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71.
Atrophic rhinitis is a chronic, debilitating and recalcitrant disease of the nasal cavities that is prevalent in several parts of the world. It has unique epidemiological features and clinical characteristics. Clinicians and researchers for decades have tried to postulate theories for the aetiology of the primary form of the disease. Management of the disease has seen several medical therapeutic regimens including alternative forms of medicine. Surgical options for the condition are also not completely satisfactory with a number of failures and recurrences. The authors provide here a comprehensive review of the existing literature as regards the aetiology and management of this refractory condition. 相似文献
72.
Mitochondria play a central role in heart metabolism and function. Administration of antineoplastic drug cyclophosphamide (CP) adversely affects the heart mitochondria which may result in cardiotoxicity. The present study is aimed at evaluating the role of lipoic acid (LA) in CP induced myocardial injury. Male albino rats of Wistar strain were used for the study. CP was administered as a single intraperitoneal injection (200 mg/kg BW). A decrease in the activities of TCA cycle enzymes such as succinate dehydrogenase, malate dehydrogenase and isocitrate dehydrogenase was noted in CP treated rats. Simultaneously there was a decrease in the activities of mitochondrial complexes of electron transport chain. Decrease in the activities of these enzymes suggests a loss in mitochondrial function and integrity. Ultrastuctural observations were also in agreement with the above abnormal changes. Loss of myofilaments and damage of mitochondrial cristae revealed the cytotoxic effect of CP. The supplementation of LA (25 mg/kg BW) restored the above abnormalities to near normalcy. The study brings out the importance of LA in improving the mitochondrial function in cardiac cells after CP administration. 相似文献
73.
Sudharsan PT Mythili Y Sudhahar V Varalakshmi P 《The Journal of pharmacy and pharmacology》2005,57(11):1437-1444
Cyclophosphamide, an alkylating agent widely used in cancer chemotherapy, causes fatal cardiotoxicity. In this study, lupeol, a pentacyclic triterpene isolated from Crataeva nurvala stem bark, and its ester, lupeol linoleate, were investigated for their possible hypocholesterolaemic effects against cyclophosphamide-induced lipidaemic instabilities. Male albino Wistar rats were categorized into 6 groups. Group I served as control. Rats in groups II, V and VI were injected intraperitoneally with a single dose of cyclophosphamide (200 mg kg(-1)) dissolved in saline. Cyclophosphamide-treated groups V and VI respectively received lupeol and lupeol linoleate (50 mg kg(-1)), dissolved in olive oil, for 10 days by oral gavage. Groups III and IV served as drug controls and were administered lupeol and lupeol linoleate, respectively. Cyclophosphamide administration induced abnormal changes in serum lipoproteins and lipid fractions in both serum and cardiac tissue. The activity of lipid metabolizing enzymes was distorted significantly in the cyclophosphamide-treated rats. The cyclophosphamide-treated rats also showed extensive intermuscular haemorrhage in histology. Lupeol and its ester reversed the above alterations induced by cyclophosphamide. This study encapsulates the early lipaemic abnormalities in the heart tissue of cyclophosphamide-treated rats. Treatment with lupeol linoleate was more effective than lupeol in rendering protection to the cardiac tissue challenged by cyclophosphamide. 相似文献
74.
75.
Bhaskaran M Sengottaiyan A Madhu S Ranganathan V 《Indian journal of physiology and pharmacology》2006,50(3):225-233
Abacus is a method used by Chinese, Japanese and Koreans to improve mathematical skills. This system has now invaded our country. The improvement in mathematical skills is said to be due to a coordinated functioning of both right and left hemisphere. As learning and memory in any field is achieved by coordinating and analyzing the different sensory inputs, whether an abacus trainee would also improve the short-term memory as a whole was evaluated in our study. 50 children of average IQ between 5 and 12 years from 2 regular schools and 50 from an abacus institute were evaluated for short-term memory before and after a period of one and two years. The memory tests were taken from Wechsler memory scale, Mini mental state examination, Mann - Buitar visual memory screen for objects. The results showed that the abacus learners at the end of one and two years had a better visual and auditory memory when compared to non-abacus learners. 相似文献
76.
Mythili Ayyagari Sita Ramu Chitela Venkateswarlu Kolachana 《Annals of Indian Academy of Neurology》2012,15(2):101-105
Introduction:
Women with epilepsy (WWE) have an increased risk for several endocrine disorders. Obesity and Polycystic Ovarian Syndrome (PCOS) are common side-effects of anticonvulsant drugs.Aim:
To study the prevalence of Obesity, PCOS, Thyroid dysfunction in WWE on monotherapy with Carbamazepine (CBZ), Sodium Valproate (VAL) and Phenytoin (DPH)Material and Methods:
Sixty WWE in the reproductive age group (13 – 45 yr) who are on atleast 6 months of monotherapy with either CBZ (20) or VAL (20) or DPH (20) are subjects of the study. Their Anthropometric data is recorded. They are interviewed and investigated for PCOS and thyroid dysfunction. Twenty healthy women in the reproductive age group served as controls. BMI>25 is taken as cut-off for Obesity. PCOS is defined as menstrual irregularity and/or clinical /biochemical hyperandrogenism with ultrasound evidence of PCO as per the Rotterdam criteria. TSH <0.1 and >4 is taken as evidence of thyroid dysfunction. Women are grouped according to the anticonvulsant drug received and the data analyzed in each group.Results:
The mean BMI among VAL and CBZ users is significantly higher than among DPH users (23.3 & 23.4 vs 20.4). There is no significant difference in incidence of PCOS among WWE using either DPH or VAL or CBZ. Elevated TSH>4 is seen more often in WWE on VAL (9/20) compared to CBZ (6/20) and DPH (3/20). WWE on CBZ, VAL and DPH did not differ in mean BMI, Obesity, PCOS compared to healthy controls. As compared to healthy controls, more WWE on drug therapy had significantly elevated TSH (1/20 vs20/60).Conclusions:
WWE on VAL and CBZ had significant weight gain compared to DPH users. Despite weight gain, there was no difference in the incidence of PCOS between the users of VAL, CBZ and DPH. As compared to healthy controls, more WWE on drug therapy had significantly elevated TSH, more so in the VAL group. 相似文献77.
78.
Sunil Goyal Kiran Natarajan Amarnath Devarasetty T. Sarankumar Neha Chauhan Mohan Kameswaran 《Medical Journal Armed Forces India》2018,74(1):65-71
Background
Ear and the lateral skull base surgery is challenging and yet fascinating for a Neuro-otologist. A thorough knowledge of the complex anatomy is indispensable for the surgeon in order to provide the best possible care.Methods
The aim of the study was to highlight the present day indications for translabyrinthine approach to IAM from a Neuro-otologist perspective.Results
There were a total of 7 patients who underwent Translabyrinthine approach at our centre. In the present study we have reported cases of Vestibular Schwannoma, Facial nerve schwannoma, Cholesteatoma involving the IAM, Meniere's disease with refractory vertigo which were managed via translabyrinthine approach. We also encountered, probably the first reported case, tuberculoma of the IAM which was clinical suspected to be vestibular schwannoma.Conclusion
The article presents different clinical situations where this approach can be suitably utilized and has been dealt with via a retrospective study encountered at our centre. 相似文献79.
Donepudi Ashrita Ayyagari Mythili 《International journal of diabetes in developing countries.》2019,39(3):585-589
International Journal of Diabetes in Developing Countries - The effective management of Type 1 Diabetes (T1D) involves self-management practices and education about self-monitoring of blood glucose... 相似文献
80.
Shyam Sudhakar Sudarsan Vijaya Krishnan ParamasivanSenthil Vadivu Arumugam Sathiya MuraliMohan Kameswaran 《International journal of pediatric otorhinolaryngology》2014