全文获取类型
收费全文 | 3242篇 |
免费 | 180篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 67篇 |
儿科学 | 228篇 |
妇产科学 | 46篇 |
基础医学 | 380篇 |
口腔科学 | 54篇 |
临床医学 | 253篇 |
内科学 | 588篇 |
皮肤病学 | 58篇 |
神经病学 | 275篇 |
特种医学 | 70篇 |
外科学 | 514篇 |
综合类 | 70篇 |
一般理论 | 3篇 |
预防医学 | 178篇 |
眼科学 | 132篇 |
药学 | 253篇 |
中国医学 | 16篇 |
肿瘤学 | 254篇 |
出版年
2023年 | 23篇 |
2022年 | 58篇 |
2021年 | 141篇 |
2020年 | 80篇 |
2019年 | 95篇 |
2018年 | 132篇 |
2017年 | 86篇 |
2016年 | 122篇 |
2015年 | 107篇 |
2014年 | 150篇 |
2013年 | 175篇 |
2012年 | 262篇 |
2011年 | 236篇 |
2010年 | 140篇 |
2009年 | 133篇 |
2008年 | 202篇 |
2007年 | 211篇 |
2006年 | 175篇 |
2005年 | 146篇 |
2004年 | 134篇 |
2003年 | 106篇 |
2002年 | 95篇 |
2001年 | 48篇 |
2000年 | 47篇 |
1999年 | 34篇 |
1998年 | 17篇 |
1997年 | 19篇 |
1996年 | 17篇 |
1995年 | 9篇 |
1993年 | 5篇 |
1992年 | 21篇 |
1991年 | 17篇 |
1990年 | 14篇 |
1989年 | 20篇 |
1988年 | 17篇 |
1987年 | 15篇 |
1986年 | 6篇 |
1985年 | 12篇 |
1984年 | 16篇 |
1983年 | 8篇 |
1981年 | 4篇 |
1980年 | 7篇 |
1979年 | 13篇 |
1978年 | 6篇 |
1976年 | 12篇 |
1975年 | 5篇 |
1974年 | 10篇 |
1973年 | 3篇 |
1972年 | 7篇 |
1968年 | 5篇 |
排序方式: 共有3439条查询结果,搜索用时 265 毫秒
41.
To observe the effects of simvastatin on nuclear factor kappaB (NF-kB)-DNA binding activity and on the expression of monocyte chemoattractant protein-1 (MCP-1) in atherosclerotic plaque in rabbits and to explore the anti-atherosclerotic properties beyond its lipid-lowering effects. Thirty-six New Zealand male rabbits were randomly divided into low-cholesterol group (LC), high- cholesterol group (HC), high-cholesterol+ simvastatin group (HC+S) and then were fed for 12 weeks. At the end of the experiment, standard enzymatic assays, electrophoretic mobility shift as- say (EMSA), immunohistochemical staining, and morphometry were performed to observe serum lipids, NF-kB-DNA binding activity, MCP-1 protein expression, intirna thickness and plaque area of aorta respectively in all three groups. Our results showed that the serum lipids, NF-kB-DNA binding activity, expression of MCP-1 protein, intima thickness, and plaque area of aorta in the LC and HC+S groups were significantly lower than those in the HC group (P〈0.05). There was no significant difference in the serum lipids between the LC and HC+S groups (P〉0.05), but the NF-kB-DNA binding activity, the expression of MCP-1 protein and the intirna thickness and plaque area of aorta in the HC+S group were significantly decreased as compared to the LC group (P〈0. 05). This study demonstrated that simvastatin could decrease atherosclerosis by inhibiting the NF-kB-DNA binding activity and by reducing the expression of MCP-1 protein. 相似文献
42.
Nitin Aggarwal Deepti Sinha 《Indian journal of otolaryngology and head and neck surgery》2006,58(1):105-106
Foreign bodies in the esophagus are commonly seen in otolaryngologic practice. We report the successful removal of a working
wrist watch dial lodged for one month in the esophagus of an adult schizophrenic patient, which is a rare incident. 相似文献
43.
Sonal Dubey D.P. Jindal Poonam Piplani Louse C. Young Behrooz Fathi Alan L. Harvey 《Medicinal chemistry research》2005,14(4):229-240
This study reports the synthesis of steroidal quaternary ammonium compounds 11 and 12, with quaternary nitrogen at position 3 and 16 of the steroid nucleus in 5α-epiandrosterone series; along with their neuromuscular
blocking activity using chick biventer cervicis muscle preparation. The compound 12 was found to be five times more potent than 11 in reducing twitch response to nerve stimulations, indicating the importance of extended interonium distances and 17-acetoxy
function for potent antagonist activity. 相似文献
44.
Choudhary SK Saxena A Dubey B Kumar AS 《The Journal of thoracic and cardiovascular surgery》2000,120(1):148-155
OBJECTIVE: Retrospective analysis was performed to determine the suitability of pulmonary homograft as an aortic valve substitute. METHODS: From January 1994 through June 1999, 147 patients (mean age, 32.2 +/- 17.3 years) underwent aortic valve replacement with either an aortic homograft (group 1: n = 103, 25 fresh antibiotic preserved and 78 cryopreserved) or a pulmonary homograft (group 2: n = 44, 11 antibiotic preserved and 33 cryopreserved). In group 1 a scalloped subcoronary technique was used in 64 patients, and a root replacement technique was used in 39 patients. In group 2 the scalloped subcoronary technique was used in 34 patients, and the root replacement technique was used in 10 patients. RESULTS: There were 131 operative survivors (group 1 = 91; group 2 = 40). Follow-up ranged from 2 to 62 months. In group 1 none of the patients had significant aortic regurgitation during the hospital stay. Three patients (all having undergone the scalloped subcoronary technique) had moderate aortic regurgitation after 6 to 32 months. In group 2, 10 patients (9 having undergone the scalloped subcoronary technique and 1 having undergone the root replacement technique) developed significant regurgitation: 2 intraoperatively, 5 in the early postoperative period before discharge from the hospital, and 3 during late follow-up 6 to 12 months postoperatively. Among the various risk factors analyzed for overall homograft failure, use of a pulmonary homograft was the single independent predictor of valve failure (odds ratio, 8.6; 95% confidence interval, 1.9-39; P =.006). CONCLUSION: Pulmonary homograft, when inserted by means of a scalloped subcoronary technique, is not a suitable aortic valve substitute. 相似文献
45.
Sunil K. Dubey Jangala Hemanth Chiranjeevi Venkatesh K. R.N. Saha S. Pasha 《Journal of Pharmaceutical Analysis》2012,2(6):462-465
A simple, specific, precise, sensitive and rapid reverse phase-HPLC method was developed for determination of ketorolac enantiomers, a potent nonnarcotic analgesic in pharmaceutical formulations. The method was developed on a chiral AGP column. Mobile phase was 0.1 M sodium phosphate buffer (pH 4.5): Isopropanol (98:2, v/v), at a flow rate of 1 mL/min with run time of 15 min. Ultraviolet detection was made at 322 nm. The linearity range was 0.02–10 μg/mL for each of the enantiomers. The mobile phase composition was systematically studied to find the optimum chromatographic conditions. Validation of the method under the conditions selected showed that it was selective and precise and that the detector response was linear function of ketorolac. 相似文献
46.
47.
48.
49.
This review reconsiders evidence and strategies toward the prevention of consequential late rectal toxicity after radiation therapy, with a focus on prostate cancer. Novel clinical trial designs are encouraged, and these insights into the late effects of prostate radiation therapy have additional implications for late toxicity after cancer treatment for other tumors. 相似文献
50.