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51.
Friedrich Neurath 《Archives of orthopaedic and trauma surgery》1966,59(2):147-151
Ohne ZusammenfassungHerrn Prof. Dr. med. Dr. med. h. c. G. Hohmann in Verehrung zum 85. Geburtstag gewidmet. 相似文献
52.
Control of organ transplant-associated graft-versus-host disease by activated host lymphocyte infusions 总被引:3,自引:0,他引:3
Kuball J Theobald M Ferreira EA Hess G Burg J Maccagno G Barreiros AP Lüth S Schimanski CC Schuchmann M Schwarting A Neurath M Otto G Galle PR Lohse AW 《Transplantation》2004,78(12):1774-1779
BACKGROUND: Prolonged persistence of donor-derived T cells after organ transplantation has been proposed to improve long-term allograft survival. However, surviving transplant-derived T cells are also able to mediate devastating graft-versus-host disease (GvHD). Currently, GvHD after organ transplantation is usually refractory to conventional therapy and the disease outcome fatal. METHODS: Graft-reactive host T cells were generated ex vivo from a patient suffering from a severe and refractory liver-transplant-associated GvHD. To control GvHD, activated alloreactive host T cells were repetitively retransferred into the patient (activated host lymphocyte infusion [aHLI]). RESULTS: Adoptive transfer of ex vivo activated alloreactive host T cells (aHLI) led to the control and complete resolution of severe GvHD without inducing allograft rejection. CONCLUSIONS: aHLI opens a novel therapeutic window to control solid-organ transplant-associated GvHD while preserving allograft integrity. 相似文献
53.
O'Brien MF Connolly SS Kelly DG O'Brien A Quinlan DM Mulvin DW 《Irish journal of medical science》2004,173(1):23-26
Background Patients with prostate cancer with a pre-operative prostate-specific antigen (PSA) τ;15ng/ml who undergo radical retropubic
prostatectomy (RRP) generally do not have a good outcome, yet may have organ-confined cancer and should be offered the option
of surgery.
Aim To assess the outcome of patients who underwent RRP with a pre-operative PSA ≥ 15ng/ml.
Methods Thirty-four patients, mean pre-operative PSA: 25.46ng/ml (15.03–76.6) and mean Gleason score: 6.4 (5–9) were assessed.
Results Two groups were identified. Group I: 41% (14/34) have no biochemical recurrence to mean follow up of 58 months (30–106).
Mean PSA: 18.8ng/ml (15.03–25.84). Mean Gleason score: 6.1 (5–7). Clinical stage: T1c in 80%. No patient had seminal vesicle
or lymph node involvement. Group II: 59% (20/34) have biochemical recurrence or died (3) from their disease to mean follow
up of 66 months (36–98). Mean PSA: 28.9ng/ml (15.28–76.6). Mean Gleason score: 6.7 (5–9). Clinical stage: T1c in 25%. Eleven
patients had seminal vesicle (8) involvement or positive lymph nodes (3) or both (2).
Conclusion RRP seems feasible in patients whose pre-operative PSA is between 15 and 25ng/ml with stage T1c, Gleason score ≤ 7 and negative
lymph node frozen section. 相似文献
54.
Transplanting the genetic susceptibility to Crohn's disease 总被引:1,自引:0,他引:1
55.
56.
Duodenal somatostatinomas associated with von Recklinghausen's neurofibromatosis. Apropos of 2 cases
Cohen C Heymann MF Michenet P Memeteau F Saint-Marc O Emy P Maitre F Le Bodic MF 《Annales de pathologie》2000,20(6):609-611
Somatostatinomas are rare neuroendocrine tumors; they are essentially located in the pancreas and in the duodenum. The association with a neurofibromatosis type I is especially observed when the tumor is located in the ampulla of Vater. These tumors are not associated with a "somatostatin syndrome", but often present with gastrointestinal bleeding, abdominal pain and obstructive jaundice. The diagnosis is confirmed by immunohistochemical studies. The aim of this study is to report 2 cases of metastazing duodenal periampullary somatostatinomas associated with von Recklinghausen's disease and to discuss the prognosis of these tumors. Future genetic research are necessary as point out the familial feature of this association in one of our cases. 相似文献
57.
Neurath AR 《AIDS patient care and STDs》2000,14(4):215-219
Preferred microbicides are expected to inactivate most sexually transmitted viral and nonviral pathogens, including HIV-1, without affecting lactobacilli, components of the natural defense system against sexually transmitted diseases (STDs), be widely available, be inexpensive, and have an established safety record for human use. We show here that cellulose acetate phthalate [C-A-P enteric coating polymer (Eastman)], a compound used for coating of enteric tablets, meets all these criteria. 相似文献
58.
高效液相色谱法测定寒痹停片中士的宁含量 总被引:6,自引:0,他引:6
目的:建立用HPLC测定寒痹停片中士的含量的方法。方法:氰基柱;流动相-甲醇-水-三乙胺-乙酸(9800:155:15:30);紫外检测波长254nm。结果:在4~20ug/ml范围内,标准曲线回归方程为:Y=-2803+8967x(r=0.9997),RSD=1.65%?加样回收率的平均值为99.82%。结论:实验表明,这是一个适用于生产控制和产品质量检验的简单、快速、准确的方法。 相似文献
59.
MF Whitfield 《Archives of disease in childhood》1980,55(2):139-142
A third case of chondrodysplasia punctata after exposure to warfarin alone in early pregnancy is described. The clinical course of the child during the first 18 months is outlined. The use of warfarin in early pregnancy must be avoided because of its established teratogenic effects in causing this syndrome, in addition to an overall increase in perinatal mortality. 相似文献