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991.
Outcome of renal transplantation in patients over the age of 60: a case-control study 总被引:2,自引:1,他引:1
Nyberg G.; Nilsson B.; Norden G.; Karlberg I. 《Nephrology, dialysis, transplantation》1995,10(1):91-94
The outcome of kidney transplantation in 70 consecutive patientsaged 60 years or more was compared to that of matched contemporarycontrols aged 1854 years. Although the elderly patientswere a positive selection from a much larger population in dialysistheir first-year mortality was significantly increased (8 versusone of the controls, P = 0.016). Morbidity in bronchopneumoniawas also increased (11 versus 2, P = 0.009). In the group ofelderly patients six grafts were lost due to the death of thepatient. Neither the rate of irreversible rejection nor theneed for extra antirejection therapy differed between the groups.The increased mortality and morbidity suggest that the selectionhad not been too restricted. Thus kidney transplantation shouldonly be offered to a minority of elderly uraemic patients. 相似文献
992.
This is a report of a nonrandomized comparison of treatment results of 139 patients with stage IB, IIA and proximal IIB carcinoma
of the uterine cervix treated by radiation alone and 113 treated with a combination of radiation and surgery. The five-year
tumor free acturial survival for the patients with stage IB either with irradiation alone (RT) or combined with surgery (RS)
was approximately 87%. For stage II the tumor free actuarial five-year survival 79% with patients of RS, and 76% with RT.
In the 113 patients treated with RS there were 18 (16%). In the 139 patients treated by RT there were 18 (13%) recurrences
of pelvic, 4 local recurrences, 11 combined with parametrial, and free parametrial recurrences. There was no significant difference
in the survival and recurrence rate of the patients treated with either method. Major complications were comparable in both
groups (RT approximately 25% and RS approximately 10%), but 2/3 of those complications recovered without sequelae. The most
frequent minor complication in the patients treated with RT was rectosigmoiditis. 相似文献
993.
F. Chézalviel-Guilbert J. Weissenburger JM Davy C. Guhennec JM Poirier and G. Cheymol 《Fundamental & clinical pharmacology》1995,9(3):240-247
Summary— The proarrhythmic effects of 3-hydroxy-hydroquinidine (3-OH-HQ) and quinidine were compared in a canine model of QT-dependent ventricular arrhythmias. Eight hypokalemic ([K+] ≤ 3.2 mmol/l) dogs with AV block (around 45 bpm) were given either drug in a randomized order at 2-day intervals. Each drug was given as two 1 hour doses, with a bolus (low dose: 5 mg/kg or high dose: 10 mg/kg) plus infusion (25 or 50 μg/kg/min) protocol. Propranolol infusion was combined with a third hour of the high dose infusion. Electrophysiologic measurements were performed at baseline and 30 minutes after the beginning of each dose and propranolol infusion, and proarrhythmic events were recorded 30 minutes before and during the experiment. Neither drugs altered the ventricular cycle length. Quinidine and 3-OH-HQ prolonged the QT interval similarly and significantly when paced at 60 bpm after the low dose (+ 39 ± 18 and + 28 ± 22 msec, respectively) and after the high dose (+ 51 ± 29 and + 50 ± 22 msec). Quinidine was more arrhythmogenic than 3-OH-HQ: 7/8 dogs (p ≤ 0.05) developed ventricular arrhythmias (isolated, repetitive ventricular beats, or polymorphic ventricular tachycardias) during quinidine infusion (low dose: 4 dogs) compared to 3/8 dogs (NS) during 3-OH-HQ infusion (low dose: 1 dog). Addition of propranolol-induced bradycardia (around 30 bpm) caused torsades de pointes (wave burst arrhythmias) or polymorphic ventricular tachycardias after both drugs (in 3 dogs after quinidine and in 2 dogs after 3-OH-HQ). Thus 3-OH-HQ was slightly less arrhythmogenic than quinidine in this model of torsades de pointes, but the addition of an extra favouring factor (bradycardia) reduced that difference. 相似文献
994.
Cerebrospinal fluid shunts: flow measurements with MR imaging 总被引:1,自引:0,他引:1
The authors describe a technique for determination of shunt patency by quantifying cerebrospinal fluid shunt flow rates with magnetic resonance (MR) imaging. This method uses a modified clinical sequence that is both sensitive to slow flow perpendicular to the imaging plane and capable of achieving oblique angles with a 4-cm field of view. Velocity-dependent phase images were used to quantify flow rates within the shunt. A preliminary study was performed in seven patients with hydrocephalus and cerebrospinal fluid shunts. Two patients were found to have zero flow in the shunt, while the remaining five had flow rates ranging from 4 to 19 mL/h. Results showed that the measurement of flow rates within the shunt lumen with MR imaging is clinically feasible. 相似文献
995.
A dry cough, fever, generalized maculopapular rash, and myositis developed in a 67-year-old woman; she also had markedly abnormal liver function test results. Serologic tests proved that she had an infection of recent onset with Borrelia burgdorferi, the agent that causes Lyme disease. During a two-month course of illness, her condition remained refractory to treatment with antibiotics, salicylates, and steroids. Ultimately, fatal adult respiratory distress syndrome developed; this was believed to be secondary to Lyme disease. 相似文献
996.
Percutaneous cholecystolithotomy: preliminary experience 总被引:4,自引:0,他引:4
Percutaneous removal of gallstones was employed as the definitive form of therapy in three patients with acute cholecystitis. Percutaneous cholecystolithotomy may be an alternative form of therapy for selected patients with gallbladder calculi. 相似文献
997.
Cerebrovascular disease in childhood 总被引:1,自引:0,他引:1
998.
M Haimart A Pradalier JM Launay C Dreux J Dry 《Cephalalgia : an international journal of headache》1987,7(1):39-42
Whole blood and plasma histamine levels were measured in 27 non-medicated patients with common migraine. In nine cases blood was drawn 1-2 h after the onset of a migraine attack. The whole blood histamine levels of migraineurs and controls did not differ significantly. In contrast, histamine levels were significantly increased in plasma from patients both during and between migraine attacks, as compared with controls (p less than 0.001). Finally, plasma taken from migraine patients induced a significantly greater release of histamine from control whole blood than did plasma taken from control subjects (p less than 0.01). 相似文献
999.
1000.