个性化音乐疗法结合中医情志护理对ICU患者心理及睡眠的影响

目的:探究个性化音乐疗法结合中医情志护理对ICU患者心理和睡眠的改善效果。方法:将123例ICU患者依据随机数字表法分为2组,对照组61例采用常规护理联合中医情志护理干预,观察组62例在对照组的基础上采用个性化音乐疗法。对比2组护理前后心理状态评分、睡眠质量、住院时间、ICU综合征发生情况和护理满意度。结果:观察组出院时,抑郁、躯体化、焦虑、人际关系敏感、强迫症状、敌对、偏执方面评分优于对照组,差异有统计学意义(P<0.05);在精神病性、恐怖方面比较,差异无统计学意义(P>0.05)。与护理前比较,2组睡眠质量评分较前改善(P<0.05),观察组出院时,入睡时间、睡眠质量及睡眠质量总分明显优于对照组,差异有统计学意义(P<0.05)。观察组住院时间、ICU综合征发生率及护理满意度明显优于对照组,差异有统计学意义(P<0.05)。结论:个性化音乐疗法结合中医情志护理在ICU病患的心理健康状态方面的调整有积极的影响,对病患的睡眠情况的改善也有很好的帮助,降低了ICU综合征发生率,缩短了住院时间。     

Dietary Plant Protein Intake Can Reduce Maternal Insulin Resistance during Pregnancy

Evidence suggests that the source of dietary protein may have an impact on insulin resistance, but no studies have explored it in pregnant populations. In this study, we combined a population study and an animal experiment to explore this effect. The population study was conducted with data from NHANES. Multiple linear regression was used to observe the association of protein intake with outcomes, including fasting glucose (GLU), insulin (INS), and HOMA-IR. In the animal experiment, 36 pregnant SD rats in three groups were orally administered 100% animal protein, 50% animal protein and 50% plant protein, or 100% plant protein, respectively. The intervention continued throughout the whole pregnancy. On day 19.5, maternal plasma was collected after overnight fasting, and metabolomics was performed using UPLC-MS. We found plant protein intake was negatively correlated with INS and HOMA-IR in the whole population. During the third trimester, a similar correlation was also observed. The animal experiment also presented the same result. In metabolomic analysis, changes in various metabolites and related pathways including FoxO and mTOR signaling pathways were observed. In conclusion, we found a negative association between dietary plant protein intake and maternal insulin resistance during pregnancy. Changes in some active substances and related metabolic pathways may play an important role.     

Regulatory T cells in inflammation and resolution of acute lung injury

IntroductionAcute respiratory distress syndrome (ARDS) is characterized by hypoxemia and increased lung permeability and would result in acute respiratory failure and with high mortality. In patients who survive from acute lung injury (ALI)/ARDS, it is an active process of the transition from injury to resolution depending on the coordinated immune system. The roles of regulatory CD4⁺T cells (Tregs) are now gradually being clarified during inflammation and resolution of ARDS. However, clear conclusions about roles of Tregs in ALI/ARDS are only a few.ObjectiveThis review provides an overview of phenotype, differentiation, and suppressive mechanisms of Tregs and focuses on keys of biology of Tregs in alveolar space during the inflammatory response and resolution of ALI/ARDS.Data SourceLiterature search of Web of Science, PubMed, and EMBASE was made to find relative articles about Tregs in ALI/ARDS. We used the following search terms: Tregs, ALI, ARDS, inflammation, and resolution.ConclusionMore and more studies have indicated Tregs involved in the processes of inflammation and resolution of ALI/ARDS. A deep understanding of the roles of Tregs may indicate new treatments for patients of ARDS. Therapies aimed at expansion or adaptive transfer of Tregs could be an effective therapy to ARDS patients.     

糖尿病肾病病人醛糖还原酶基因多态性相关研究

目的探讨醛糖还原酶（AR）基因5’端（AC）n多态性与2型糖尿病肾病的关系。方法采用聚合酶链反应（PCR）、聚丙烯酰胺凝胶电泳及银染色技术分析了139例2型糖尿病病人（早期糖尿病肾病组61例,非糖尿病肾病组78例）和63例正常对照者AR基因5’端（AC）n的多态性。结果早期糖尿病肾病组Z-2等位基因频率高于非糖尿病肾病组和正常对照组（x^2=6．88、10．51,P〈0．01）;含Z～2等位基因的基因型频率也高于非糖尿病肾病组和正常对照组（X^2=4．95、8．15,P〈0．05、0．01）。结论AR基因Z-2等位基因与青岛地区汉族2型糖尿病病人糖尿病肾病的发生发展有关。     

正颌术后严重甲状腺功能减退症1例

甲状腺功能减退症是一种常见的全身代谢减低的内分泌疾病,初诊很少发生在口腔颌面外科.因其症状无特异性,临床上极易漏诊、误诊,从而造成严重后果.本文报道1例以呼吸道阻塞、颌面部肿胀、贫血和双足水肿为主要特征的正颌术后严重甲状腺功能减退症病例,并结合文献,探讨甲状腺功能减退症的危险因素、临床表现、诊断及治疗.     

从“线粒体-肠道菌群交互作用”探讨益气化痰通络法治疗缺血性中风

线粒体结构的完整性及功能被破坏是缺血性脑卒中的主要病理环节之一。"线粒体-肠道菌群交互作用"体现了中医整体观,是人体气与血,正与邪,气机运行和病理产物之间平衡与失衡的一个体现。线粒体功能障碍、肠道菌群失调与中医"气虚""痰浊""瘀血"的机理有相似之处。益气化痰通络法可通过保护线粒体、干预肠道菌群的作用调节机体的气血平衡,达到益气化瘀、补气化痰、活血通络、扶正祛邪的作用。     

描述性分类法用于门诊护理管理的效果观察

目的 探究描述性分类法应用于门诊护理管理的效果以及应用价值。方法 以简单随机抽样法纳入32名门诊护理人员作为研究对象,2018年1—12月未实施描述性分类法管理,设置为参照组,2019年1月—2020年1月后实施描述性分类法管理,设置为管理组,以统计学对两组管理期间护理活动量表评分（nursing activities score,NAS）、护理水平、不良事件发生情况以及管理满意度等数据进行处理分析。结果 管理组卫生保健、活动和体位、管理和输液、患者和家属支持与护理、行政和业务管理工作等护理活动方面的评分明显高于参照组,差异有统计学意义（P <0.05）。管理组护理技术评分、护理态度评分、护理质量评分均明显高于参照组,差异有统计学意义（P <0.05）。管理组发生意外伤害、护理差错、护患纠纷以及投诉等不良事件发生率6.25%明显低于参照组25.00%,差异有统计学意义（P <0.05）。管理组门诊护理人员满意度明显高于参照组,差异有统计学意义（P <0.05）。结论 描述性分类法应用于门诊护理管理中可提高管理期间护理活动以及护理水平,减少各种不良事件的发生,护理...     

新药研发项目成本管理面临的问题及对策

目的 意在提高对新药研发项目管理的重视,认识加强成本管理是新药研发的关键环节.方法 采用文献查阅法和网上信息搜集法等方法,分析了新药研发项目成本管理中遇到的一些问题.结论 提出了改善新药研发项目成本管理的几点对策.     

中医护理慢性湿疹

慢性湿疹常由于急性或亚慢性湿疹的治疗不当,造成湿疹长期不愈或反复发作。病因复杂、诊断分型多样、治疗棘手。现对近年来中医药对慢性湿疹护理进行研究分析。     

淫羊藿黄酮对去势大鼠骨生物力学性能的影响

目的：探讨淫羊藿黄酮对去势大鼠骨生物力学性能的影响。方法：选用2月龄雌性SD大鼠60只,随机分为6组,每组10只。A组：空白对照组,常规方法饲养,进行假手术处理;B组：去势组,不给予淫羊藿黄酮干预;C组：去势垣钙剂,每日灌服高效钙（75 mg·kg-1）垣维生素D3 21 IU·kg-1;D组：去势垣低剂量,每日灌服淫羊藿黄酮（75 mg·kg-1）;E组：去势垣中剂量,每日灌服淫羊藿黄酮（150 mg·kg-1）;F组：去势垣高剂量,每日灌服淫羊藿黄酮（300 mg·kg-1）。实验第4月末处死大鼠,取出大鼠双侧胫骨、双侧股骨、双侧肱骨和全部腰椎。实验动物干预完毕后测定：淤第四腰椎体力学性能指标中弹性模量、最大载荷、最大应力、变形位能、结构刚度,于股骨结构力学性能指标中最大载荷、破坏载荷、变形位能、结构刚度,盂股骨材料力学性能指标中弹性模量、最大应力、最大应变、破坏应力、破坏应变。结果：与B组比较,A、D、E、F组第四腰椎体力学性能指标中弹性模量、最大载荷、最大应力、变形位能、结构刚度,股骨结构力学性能指标中最大载荷、破坏载荷、变形位能、结构刚度,股骨材料力学性能指标中弹性模量、最大应力、最大应变、破坏应力明显升高（P<0.05）;C组有升高趋势;A、C、D、E、F组之间比较差异没有统计学意义;D、E、F组随淫羊藿黄酮剂量的增加而增加,但其相互之间差异没有统计学意义;股骨材料力学性能指标中破坏应变A、C、D、E、F组之间相互比较差异没有统计学意义;表明去势造成了大鼠椎骨力学性能,股骨结构力学性能和股骨材料力学性能的降低,应用淫羊藿黄酮可改善第四腰椎体力学性能、股骨结构力学性能和股骨材料力学性能。结论：淫羊藿黄酮可有效防治去势大鼠骨生物力学性能的降低,使其维持在较高水平。