全文获取类型
收费全文 | 357篇 |
免费 | 11篇 |
专业分类
儿科学 | 7篇 |
妇产科学 | 1篇 |
基础医学 | 77篇 |
口腔科学 | 3篇 |
临床医学 | 31篇 |
内科学 | 40篇 |
皮肤病学 | 3篇 |
神经病学 | 24篇 |
特种医学 | 25篇 |
外科学 | 38篇 |
综合类 | 36篇 |
预防医学 | 33篇 |
眼科学 | 9篇 |
药学 | 30篇 |
肿瘤学 | 11篇 |
出版年
2021年 | 4篇 |
2019年 | 4篇 |
2018年 | 5篇 |
2017年 | 4篇 |
2016年 | 6篇 |
2015年 | 4篇 |
2014年 | 13篇 |
2013年 | 11篇 |
2012年 | 12篇 |
2011年 | 11篇 |
2010年 | 22篇 |
2009年 | 18篇 |
2008年 | 10篇 |
2007年 | 11篇 |
2006年 | 8篇 |
2005年 | 7篇 |
2004年 | 9篇 |
2003年 | 6篇 |
2002年 | 3篇 |
2001年 | 9篇 |
1999年 | 6篇 |
1998年 | 15篇 |
1997年 | 7篇 |
1996年 | 6篇 |
1995年 | 6篇 |
1994年 | 11篇 |
1993年 | 4篇 |
1992年 | 4篇 |
1991年 | 13篇 |
1990年 | 15篇 |
1989年 | 14篇 |
1988年 | 6篇 |
1987年 | 8篇 |
1986年 | 7篇 |
1985年 | 8篇 |
1984年 | 2篇 |
1980年 | 4篇 |
1978年 | 4篇 |
1976年 | 6篇 |
1975年 | 2篇 |
1972年 | 4篇 |
1971年 | 2篇 |
1970年 | 3篇 |
1969年 | 3篇 |
1968年 | 4篇 |
1967年 | 6篇 |
1966年 | 2篇 |
1959年 | 2篇 |
1939年 | 2篇 |
1936年 | 2篇 |
排序方式: 共有368条查询结果,搜索用时 15 毫秒
311.
James V Lavery Sunita VS Bandewar Joshua Kimani Ross EG Upshur Frances A Plummer Peter A Singer 《BMC public health》2010,10(1):384
Background
A central question in the debate about exploitation in international research is whether investigators and sponsors from high-income countries (HIC) have obligations to address background conditions of injustice in the communities in which they conduct their research, beyond the healthcare and other research-related needs of participants, to aspects of their basic life circumstances. 相似文献312.
313.
In this study, we applied for real-time PCR the two-standard system that we had worked out previously for PCR with gel-detection of products. Genomic DNA of a known concentration was used as external standard and mRNA of the DNA-dependent RNA-polymerase II was used as internal standard. It was shown that PCR with gel-detection of products and real-time PCR provide similar results and demonstrate almost identical accuracy and repeatability when the two-standard system is used. With the help of the both methods and using the two-standard system we have confirmed the link between the genetically determined freezing reaction in mice and reduced 5-HT1A receptor mRNA level in the midbrain. We have also found that the genetically determined freezing reaction in mice is not connected with changes in Tph2 gene expression. 相似文献
314.
Tikhonova MA Kulikov AV Naumenko VS Morozova MV Bazovkina DV Popova NK 《Bulletin of experimental biology and medicine》2009,148(6):889-891
Single administration of brain-derived neurotrophic factor (BDNF) into the lateral ventricle of ASC mice (Antidepressant Sensitive
Catalepsy), a model of depression-like state, significantly decreased predisposition to cataleptic freezing in these animals.
These findings indicate that BDNF can appear as a promising antidepressant of new generation and that ASC mice can be used
as an adequate model for investigations of the mechanisms of behavior modification by BDNF. 相似文献
315.
Kulikov AV Osipova DV Naumenko VS Terenina E Mormède P Popova NK 《Behavioural brain research》2012,233(1):113-119
The neurotransmitter serotonin (5-HT) is involved in the regulation of mouse intermale aggression. Previously, it was shown that intensity of mouse intermale aggression was positively associated with activity of the key enzyme of 5-HT synthesis - tryptophan hydroxylase 2 (TPH2) in mouse brain. The aim of the present study was to investigate the effect of pharmacological activation or inhibition of 5-HT synthesis in the brain on intermale aggression in two mouse strains differing in the TPH2 activity: C57BL/6J (B6, high TPH2 activity, high aggressiveness) and CC57BR/Mv (BR, low TPH2 activity, low aggressiveness). Administration of 5-HT precursor L-tryptophan (300 mg/kg, i.p.) to BR mice significantly increased the 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) levels in the midbrain as well as the number of attacks and their duration in the resident-intruder test. And vice versa, administration of TPH2 inhibitor p-chlorophenylalanine (pCPA) (300 mg/kg, i.p., for 3 consecutive days) to B6 mice dramatically reduced the 5-HT and 5-HIAA contents in brain structures and attenuated the frequency and the duration of aggressive attacks. At the same time, L-tryptophan or pCPA did not influence the percentage of aggressive mice and the attack latency reflecting the threshold of aggressive reaction. This result indicated that the intensity of intermale aggression, but not the threshold of aggressive reaction is positively dependent on 5-HT metabolism in mouse brain. 相似文献
316.
The dopamine D3 receptor gene (DRD3) is considered being one of the candidate genes contributing to the development of tardive dyskinesia (TD). In a recent meta-analysis with mixed ethnicities, only a barely positive association was found between the functional DRD3 Ser9Gly polymorphism and TD in patients with schizophrenia (OR = 1.17; 95% CI: 1.01-1.37; p = 0.041). To further evaluate the controversial association between the polymorphism and TD using only Japanese subjects, we tested the association in a case-control design. We also conducted a meta-analysis including 8 studies with 3 East Asian populations (Japanese, Chinese, and Korean). In our Japanese case-control sample (43 with TD/157 without TD), we found no association between the DRD3 Ser9Gly polymorphism in schizophrenia and TD (genotype: p = 0.92; allele: p = 1.00). Furthermore, no significant difference in the mean AIMS score among the three genotypic groups was observed in our sample. The meta-analysis comprising 1291 East Asian subjects also showed no association between the polymorphism and TD; the Mantel-Haenszel pooled OR for TD among carriers of the DRD3 Ser9Gly of the eight Asian studies was 0.94 (95% CI: 0.78-1.12). Overall, our results suggest that the DRD3 Ser9Gly polymorphism may not confer susceptibility to TD in East Asian populations. Given that the Ser9Gly variant may play a putative role in the DRD3 function, further studies on the DRD3 are warranted. 相似文献
317.
318.
This review addresses a question at the junction of neurophysiology and neurogenetics – the multiplicity of types and subtypes
of serotonin (5-HT) receptors and their roles in the physiological effects of the brain neurotransmitter serotonin. Particular
attention is paid to comparison of the behavioral effects of related subtypes of 5-HT receptors – 5-HT1 (5-HT1A and 5-HT1B) and 5-HT2 (5-HT2A and 5-HT2C) receptors – which are involved in the mechanisms regulating behavior and psychopathology. Published data are presented,
along with results obtained at the Laboratory for Behavioral Neurogenics, providing evidence that different types of 5-HT
receptors can act in different directions as well as similarly, supplementing each other, in the control of physiological
functions and behavior. The roles of 5-HT1A and 5-HT1B receptors in regulating aggressive behavior, sexual arousal, drinking behavior, and food consumption are discussed. Experimental
results demonstrating reciprocal relationships between 5-HT2A and 5-HT2C receptors and interactions between 5-HT1A and 5-HT3 receptors are presented. These data provide evidence of a complex system for these interactions not only at the receptor
level, but also with the involvement of genes controlling the main elements of the serotonin system. Interaction of receptors
evidently underlies neuroplasticity and plays a significant role in compensatory processes and in adaptive mechanisms. 相似文献
319.
LV Naumenko VA Kuznetsov AA Spasov AV Muravyev IA Tikhomirova FA Khaliullin VA Anisimova 《Bulletin of experimental biology and medicine》2012,153(2):209-211
We studied the impact of compounds RU-1202 and SUM-55 on electrophoretic mobility of “young” and “old” erythrocytes fractionated in a density gradient. The test compounds are shown to increase electrophoretic mobility of erythrocytes, compound SUM-55 being superior to the reference drug pentoxifylline. 相似文献
320.