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91.
A Lacout M El Hajjam C Julie P Lacombe JP Pelage 《Journal of Medical Imaging and Radiation Oncology》2008,52(6):580-582
We report the case of a patient with a single liver metastasis of a mucinous colonic carcinoma that mimics a haemangioma in T2‐weighted sequences. Although a very high T2 signal in non‐cystic lesions is highly specific for the diagnostic of haemangioma, the use of gadolinium‐enhancement MRI is recommended. In patients with a history of neoplasia, the diagnosis of benign liver nodules should be made with caution. 相似文献
92.
The frequency of reversible and irreversible visual impairment was determined in children with severe and profound sensorineural deafness, as subnormal vision can adversely affect their educational and social development. Eighty three of 87 such children attending an audiology service were examined to assess the incidence and severity of visual impairment. Each child underwent a detailed ophthalmic assessment. The criteria for visual impairment were visual acuity < 6/9 Snellen or equivalent and/or abnormal binocular vision. Forty five had a normal ophthalmic examination (54.2%). Twenty nine had visual impairment (34.9%) and nine had ophthalmological abnormalities that did not interfere with vision (10.9%). A higher proportion of children with risk factors for visual pathology demonstrated visual impairment than those in whom there were no risk factors. None the less, 44% of visual impairment was among patients without risk factors. The results underline the need to examine all children with severe and profound sensorineural deafness soon after diagnosis and indicate that children with multiple handicaps have a greater likelihood of visual impairment (11 of 14 cases). 相似文献
93.
G Larcos SM Gruenewald JP Fletcher 《Journal of Medical Imaging and Radiation Oncology》1995,39(3):254-256
Recent observations suggest that first degree relatives of patients with an abdominal aortic aneurysm (AAA) are also at risk for the development of this disorder. The first degree relatives of 130 adults with known AAA were invited to attend for an ultrasound examination. Fifty-two eligible relatives (mean age 53 years, range 41–73) from 38 families underwent sonographic screening. Using standard ultrasound criteria no participants were identified with an asymptomatic AAA. Thus, ultrasound of families of patients with AAA has a low yield and may not be useful for screening purposes. 相似文献
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95.
Polk HC Bowden TA Rikkers LF Balch CM Organ CH Murie JA Pories WJ Buechler M Neoptolemos JP Fazio VW Schwartz SI Cameron JL Kelly KA Grosfeld JL McFadden DW Souba WW Pruitt BA Johnston KW Rutherford RB Arregui ME Scott-Conner CE Warshaw AL Sarr MG Cuschieri A MacFadyen BV Tompkins RK 《Surgical endoscopy》2002,16(6):1019-1020
96.
Complications of pancreatic cancer resection 总被引:21,自引:0,他引:21
Halloran CM Ghaneh P Bosonnet L Hartley MN Sutton R Neoptolemos JP 《Digestive surgery》2002,19(2):138-146
Pancreatic cancer is a common cause of cancer death in the developed world. Currently, resection is the only chance of long-term survival. The post-operative mortality in nonspecialist centres often exceeds 20% but is around 6% or less in specialist centres. The overall complication rate even in specialist centres is 18-54%. An analysis of eleven large series of pancreatic resections shows an incidence of common complications of 10.4% for fistula, 9.9% for delayed gastric emptying, 4.8% for bleeding, 4.8% for wound infection and 3.8% for intra-abdominal abscess. The median hospital stay is 13-18 days in different series. The re-operation rate varies from 4 to 9% with a mortality rate of 23 to 67%. Major complications are a significant factor in post-operative mortality, especially if they require re-operation. The use of octreotide or somatostatin to prevent complications is supported by several multicentre, double-blind, randomized controlled trials. The best way to improve outcome is to concentrate pancreatic cancer care in regional specialist centres. 相似文献
97.
Polk HC Bowden TA Rikkers LF Balch CM Organ CH Murie JA Pories WJ Buechler MW Neoptolemos JP Fazio VW Schwartz SI Cameron JI Kelly KA Grosfeld JL McFadden DW Souba WW Pruitt BA Johnston KW Rutherford RB Arregui ME Scott-Conner CE Warshaw AL Sarr MG Cuschieri A Tompkins RK MacFadyen BV 《Annals of surgical oncology》2002,9(5):421-422
98.
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100.
SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis 总被引:11,自引:0,他引:11
Pfützer RH Barmada MM Brunskill AP Finch R Hart PS Neoptolemos J Furey WF Whitcomb DC 《Gastroenterology》2000,119(3):615-623
BACKGROUND & AIMS: Gain-of-function trypsin mutations cause acute pancreatitis and chronic pancreatitis. Loss of trypsin inhibitor function may have similar effects. We investigated the prevalence of SPINK1 (PSTI) mutations in familial pancreatitis, idiopathic chronic pancreatitis, and controls. METHODS: Genetic-linkage studies were performed in 5 familial pancreatitis families. The entire SPINK1 gene was sequenced in 112 affected individuals and 95 control DNA samples, and exon 3 was sequenced in 95 additional controls. X-ray crystallography-based model building and statistical studies were performed. RESULTS: Significant linkage between pancreatitis and 5q31.1-2 was excluded. Novel SPINK1 mutations, one D50E mutation, one IVS3+125 C>A, and five IVS3+184 T>A intronic polymorphisms were identified. The N34S and P55S mutations were observed in 29 of 112 patients (25%) as N34S/N34S (n = 7), N34S/wt (n = 19), N34S/P55S (n = 2), and N34S/D50E (n = 1). Three hundred eighty control alleles revealed 3 N34S (0.77%), 2 P55S (0.53%), and no D50E mutations. Age of disease onset and severity were similar between homozygous and heterozygous patients. Structural modeling revealed several possible pathophysiologic mechanisms for the N34S mutation. CONCLUSIONS: SPINK1 mutations are common in the population (approximately 2%), but are clearly associated with pancreatitis. The mutation-associated risk is low. Modeling and familial clustering suggest that SPINK1 mutations are disease modifying, possibly by lowering the threshold for pancreatitis from other genetic or environmental factors, but by themselves do not cause disease. 相似文献