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51.
Out of 280 immunotherapy (IT)-treated patients in our allergy clinic, 37 (13%) developed systemic adverse reactions. Parietaria judaica (Pj) extract, a highly allergenic pollen in northern Israel, was part of the IT regimen in 46% of treated patients who developed systemic adverse reactions. Twenty-six (70%) of systemic adverse reactions occurred during the buildup phase, whereas 11 (30%) occurred in the maintenance phase of treatment. Mild systemic reactions developed in 15/37 (40%), moderate in 20/37 (54%), and severe in 2/37 (5%) of patients. In 22/37 (59% of our IT-treated patients, adverse reactions developed within 30 min after injection. Among these were the two patients with severe systemic reactions. In 19%, moderate adverse reactions appeared at 30-60 min; in 22%, mild to moderate reactions appeared after 1-2 h. Our study concludes that severe systemic reactions to IT usually appear within 30 min after injection. In Israel, IT with highly allergenic pollens such as Pj frequently causes systemic reactions, even during the maintenance phase of treatment. In such cases, the reduction of IT dosage should be more than 50% during the pollen season, and a waiting period of 1 h should also be considered. 相似文献
52.
氯喹对烟雾吸入伤大鼠肺细胞膜ATP酶活性和丙二醛含量的影响 总被引:1,自引:0,他引:1
目的:探讨氯喹对烟雾吸入伤大鼠肺细胞膜ATP酶活性及丙二醛含量的影响,方法:80只Wistar大鼠随机分成正常对照组,烟雾吸入伤1,3,6,12和24h组以及氯喹治疗6h和12h组,分别于各时相点活杀动物,取肺制备膜制剂,用生化比色法测定膜上Na^+,K^+-ATP酶Mg^2+-ATP酶和Ca^2+-ATP酶活性,用比色法测定膜上丙醛含量,并用定磷法测定膜总磷脂含量,结果:烟雾吸入伤后,肺细胞膜3 相似文献
53.
Use and effectiveness of dapagliflozin in routine clinical practice: An Italian multicentre retrospective study 下载免费PDF全文
Gian Paolo Fadini MD Giancarlo Zatti MD Ileana Baldi PhD Daniele Bottigliengo Agostino Consoli Andrea Giaccari MD Giorgio Sesti Angelo Avogaro MD for the DARWIN‐TD network 《Diabetes, obesity & metabolism》2018,20(7):1781-1786
In randomized controlled trials (RCTs), sodium‐glucose co‐transporter‐2 (SGLT2) inhibitors have been shown to confer glycaemic and extra‐glycaemic benefits. The DARWIN‐T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes) study was a multicentre retrospective study designed to evaluate the baseline characteristics of patients receiving dapagliflozin vs those receiving selected comparators (dipeptidyl peptidase‐4 inhibitors, gliclazide, or glucagon‐like peptide‐1 receptor agonists), and drug effectiveness in routine clinical practice. From a population of 281 217, the analysis included 17 285 patients initiating dapagliflozin or comparator glucose‐lowering medications (GLMs), 6751 of whom had a follow‐up examination. At baseline, participants starting dapagliflozin were younger, had a longer disease duration, higher glycated haemoglobin (HbA1c) concentration, and a more complex history of previous GLM use, but the clinical profile of patients receiving dapagliflozin changed during the study period. Dapagliflozin reduced HbA1c by 0.7%, body weight by 2.7 kg, and systolic blood pressure by 3.0 mm Hg. Effects of comparator GLMs were also within the expected range, based on RCTs. This real‐world study shows an initial channelling of dapagliflozin to difficult‐to‐treat patients. Nonetheless, dapagliflozin provided significant benefits with regard to glucose control, body weight and blood pressure that were in line with findings from RCTs. 相似文献
54.
Natasha L Tilston Ken TD Eames Daniela Paolotti Toby Ealden W John Edmunds 《BMC public health》2010,10(1):650
Background
Internet-based surveillance systems to monitor influenza-like illness (ILI) have advantages over traditional (physician-based) reporting systems, as they can potentially monitor a wider range of cases (i.e. including those that do not seek care). However, the requirement for participants to have internet access and to actively participate calls into question the representativeness of the data. Such systems have been in place in a number of European countries over the last few years, and in July 2009 this was extended to the UK. Here we present results of this survey with the aim of assessing the reliability of the data, and to evaluate methods to correct for possible biases. 相似文献55.
G D Kersley OBE TD DL MD DSC FRCP 《Medicine, conflict, and survival》2013,29(2):109-114
Any nuclear war would be horrific and our main aim should be universal abolition of nuclear weapons. Civil defence, with its medical attributes, could certainly increase the survival rate should a disaster occur. The effect of the explosion of a nuclear warhead is outlined, together with what could be done to reduce casualties. Nuclear winter is discussed and it is suggested that the results of computerization of doubtful surmises have been treated too much as proven facts. The possibility of its occurrence should not deter emergency planning. Civil defence can save lives, and the fact that medicine as we know it would cease to exist in an all‐out nuclear war does not excuse us from doing what we can to increase the survival rate, if the worst should happen. Action should therefore be taken now to plan decentralization of resources and to instruct the public in protection, first aid and self‐sufficiency. 相似文献
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Hemoglobin A1c (HbA1c) changes over time among adolescent and young adult participants in the T1D exchange clinic registry 下载免费PDF全文
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本文初步研究了诺氟沙星缓释片的处方组成。并对不同处方进行了体外溶出试验,实验结果表明:本品的体外释药可维持12h以上且体外溶出符合一级动力学过程。 相似文献
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