Efficacy of systemic therapy in advanced pancreatic carcinoma

With a worldwide incidence of more than 200 000 cases and almost as many deaths, pancreatic carcinoma (PC) remains one of the leading causes of cancer deaths, especially in the Western world. Due to the late onset of symptoms, almost all patients suffer from disseminated disease at the time of diagnosis and only a minority will ever be candidates for radical surgery. Only about one tenth of the operated patients remain disease free. For these reasons, development of effective palliative systemic therapy is important. Almost a decade ago, gemcitabine replaced 5-Fu as the gold standard in systemic treatment of advanced PC. Since then, a number of trials have investigated the potential additional effect of several cytotoxic or targeted agents in combination with gemcitabine. As shown in this review, nearly all these trials have proved disappointing. This review provides an overview of the results of current phase III trials of gemcitabine based systemic therapy. Furthermore, we discuss the role of systemic therapy compared to BSC only and the potential future role of targeted therapies.     

Do shock absorbing insoles in recruits undertaking high levels of physical activity reduce lower limb injury? A randomized controlled trial

OBJECTIVES: To assess the benefits, if any, of the use of shock absorbing insoles in reducing lower limb injury among Air Force recruits, and to assess the differences, if any, in the efficacy of two commonly available shock absorbing insoles. DESIGN: Randomized controlled trial. SETTING: RAF Halton, UK. Site of all basic training for RAF personnel. PARTICIPANTS: 1205 recruits participating in basic training between 17 September 2003 and 7 April 2004. INTERVENTIONS: Participants were randomized to receive either standard issue Saran non-shock absorbing insoles, or shock absorbing Sorbothane or Poron insoles, on a 1:1:1 basis. MAIN OUTCOME MEASURES: The primary outcome measure was withdrawal from training for lower limb injury. The two primary comparisons were shock absorbing insole versus non-shock absorbing insole, and Sorbothane versus Poron (comparison of different shock absorbing insoles). Secondary outcomes were medical withdrawals for reasons other than those qualifying for the primary outcome measure. RESULTS: When comparing the non-shock absorbing insole to the shock absorbing insoles 72/401 participants (18.0%) allocated to Saran insoles were removed from training because of a qualifying lower limb injury, compared with 149/804 (18.5%) allocated to the shock absorbing insole (Sorbothane or Poron), odds ratio 1.04 (95% CI 0.75 to 1.44; P=0.87). When comparing the two shock absorbing insole 73/421 participants (17.3%) randomized to Sorbothane were removed from training because of a qualifying lower limb injury, compared with 76/383 for Poron (19.8%), odds ratio 0.85 (95% CI 0.58 to 1.23; P=0.37). CONCLUSIONS: Similar rates of lower limb injuries were observed for all insoles (shock absorbing and non-shock absorbing) in the trial. The trial provides no support for a change in policy to the use of shock absorbing insoles for military recruits.     

Marketing fat and sugar to children on New Zealand television

BACKGROUND: We aimed to determine the frequency and content of television food advertisements during children's viewing times on various New Zealand television channels. METHODS: A content analysis was conducted of two free-to-air channels covering a total of 155 h of television time during children's viewing times (n = 858 food advertisements in 2005). Comparisons were made with data from 1997 and data from Australia. RESULTS: Compared to Australian channels, both New Zealand channels (TV3 and TV2) had significantly higher proportions of food advertisements that were classified as being "high in fat and/or sugar" (54% versus 80% and 69%, respectively). Using a more detailed classification system, 70.3% of food advertisements on the New Zealand channels were for foods "counter to improved nutrition" (95% CI: 67.1%, 73.3%) compared to those "favoring improved nutrition" at 5.1% (95% CI: 3.8%, 6.9%). The number of food advertisements per hour was higher in 2005 than in 1997 for the channel (TV2) for which there was time trend data (12.8 versus 8.0 per hour for the afternoon time slot). CONCLUSIONS: These findings provide further evidence that the majority of food advertising on New Zealand television is counter to nutritional guidelines. They suggest the need for further regulatory or other controls.     

Balancing efficiency of health services and equity of access in remote areas in Greece

Data envelopment analysis (DEA) was used to investigate the efficiency of a set of small-scaled Greek hospitals known as hospital-health centers (HHCs). These facilities naturally provide primary and secondary care but are also expected to function as health centers addressing mostly preventive medicine, hygiene and other public health issues. They are located in remote rural areas and serve the relatively small local populations. This study aimed to obtain insight on their productive efficiency in light of their particular role. The sample consisted of 17 from the 18 units existing in the Greek NHS. Variables chosen to characterize production were numbers of doctors, nurses and beds as inputs, and admissions, outpatient visits and preventive medical services as outputs. The DEA model was input oriented, allowed for constant returns to scale and units were ranked according to a benchmarking approach. Analyses were performed with and without the preventive medicine variable and the results demonstrated technical inefficiencies 26.77 and 25.13%, respectively. Location appeared to affect performance, with remote units, e.g. on small islands, more inefficient. This raises the question if correcting reduced efficiency compromises equity of service access for highly dependent populations. Moreover, we observed superior performance of units additionally offering preventive medical services. This generates another question as to the role these facilities should play in our currently changing health care system.     

Patterns of hospital transfer for self-poisoned patients in rural Sri Lanka: implications for estimating the incidence of self-poisoning in the developing world

OBJECTIVES: Most data on self-poisoning in rural Asia have come from secondary hospitals. We aimed to: assess how transfers from primary to secondary hospitals affected estimates of case-fatality ratio (CFR); determine whether there was referral bias according to gender or poison; and estimate the annual incidence of all self-poisoning, and of fatal self-poisoning, in a rural developing-world setting. METHODS: Self-poisoning patients admitted to Anuradhapura General Hospital, Sri Lanka, were reviewed on admission from 1 July to 31 December 2002. We audited medical notes of self-poisoning patients admitted to 17 of the 34 surrounding peripheral hospitals for the same period. FINDINGS: A total of 742 patients were admitted with self-poisoning to the secondary hospital; 81 died (CFR 10.9%). 483 patients were admitted to 17 surrounding peripheral hospitals. Six patients (1.2%) died in peripheral hospitals, 249 were discharged home, and 228 were transferred to the secondary hospital. There was no effect of gender or age on likelihood of transfer; however, patients who had ingested oleander or paraquat were more likely to be transferred than were patients who had taken organophosphorus pesticides or other poisons. Estimated annual incidences of self-poisoning and fatal self-poisoning were 363 and 27 per 100,000 population, respectively, with an overall CFR of 7.4% (95% confidence interval 6.0-9.0). CONCLUSION: Fifty per cent of patients admitted to peripheral hospitals were discharged home, showing that CFRs based on secondary hospital data are inflated. However, while incidence of self-poisoning is similar to that in England, fatal self-poisoning is three times more common in Sri Lanka than fatal self-harm by all methods in England. Population based data are essential for making international comparisons of case fatality and incidence, and for assessing public health interventions.     

Breast carcinoma metastasizing to the urinary bladder presenting as bilateral hydronephrosis treated with ureteral stenting and chemotherapy

We describe a case of metastatic breast carcinoma involving the urinary bladder and causing bilateral hydronephrosis. Treatment consisted of bilateral renal decompression followed by chemoradiotherapy. The pertinent literature is reviewed.     

Effect of urbanicity of residence on TBI outcome at one year post-injury

OBJECTIVE: To determine the impact of urbanicity of residence and occurrence of medical complications on outcome after traumatic brain injury (TBI). STUDY DESIGN: A consecutive series of persons admitted for inpatient TBI rehabilitation followed for 1 year post-injury. SETTING: Inpatient brain injury rehabilitation programme in the southeastern US. PARTICIPANTS: One hundred and eleven persons with severe (67%), moderate (18%) or mild (15%) TBI. OUTCOME MEASURE: Functional status at 2 year post-injury as measured by the Disability Rating Scale (DRS). RESULTS: Functional status at follow-up was predicted by age, DRS at admission for rehabilitation, injury severity, alcohol use, continued need for medications and medical complications (validated R2 = 0.57; p < 0.0001). Urbanicity of residence was not predictive of functional status. CONCLUSIONS: As expected, participants who experienced more medical complications and required continued use of medications had poorer functional outcomes. Contrary to expectation, more rural residents did not have poorer outcomes than persons residing in more urban areas.     

Arginine and urea metabolism in the liver graft: A study using microdialysis in human orthotopic liver transplantation

BACKGROUND: Arginine is an amino acid having a central role in the metabolism of urea and nitric oxide in the liver. We present our findings of the behavior of these metabolites during the process of transplantation of the liver. METHODS: Urea, arginine, ornithine, citrulline, gamma-aminobutyric acid, glutamate, and glutamine levels in 15 livers were studied during the process of retrieval, following storage during the backtable procedure, and for 48 hours postreperfusion using microdialysis. Arginase levels in donor and recipient serum were also analyzed using an enzyme-linked immunosorbent assay specific for type I human arginase. Data was analyzed using one-way analysis of variance, with post-hoc comparison to the value at two hours using Dunnett's test (P < 0.05 significant). RESULTS: Levels of metabolites measured in the donor liver were seen to decline significantly in the stored liver. Immediately postreperfusion, there was a significant rise in arginase I levels in the recipient serum with low arginine levels recorded in the liver. The high arginase I levels significantly reduced six hours postreperfusion with a corresponding rise in extracellular arginine levels. Urea levels in the graft increased significantly immediately postreperfusion. CONCLUSIONS: Arginine levels were found to be low with correspondingly high serum arginase I levels in the early postreperfusion phase. High serum arginase I levels in early postreperfusion may influence nitric oxide production in this phase since considering Vmax and Km values, arginase I could compete with inducible nitric oxide synthase for arginine. Urea metabolism in the liver recommences immediately postreperfusion.