全文获取类型
收费全文 | 280篇 |
免费 | 16篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 14篇 |
妇产科学 | 6篇 |
基础医学 | 31篇 |
口腔科学 | 4篇 |
临床医学 | 20篇 |
内科学 | 43篇 |
皮肤病学 | 20篇 |
神经病学 | 17篇 |
特种医学 | 12篇 |
外科学 | 68篇 |
综合类 | 3篇 |
预防医学 | 13篇 |
眼科学 | 4篇 |
药学 | 16篇 |
中国医学 | 1篇 |
肿瘤学 | 20篇 |
出版年
2023年 | 2篇 |
2021年 | 6篇 |
2020年 | 3篇 |
2019年 | 3篇 |
2018年 | 6篇 |
2017年 | 5篇 |
2016年 | 6篇 |
2015年 | 7篇 |
2014年 | 8篇 |
2013年 | 7篇 |
2012年 | 9篇 |
2011年 | 9篇 |
2010年 | 4篇 |
2009年 | 4篇 |
2008年 | 10篇 |
2007年 | 17篇 |
2006年 | 8篇 |
2005年 | 10篇 |
2004年 | 8篇 |
2003年 | 6篇 |
2002年 | 6篇 |
2001年 | 8篇 |
2000年 | 10篇 |
1999年 | 7篇 |
1998年 | 6篇 |
1996年 | 4篇 |
1995年 | 3篇 |
1994年 | 2篇 |
1993年 | 4篇 |
1992年 | 6篇 |
1991年 | 9篇 |
1990年 | 8篇 |
1989年 | 10篇 |
1988年 | 12篇 |
1987年 | 11篇 |
1986年 | 15篇 |
1985年 | 10篇 |
1984年 | 6篇 |
1983年 | 2篇 |
1979年 | 3篇 |
1975年 | 1篇 |
1974年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1967年 | 1篇 |
1966年 | 1篇 |
1935年 | 1篇 |
排序方式: 共有296条查询结果,搜索用时 46 毫秒
61.
Kitagawa H Pringle KC Koike J Nagae H Zuccollo J Sato Y Seki Y Fujiwaki S Wakisaka M Nakada K 《Pediatric surgery international》2006,22(11):875-879
Vesico-amniotic shunting of obstructive uropathy in fetal lambs produced a thick-walled, poorly compliant bladder. We report the early histological changes in the obstructed bladder wall. We created an obstructive uropathy in fetal lambs at 60 days gestation by ligating the urethra and urachus. Vesicostomy or vesico-amniotic shunt tube insertion and biopsy of the bladder wall were performed 21 days later. The fetuses were delivered at term (145 days) and the kidneys and bladder sampled for histology. Colloidal iron (Col Fe), and alpha-smooth muscle actin (α-SMA) immunohistochemical stains were used for these samples. Seventeen fetuses were shunted with 15 biopsies taken at that time. Six (shunt failure or missed urachal ligation) were excluded. All biopsies taken at shunting had positive Col Fe and α-SMA. Term lambs had mild multicystic dysplastic kidney (MCDK) in five, severe MCDK in two, and hydronephrosis in four. All bladders had small volume and were severely fibrotic. Fetal shunt operations 3 weeks after the creation of obstructive uropathy provided partial preservation of renal histology but did not preserve normal bladder histology. We suggest that the high hyaluronic acid synthesis activity or hyperplasia of the myofibroblasts in the dilated fetal bladder wall at the time of shunting results in irreversible damage to the developing bladder muscle and fibrosis. 相似文献
62.
63.
64.
65.
E Taniguchi Y Nagae H Watanabe Y Ohashi S Kinoshita R Manabe 《Nippon Ganka Gakkai zasshi》1991,95(1):52-58
Recent advances in genetic engineering techniques have enabled large-scale manufacture of human epidermal growth factor (hEGF), making possible the clinical use of this particular agent in treating a variety of corneal epithelial disorders. In view of future application to humans, it has to be determined whether hEGF could induce neovascularization in the cornea upon topical instillation, since the angiogenic effect of mouse EGF on the cornea in vivo has been reported. For this, a sheet of slow-release form polymer (EVA) containing hEGF was surgically implanted into the rabbit corneal stroma in search for subsequent corneal neovascularization. EVA sheets contained one of the following agents: (1) 250ng hEGF, (2) 500ng hEGF, (3) 250ng bFGF (positive control), (4) vehicle alone (negative control). On 5 and 14 days after implantation, the corneas were excised, sectioned, and stained with hematoxylin and eosin for histological evaluation. Slit lamp examination revealed that marked neovascularization developed in the corneas when EVA sheets containing bFGF were implanted. A number of polymorphonuclear leukocytes were accumulated around the implants. However, neovascularization did not occur in the corneas when EVA sheets containing either concentrations of hEGF or vehicle alone were implanted. Only a few polymorphonuclear leukocytes infiltrated. This result indicates that as much as 500ng hEGF does not induce corneal neovascularization. 相似文献
66.
Masaaki Nagae Hiroyuki Umegaki Joji Onishi Chi Hsien Huang Yosuke Yamada Kazuhisa Watanabe Hitoshi Komiya Masafumi Kuzuya 《Nutrients》2020,12(11)
Chronic dehydration mainly occurs due to insufficient fluid intake over a lengthy period of time, and nursing home residents are thought to be at high risk for chronic dehydration. However, few studies have investigated chronic dehydration, and new diagnostic methods are needed. Therefore, in this study, we aimed to identify risk factors for chronic dehydration by measuring serum osmolality in nursing home residents and also to evaluate whether examining the inferior vena cava (IVC) and determining the IVC collapsibility index (IVC-CI) by ultrasound can be helpful in the diagnosis of chronic dehydration. A total of 108 Japanese nursing home residents aged ≥65 years were recruited. IVC measurement was performed using a portable handheld ultrasound device. Fifteen residents (16.9%) were classified as having chronic dehydration (serum osmolality ≥295 mOsm/kg). Multivariate logistic regression analysis showed that chronic dehydration was associated with dementia (odds ratio (OR), 6.290; 95% confidential interval (CI), 1.270–31.154) and higher BMI (OR, 1.471; 95% CI, 1.105–1.958) but not with IVC or IVC-CI. Cognitive function and body weight of residents should be considered when establishing a strategy for preventing chronic dehydration in nursing homes. 相似文献
67.
Koji Fukumoto Naoto Urushihara Hiroaki Fukuzawa Akihide Sugiyama Hideki Nagae Kentaro Watanabe Maki Mitsunaga Satoshi Akazawa Shiro Hasegawa 《Pediatric surgery international》2011,27(1):67-71
Laryngotracheal separation is often performed to prevent intractable aspiration for children with severe mental and physical
disabilities. However, tracheo-innominate artery fistula after surgery can occur as a severe complication and cause fatal
hemorrhage. We have therefore developed a novel procedure to prevent tracheo-innominate artery fistula. Surgery was performed
by making an H-shaped incision and creating skin flaps. The trachea was not raised anteriorly and the skin flaps were sutured
to the trachea. We performed this procedure on nine patients, and no major complications occurred in any case. This procedure
can be expected to reduce the occurrence of tracheo-innominate artery fistula. 相似文献
68.
S. Kanazawa T. Nagae K. Fukuda I. Katsu N. Mukai Y. Sugihara H. Otani Y. Higami T. Tsunoda 《International journal of clinical oncology / Japan Society of Clinical Oncology》2000,5(1):57-61
We report a case of a rare inflammatory disease, granulomatous lobular mastitis. Two weeks prior to admission the patient,
a 43 year-old woman, (gravida 1, para 1) had noticed a left breast mass associated with tenderness. Palpation, gross inspection,
and clinical examination, as well as the rapid growth of the mass lesion led us to believe that it was highly suspicious of
malignant neoplasm. Mammography, ultrasonography, and computed tomography did not differentiate it from a malignant neoplasm.
Aspiration cytology revealed an inflammatory lesion with a few clusters of epithelial cells it was diagnosed as borderline
malignancy(class III) by a prudent pathologist, and thus mastectomy was performed. However, the final histologi-cal diagnosis
was granulomatous lobular mastitis with no evidence of malignancy. As the clinical manifestations of granulomatous mastitis
are similar to those of mammary carcinoma and, as it is an inflammatory lesion of uncertain etiology and pathogenesis, it
has often been mistaken clinically for carcinoma and treated as such. Our review of the literature indicated that granulomatous
mastitis most often occurs in young patients with a history of childbirth or oral contraceptive usage. Recurrence was documented
in 38% of patients, and, accordingly long-term follow-up by aspiration cytology, complete resection, and adequate drug treatment
with corticosteroids are recommended.
Received: January 6, 1999 / Accepted: September 22, 1999 相似文献
69.
70.
Okada M Ota T Okura H Abe Y Ichiba N Yoh H Nagae K Yanagi S Hirota K Yoshikawa J 《Journal of cardiology》2001,37(5):277-283
A 25-year-old woman was admitted to our hospital with goiter. The diagnosis was Grave's disease. Diagnostic transthoracic echocardiography revealed a hyperdynamic stage of the heart with right ventricular dilation. Doppler echocardiography showed mild to moderate tricuspid regurgitation and elevated systolic right ventricular pressure. Right heart catheterization revealed high cardiac output (9.49 l/min) and pulmonary hypertension (57 mmHg) with increased pulmonary vascular resistance and total pulmonary resistance. No intracardiac shunts were detected. Since neither thiomazole nor propylthiouracil was effective and both caused side effects, she underwent subtotal thyroidectomy. After the surgery, pulmonary hypertension improved and cardiac output normalized, but without normalization of pulmonary vascular resistance and total pulmonary resistance. Reversible pulmonary hypertension may occur in patients with hyperthyroidism. Increased pulmonary blood flow and sustained high pulmonary artery resistance were suspected as the causes of pulmonary hypertension. In addition, pulmonary endothelial dysfunction as a result of sustained increased pulmonary blood flow could be another cause of pulmonary hypertension. 相似文献