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81.
Ibrahim Noha Hosni Fawzy Iman Mahmoud Gouda Tahany Mahmoud El Sayed Rasha Abdel Hameed Morsi Maha Hosni Sabry Al Shimaa Mohamed Hashaad Nashwa Ismail 《Clinical rheumatology》2022,41(11):3401-3409
Clinical Rheumatology - Systemic sclerosis (SSc) is an autoimmune disorder that causes vasculopathy and scarring, most commonly in the lungs and skin, but it can also affect other organs.... 相似文献
82.
Dahlia A. Hussein Samah A. El Bakry Nashwa A. Morshedy Soha E. Ibrahim Hossam Moussa Sakr Rania A. Abo-Shady 《The Egyptian Rheumatologist》2018,40(4):221-226
Aim of the work
To assess the level of serum cartilage oligomeric matrix protein (COMP) in early rheumatoid arthritis (RA) patients and study its relation to disease activity and musculoskeletal ultrasound (MSUS) findings.Patients and methods
The study included 40 early RA patients. Disease activity score (DAS28) was assessed. Serum COMP level was measured and MSUS findings of the small joints of hands done at base line and after 6?months of follow up.20 age and sex matched control were included.Results
Patients age was 38.8?±?9.3?years; 36 females and 4 males and disease duration 6.7?±?3.5?years. Serum COMP was significantly higher in patients (median 190?U/L; 90–750?U/L) compared to control (90?U/L; 80–130?U/L)(p?<?.001) being higher in more active (250?U/L) (p?=?.001) and significantly correlated with baseline synovial inflammation (p?=?.009). COMP levels were lowered after 6?months of receiving treatment (110 U/L; 30–180?U/L) (p?<?.001). The presence of bony erosions increased with more active disease (p?=??.003). There was a significant reduction in the erythrocyte sedimentation rate and COMP at follow up (p?<?.0001 and p?=?.001 respectively). No correlation was found between the COMP level with C-reactive protein, ESR, MSUS score or bony erosions at follow up.Conclusions
COMP significantly correlated with disease activity in early RA and could be used as a marker of activity. It correlates significantly with synovial inflammation detected by power Doppler. COMP may reflect the outcome and could be used as a prognostic marker in RA patients. COMP did not significantly correlate with bone erosions. 相似文献83.
Yasser Emad Yasser Ragab Nevin Hammam Nashwa El-Shaarawy Ossama Ibrahim Rania M. Gamal Magdy Abd-Elsalam Reem H.A. Mohammed Mona Hawass Johannes J. Rasker 《Reumatología clinica》2021,17(5):250-257
ObjectivesTo study the frequency of different autoantibodies to extractable nuclear antigens (ENAs) in rheumatoid arthritis (RA) patients and to correlate findings with clinical manifestations, disease activity and radiological damage.MethodsA total of 230 RA patients were included and 75 healthy controls. In all patients rheumatological assessment was done and routine laboratory investigations and immune profile were performed in both patients and controls, including: RF, ACPA, ANA and anti-ENAs (Ro/SSA, La/SSB, U1-RNP, anti-Jo-1 and anti-Sm). Radiological damage was scored using Sharp/van der Heijde, and disease activity was evaluated by DAS28-ESR and DAS28-CRP.ResultsRF was positive in 101 (43.9%), ACPA in 220 (95.7%), ANA in 58 (25.2%), anti Ro in 31 (13.5%), anti-La in 10 (4.3%), anti-Jo1 in 5 (2.2%) and anti-RNP in 2 (0.9%). Anti-Ro/SSA positively correlated with sicca symptoms (p = .02), RF titer (p < .001), ANA (p < .001), DAS28-ESR (p = .026), and DAS28-CRP (p = .003). Anti-La antibodies correlated positively with SJC (p = .001), TJC (p = .001), ANA (p < .001), DAS-28 ESR (p = .007). Anti-Jo-1 correlated positively with interstitial lung disease (ILD) (p ≤ .001), RF titer (p = .037) and ANA (p ≤ .001). Anti-RNP antibodies correlated positively with disease duration (p ≤ .001), ACPA titer (p ≤ .001) and ANA (p = .014). In the controls ANA was positive in two (2.7%), anti-Ro in three (4%), and none of the controls tested positive for other autoantibodies.ConclusionsIn RA patients, positive ANA is frequent and positively associated with anti-Ro, anti-La and anti-Jo1 autoantibodies. Screening for autoantibodies against other anti-ENAs seems mandatory in RA patients especially when ANA is positive. RA cases with positive Anti-Jo-1 may develop anti synthetase syndrome and ILD. 相似文献
84.
Shokeir AA Hussein AA Soliman SA Kamal MM Abdel-Aziz A Awadalla A Rahim MA Barakat N 《BJU international》2012,110(6):904-911
What's known on the subject? and What does the study add? It is known that the kidney damage continues even after release of ureteric obstruction. This study found that giving ferulic acid, antioxidant, after release of ureteric obstruction enhanced the recovery of kidney functions in solitary kidney.
OBJECTIVE
- ? To evaluate the effect of ferulic acid (FA) on the recovery of renal function and renal damage after relief of partial ureteric obstruction (PUO) of a solitary kidney.
METHODS
- ? Male mongrel dogs (n= 32) were classified into three groups: sham (eight), control (12) and study (12).
- ? A right nephrectomy was carried out and dogs in the study and control groups were subjected to 4 weeks of PUO.
- ? Serum creatinine, creatinine clearance (CrCl) and renographic clearance (RC) were measured at baseline, after 4 weeks of obstruction and 8 weeks after relief of obstruction.
- ? Markers of lipid peroxidation (malondialdehyde [MDA]), superoxide dismutase (SOD), and reduced glutathione (GSH), and immunostaining of markers of apoptosis (caspase 3 and Bcl2), cell proliferation (Ki67) and interstitial fibrosis in the kidney were evaluated at the end of experiment.
RESULTS
- ? Ferulic acid enhanced the recovery of serum creatinine, CrCl and RC by an extra 22%, 26% and 33.7%, respectively, of the basal values at 8 weeks, after relief of 4 weeks' obstruction.
- ? In addition, FA caused a significant decrease in MDA and a significant increase in GSH and SOD.
- ? Ferulic acid also significantly reduced the interstitial fibrosis, and caspase 3 expression, and significantly increased the expression of Bcl2 and Ki67 in kidney tissues at 8 weeks after relief of the obstruction.
CONCLUSION
- ? Ferulic acid enhances the recoverability of renal function and minimizes the renal damage through reduction of oxidative stress, tubular apoptosis and the interstitial fibrosis in the solitary kidney after relief of PUO.
85.
Nashwa M. Abd-Allah Gihan Omar Nadia Elameen Rabab A.S. Mousa 《The Egyptian Rheumatologist》2018,40(3):191-195
Aim of the work
To assess the diagnostic value of salivary gland ultrasonography (SGUS) for Sj?gren's syndrome (SS) and to compare it with minor salivary gland biopsy (MSGB) in patients with sicca symptoms.Patients and methods
Thirty patients with suspected SS (sicca symptoms only) were included in the study. The diagnosis of SS was confirmed according to the 2012 American College of Rheumatology criteria. SGUS was performed for all patients and the bilateral echostructure of the parotid and submandibular glands were graded from 0 to 3. SGUS score ≥2 was considered abnormal. A complete work up for SS was performed in all patients including a standardized clinical examination performed by the same rheumatologist, serological and laboratory tests, ocular tests and MSGB. Schirmer’s test and the Ocular Staining Score (OSS) using rose Bengal were performed.Results
Of the 30 patients, 10 had primary sicca symptoms (mean age 42.3 ± 13.1 years) and 20 secondary (49.5 ± 8.6 years) and most were females. The frequency of SS syndrome by ACR criteria was 6.7%. By adding ultrasound item to ACR criteria (SGUS score ≥2) the frequency of SS syndrome increased to 10%. The SGUS (cutoff score ≥2) showed a sensitivity of 66.6% and a specificity of 85.2% for SS diagnosis. Histopathology of MSGB showed no significant correlation with SGUS scores and remained the most diagnostic method for SS that had sensitivity and specificity of 100%.Conclusion
SGUS is a noninvasive method with high diagnostic value for diagnosis of primary and secondary SS. 相似文献86.
Ghada El Rahmawy Doaa Rashwan Nashwa Nabil Mohamed 《Egyptian Journal of Anaesthesia》2013,29(4):357-361
ObjectiveThe aim of this study was to evaluate the efficacy of prophylactic pregabalin on postdural puncture headache incidence and severity after spinal anesthesia.Method86 ASA I-II male and female patients age 20–50 years old, undergoing elective general surgeries below the umbilicus under spinal anesthesia with 3 ml heavy bupivacaine 0.5% (15 mg), patients were randomly allocated into one of two groups (Group C, n = 43) (control group) received a placebo capsule 2 h preoperatively (Group P, n = 43) received 150 mg pregabalin capsule 2 h preoperatively, number of attempts for spinal block, sensory level, motor block grade, postoperative time to first analgesic requirement, the incidence, onset and intensity of PDPH and adverse events were recorded for 72 h.ResultsThe peak sensory level in C group and P group showed no statistical significant difference, the time to peak sensory block was significantly earlier in P group than group C, the time to reach the modified Bromage motor block grade 3 was significantly earlier in P group than C group, time to two segment regression of sensory level to S1 and motor block regression to modified Bromage grade 0 were statistically insignificant between the studied groups. Group P had a significantly longer time to first analgesic requirements than group C, and there was no significant difference in VAS (visual analogue scale) of pain between the studied groups. There was significant increase in sedation score in P group compared to C group at 2 h and 6 h postoperatively, and there was statistically significant reduction in the incidence rate and severity of PDPH in P group compared to group C. There were no recorded cases of dizziness, visual disturbances, or PONV.Conclusionspreoperative oral pregabalin 150 mg reduced the incidence and severity of PDPH, beside the earlier onset of peak sensory and motor block with increase duration of analgesia in patients undergoing elective surgeries under spinal anesthesia. 相似文献
87.
88.
Nashwa K. Radwan Waleed Nemr 《Journal of tissue engineering and regenerative medicine》2020,14(9):1272-1280
Skin ulcers are non‐healed wounds caused by inflammation of epidermis up to the dermis, which causes pain and limits body movements, significantly reducing quality of life. Amniotic membrane is a placental collagenous biomaterial with many biological and mechanical properties important for tissue engineering and regenerative medicine. The aim of this work is to evaluate the efficacy of topical antibiotic washing followed with irradiated human amniotic membrane (iHAM) dressing for treating five different types of ulcers. The current study included 15 patients who were recruited from the outpatient clinic of the Egyptian Atomic Energy Authority. Follow up of all treated cases that completed the regimen was up to 3 months. The clinical progression of all treated ulcers was quantitatively evaluated by computerized estimation of the wound size reduction based on 3D image analysis. All cases in this study showed great outcomes within several weeks of treatment depending on wound infection, ulcer depth and size, period of healing disorder, age, blood glycemia, and other clinical criteria. Patients' questionnaires revealed that pain was controlled by the first time of treatment. After 1 week post‐treatment, granulation tissue was generated and observed in all patients, and all microbial colonies have been eliminated from wounds with previous infection. The current study indicated that the dressing of ulcers with iHAM induces fast healing without complication. 相似文献
89.
Background:
Most atopic dermatitis (AD) patients have elevated serum immunoglobulin E (IgE). Impaired folic acid (FA) metabolism was found to reduce the intracellular methyl donor pool, associated with a higher prevalence of atopy.Aim:
To assess serum IgE and FA in AD patients and to correlate their levels with the disease severity, and with each other.Materials and Methods:
Twenty patients with AD were assessed for serum FA and IgE, compared with 20 age- and sex-matched controls. Patients were classified into three groups (mild, moderate, and severe AD) based on clinical severity according to Nottingham index. In both patients and controls, serum IgE was measured using Enzyme-linked immunosorbent assay technique and serum FA was measured using Microparticle Enzyme Immunoassay technique.Results:
Serum FA levels were lower in AD patients compared with controls, but the difference was not statistically significant. FA levels did not show statistically significant difference among disease severity groups and did not correlate with serum IgE levels. On the other hand, serum IgE levels were significantly elevated in AD patients compared with controls, and among AD patients, its levels were significantly elevated in severe AD compared with mild and moderate disease.Conclusion:
Serum IgE is useful in assessment of AD severity and activity. FA contribution to AD needs further investigations. 相似文献90.
Nashwa E. Hassan Hussein A. El-Orabi Yara M. Eid Neema R. Mohammed 《Middle East Fertility Society Journal》2012,17(3):176-180
ObjectivesTo investigate the correlation between the levels of 25-hydroxyvitamin D and insulin resistance in patients with polycystic ovarian syndrome (PCOS).Patients and methodsIn 30 untreated PCOS patients and 15 control subjects, levels of 25-hydroxyvitamin D were measured. In addition, endocrine and metabolic variables were evaluated and a glucose tolerance test was performed to assess indices of insulin resistance.ResultsObese PCOS women (n = 15) had lower 25-hydroxyvitamin D levels than lean PCOS women (n = 15) and control subjects (8.9 ± 3.1 vs 26.5 ± 6.4 vs 79.2 ± 19.1 nmol/l respectively; P < 0.001). In the entire cohort, 25-hydroxyvitamin D levels were negatively correlated with body mass index (r = ?0.390), fasting insulin (r = ?0.707), HOMA-β (r = ?0.705), and HOMA-IR (r = ?0.635), and positively correlated with QUICKI (r = 0.723) (all P < 0.001).ConclusionIn PCOS women, low 25-hydroxyvitamin D levels are associated with obesity and insulin resistance. 相似文献