial symptom which, within 3 months, was followed by generalized myoclonus and global aphasia. She had difficulty repeating words during the Korean–Western Aphasia Battery test. Diffusion-weighted MRI demonstrated ribbon-like hyperintensities in the bilateral temporal, parietal and occipital cerebral cortex. An electroencephalogram showed periodic discharges over the bilateral hemispheres, while single photo emission CT revealed diminished perfusion. After a positive finding of the 14-3-3 protein in her cerebrospinal fluid, she was diagnosed as having probable sporadic Creutzfeldt–Jakob disease. 相似文献
968.
Xian Ji Jin Joon Mee Kim Hyung Kil Kim Lucia Kim Suk Jin Choi In Suh Park Jee Young Han Young Chae Chu Ju Young Song Kye Sook Kwon Eun Joo Kim 《World journal of gastroenterology : WJG》2010,16(20):2496-2503
AIM: To compare the histopathologic features of intestinal tuberculosis (ITB) and Crohn’s disease (CD) and to identify whether polymerase chain reaction for Mycobacterium tuberculosis (TB-PCR) would be helpful for differential diagnosis between ITB and CD.METHODS: We selected 97 patients with established diagnoses (55 cases of ITB and 42 cases of CD) who underwent colonoscopic biopsies. Microscopic features of ITB and CD were reviewed, and eight pathologic parameters were evaluated. Nine cases of acid fast bacilli culture-positive specimens and 10 normal colonic tissue specimens were evaluated as the positive and negative control of the TB-PCR test, respectively. PCR assays were done using two commercial kits: kit detected IS6110 and MPB64, and kit detected IS6110 only; a manual in-house PCR method was also performed on formalin-fixed, paraffin-embedded colonoscopic biopsy specimens.RESULTS: Statistically significant differences were noted between ITB and CD with regard histopathologic criteria: size of granulomas (P = 0.000), giant cells (P = 0.015), caseation necrosis (P = 0.003), confluent granulomas (P = 0.001), discrete granulomas (P = 0.000), and granulomas with lymphoid cuffs (P = 0.037). However, 29 cases (52.7%) of ITB showed less than five kinds of pathologic parameters, resulting in confusion with CD. The sensitivities and specificities of the TB-PCR test by kit , kit , and the in-house PCR method were 88.9% and 100%, 88.9% and 100%, and 66.7% and 100% in positive and negative controls, respectively. The PCR test done on endoscopic biopsy specimens of ITB and CD were significantly different with kit (P = 0.000) and kit (P = 0.000). The sensitivities and specificities of TB-PCR were 45.5% and 88.1%, 36.4% and 100%, and 5.8% and 100%, for kit and kit and in-house PCR method on endoscopic biopsy specimens. Among the 29 cases of histopathologically confusing CD, 10 cases assayed using kit and 6 cases assayed using kit were TB-PCR positive. A combination of histologic findings and TB-PCR testing led to an increase of diagnostic sensitivity and the increase (from 47.3% to 58.2) was statistically significant with kit (P = 0.000).CONCLUSION: The TB-PCR test combined with histopathologic factors appears to be a helpful technique in formulating the differential diagnosis of ITB and CD in endoscopic biopsy samples. 相似文献
969.
970.
Won Ki Lee Seok‐Soo Byun Hyeon Hoe Kim Koon Ho Rha Tae‐Kon Hwang Gyung Tak Sung Wan Lee Jae Sung Lim Young Beom Jeong Tae Gyun Kwon 《International journal of urology》2010,17(11):898-904
Objectives: To analyze the characteristics and the prognostic significance of chromophobe renal cell carcinomas (chRCC). Methods: Data about 2981 patients with non‐metastatic renal cell carcinomas (RCC) at the time of surgery were retrospectively collected from 26 institutions between 1998 and 2008. All patients had undergone partial or radical nephrectomies. Of the 2981 patients, 2602 patients with conventional RCC (cRCC) and 148 with chRCC were studied. Clinical and pathological parameters were determined in all patients. Recurrence‐free survival (RFS) and cancer‐specific survival (CSS) were assessed. Results: Patients with chRCC differed significantly from those with cRCC on the following parameters: younger age (P = 0.026), greater female ratio (P < 0.001), and larger tumor diameter (P < 0.001). Both groups were alike with respect to body mass index (P = 0.943), Eastern Cooperative Oncology Group performance status (P = 0.163), T stage (P = 0.375), and Fuhrman's grade (P = 0.134). The 5‐year RFS rates in patients with chRCC and cRCC were 82.7% and 83.3%, respectively (P = 0.762). The 5‐year CSS rates in patients with chRCC and cRCC were 88.8% and 92.2%, respectively (P = 0.980). Both groups showed equivalent oncological outcomes in terms of RFS and CSS for cases stratified by T stage and Fuhrman's grade. In multivariate analysis, the histological subtype was not retained as an independent prognostic variable (RFS: P = 0.893; CSS: P = 0.729). Conclusions: Despite being significantly different from cRCC in terms of several clinical and pathological parameters, chRCC shows equivalent oncological outcomes. 相似文献