配戴眼镜与眼镜破损致眼外伤：附76例报告

本文报告５年间，在８２４例眼外伤中，对各种原因引起的眼镜破损致眼组织损伤７６例。以作业工人、中小学生高于其他职业。其中中小学生体育活动中引起眼镜破损致眼伤１７例，占体育运动时眼镜破损致伤１８例的９４．４４％。同时特别强调学生应正确配戴眼镜，以防在体育活动中，因不应或不需戴眼镜情况下发生眼镜破损致眼伤。     

Biotransformation of 4-methylcoumarins by cambial meristematic cells of Camptotheca acuminata

Cambial meristematic cell (CMC) suspension cultures were investigated as a new biotransformation system for the first time. Four 4-methylcoumarins substrates were transformed by CMCs of Camptotheca acuminata into four corresponding products, including 4,8-dimethylcoumarin-7-O-β-d-glucopyranoside (I-1), 4,7-dimethylcoumarin-6-O-β-d-glucopyranoside (II-1), 6-hydroxy-7-methoxyl-4- methylcoumarin (III-1), and 4,7-dimethylcoumarin-5-O-β-d-glucopyranoside (IV-1), of which I-1, II-1, and IV-1 were new compounds. In addition, the biotransformation time and the amount of substrate were investigated to compare the biotransformation rate and optimize the biotransformation conditions of the four substrates in C. acuminata CMCs suspension cultures. The results suggested C. acuminata CMCs were able to select glycosylate phenolic hydroxyl groups of 4-methylcoumarins I, II, and IV, with high regio- and stereoselectivity, but no corresponding glycoside of any phenolic hydroxyl group of compound III was detected. Simultaneously, the result also showed that the C. acuminata CMCs were able to transform the 7-hydroxy groups of substrate III to its corresponding methylated products. Furthermore, the monoamine oxidase (MAO) inhibition activities of biotransformed products were evaluated, and the data showed that all the products possessed good MAO inhibition activities in vitro. In conclusion, C. acuminata CMCs could be applied to glycosylation biotransformation as a novel plant-based system due to the successful application of bioconversion of exogenous coumarins.

Cambial meristematic cell (CMC) suspension cultures were investigated as a new biotransformation system for the first time.     

Effect of Volume Fraction of Reinforcement on Microstructure and Mechanical Properties of In Situ (Ti,Nb)B/Ti2AlNb Composites with Tailored Three-Dimensional Network Architecture

The mechanical properties of (Ti, Nb)B/Ti₂AlNb composites were expected to improve further by utilizing spark plasma sintering (SPS) and inducing the novel three-dimensional network architecture. In this study, (Ti, Nb)B/Ti₂AlNb composites with the novel architecture were successfully fabricated by ball milling the LaB₆ and Ti₂AlNb mixed powders and subsequent SPS consolidation. The influence of the (Ti, Nb)B content on the microstructure and mechanical properties of the composites was revealed by using the scanning electron microscope (SEM), transmission electron microscopy (TEM) and electronic universal testing machine. The microstructural characterization demonstrated that the boride crystallized into a B27 structure and the α₂-precipitated amount increased with the (Ti, Nb)B increasing. When the (Ti, Nb)B content reached 4.9 vol%, both the α₂ and reinforcement exhibited a continuous distribution along the prior particle boundaries (PPBs). The tensile test displayed that the tensile strength of the composites presented an increasing trend with the increasing (Ti, Nb)B content followed by a decreasing trend. The composite with a 3.2 vol% reinforcement had the optimal mechanical properties; the yield strengths of the composite at 25 and 650 °C were 998.3 and 774.9 MPa, showing an 11.8% and 9.2% improvement when compared with the Ti₂AlNb-based alloy. Overall, (Ti, Nb)B possessed an excellent strengthening effect and inhibited the strength weakening of the PPBs area at high temperatures; the reinforcement content mainly affected the mechanical properties of the (Ti, Nb)B/Ti₂AlNb composites by altering the α₂-precipitated amount and the morphology of (Ti, Nb)B in the PPBs area. Both the continuous precipitation of the brittle α₂ phase and the agglomeration of the (Ti, Nb)B reinforcement dramatically deteriorated the mechanical properties.     

再植指指屈肌腱粘连松解后的疗效分析

目的探讨断指再植后指屈肌腱粘连松解术的疗效。方法手指中、近节离断再植成活后，Ⅱ区指屈肌腱粘连的发生率高达９８％。对１６例２９指再植指鞘内指屈肌腱粘连行松解手术后配合积极的主动屈指功能训练及系列的康复治疗。结果经过３～１２个月的随访，疗效按ＴＡＭ评定标准评定，１７指达优良，优良率为５８．６％。８指为中，伤因均系绞轧伤或冲压伤。２例４指无效或失败，占１．４％。该２例虽为电锯伤，但失败１例术后过早开始作抗阻力锻炼，导致肌腱断裂。无效１例因术后未进行正确的功能锻炼。结论切割伤再植指屈肌腱作松解后的疗效优于绞轧伤再植指。肌腱松解术后进行系统的正规的康复治疗，有助于功能的恢复。术后２个月内不应作抗强阻力的锻炼。     

制药洁净厂房设备设施表面甲醛残留的测定

目前制药厂房仍普遍使用甲醛作为环境的消毒方式,但在厂房设施及设备表面的甲醛残留会对产品质量及人员安全造成危害。通过比较确定使用紫外吸光光度法进行检测,并对取样过程进行验证。     

精神分裂症病人入院MMPI测试分析与护理

目的:通过入院明尼苏达多相人格测定(简称MMPI),掌握病人心理状态、个性特点及精神病性症状,为护理诊断提供依据。方法:随机抽取100份入院初的MMPI测评,其中符合本研究要求的66份进行统计学处理并与中国常模对照。结果:研究组MMPI的效度量表F分和10个临床量表分与常模存在不同程度差异(P<0.05),测图呈现3/4合并6/8测图,与一般典型的精神分裂症测图有别。结论:当前入院精神分裂症病人由于受社会大环境及社区精神卫生网的影响,精神病性症状减轻或症状不典型或以类神经症表现为主。护理诊断应因人而异。     

Graves病患者外周血中树突状细胞及相关细胞因子的变化

目的检测Graves病人外周血细胞因子和树突状细胞(DCs)不同亚群的数量和表达情况,初步探讨DCs细胞亚群在疾病中的作用。方法利用流式细胞仪检测30例Graves病患者和30名健康体检者的外周血树突状细胞亚群数量,同时利用ELISA检测肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)、白细胞介素-2(IL-2)及IL-6等细胞因子的水平。结果测得Graves组髓样树突状细胞(p DC)和浆细胞样树突状细胞(m DC)值均高于正常对照组。ELISA检测细胞因子发现,Graves患者血清中TNF-α、IFN-γ、IL-6水平均高于正常对照组,其中TNF-α显著升高(P<0.01),而IL-2水平显著低于对照组(P<0.01)。结论 Graves病人中p DC和m DC水平升高,细胞因子分泌失调,Th1/Th2失衡,从而导致机体自身免疫反应的产生。     

Micronemal protein 13 contributes to the optimal growth of Toxoplasma gondii under stress conditions

Parasitology Research - Toxoplasma gondii is a ubiquitous parasitic protozoan infecting humans and a wide variety of animals. Fast-replicating tachyzoites during acute infection and slowly growing...     

性激素受体在牙龈瘤组织中的表述

本文采用免疫组织化学方法（ＡＢＣ法）对３４例牙龈瘤和２０例正常牙龈组织进行雌激素受体（ＥＲ）和孕激素受体（ＰＲ）检测．结果发现,牙龈瘤ＥＲ和ＰＲ的阳性率（８２％和６２％）明显高于正常牙龈组织（１５％和２５％）,而且阳性程度亦明显高于正常组（ｐ＜０．００１）．进一步研究发现,纤维型牙龈瘤ＥＲ和ＰＲ阳性率高于肉芽肿型牙龈瘤（ｐ＜０．０５）;女性正常牙龈组织中ＥＲ和ＰＲ的阳性率略高于男性．结果说明：正常牙龈组织中存在有特异性的性激素受体,牙龈瘤组织中ＥＲ和ＰＲ的明显增高可能说明在肿瘤的生长过程中存在着一定程度的性激素依赖性．     

高度近视性外伤性白内障手术联合后巩膜加固术疗效观察

目的 分析高度近视外伤性白内障摘出人工晶状体植入联合后巩膜加固术的效果。方法 观察29例29眼,随访时间最长为7年,最短为半年。为了分析疗效,随机抽查了10例10眼单纯做外伤性白内障摘出人工晶状体植入高度近视患者做为对照。结果 发现联合后巩膜加固术的接受白内障手术者术后视网膜并发症如网膜水肿出血、网脱等发生率明显低于对照组,两组对比差异有显著性意义。结论 联合手术是降低高度近视外伤性白内障术后视网膜并发症,提高手术安全度的有效方法。