全文获取类型
收费全文 | 10183篇 |
免费 | 576篇 |
国内免费 | 73篇 |
专业分类
耳鼻咽喉 | 71篇 |
儿科学 | 235篇 |
妇产科学 | 129篇 |
基础医学 | 1075篇 |
口腔科学 | 136篇 |
临床医学 | 1099篇 |
内科学 | 2431篇 |
皮肤病学 | 170篇 |
神经病学 | 539篇 |
特种医学 | 233篇 |
外国民族医学 | 2篇 |
外科学 | 1882篇 |
综合类 | 250篇 |
现状与发展 | 1篇 |
一般理论 | 5篇 |
预防医学 | 610篇 |
眼科学 | 325篇 |
药学 | 899篇 |
中国医学 | 168篇 |
肿瘤学 | 572篇 |
出版年
2024年 | 17篇 |
2023年 | 183篇 |
2022年 | 571篇 |
2021年 | 720篇 |
2020年 | 423篇 |
2019年 | 522篇 |
2018年 | 526篇 |
2017年 | 331篇 |
2016年 | 368篇 |
2015年 | 399篇 |
2014年 | 475篇 |
2013年 | 610篇 |
2012年 | 922篇 |
2011年 | 812篇 |
2010年 | 392篇 |
2009年 | 372篇 |
2008年 | 553篇 |
2007年 | 546篇 |
2006年 | 475篇 |
2005年 | 427篇 |
2004年 | 349篇 |
2003年 | 301篇 |
2002年 | 155篇 |
2001年 | 58篇 |
2000年 | 40篇 |
1999年 | 38篇 |
1998年 | 30篇 |
1997年 | 15篇 |
1996年 | 23篇 |
1995年 | 11篇 |
1994年 | 7篇 |
1993年 | 9篇 |
1992年 | 14篇 |
1991年 | 14篇 |
1990年 | 7篇 |
1989年 | 9篇 |
1988年 | 8篇 |
1987年 | 5篇 |
1985年 | 8篇 |
1984年 | 13篇 |
1983年 | 6篇 |
1982年 | 6篇 |
1981年 | 13篇 |
1980年 | 6篇 |
1979年 | 6篇 |
1978年 | 7篇 |
1976年 | 4篇 |
1969年 | 3篇 |
1968年 | 3篇 |
1967年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 11 毫秒
11.
Duane retraction syndrome has been reported in association with structural abnormalities of the eye, including epibulbar dermoid, keratoconus, iris dysplasia, heterochromia iridis, persistent fetal vasculature, cataract, choroidal coloboma, microphthalmia, and optic nerve dysplasia. A novel association, that of bilateral Duane syndrome with bilateral aniridia, is the subject of this report. 相似文献
12.
Y. H. K. Lodhi R. Kingston O. Brady 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2007,17(2):199-201
Compression of median nerve at elbow secondary to loose body is very rare, only two cases have been reported in literature. Elbow swelling in this case led us to the cause of our patient’s median nerve dysfunction. A simple day case elbow arthroscopy procedure, and removal of loose body provided a cure for the elbow symptoms and the neuropathy. Compression neuropathy at the elbow, while rare, should be considered in the differential diagnosis of hand paraesthesia. 相似文献
13.
14.
Muhammad Al-Kaylani Peter Konrad Barry Lazenby Bennett Blumenkopf Bassel Abou-Khalil 《Seizure》2007,16(2):95-98
Data are limited on seizure recurrence after antiepileptic drug (AED) discontinuation in operated seizure-free patients. We reviewed seizure outcome in patients who came off AEDs after being seizure-free for 2 years following temporal lobe surgery in our center. Thirty-nine (68%) of 57 patients who discontinued AED therapy remained seizure-free. They had a younger age at surgery than the group with seizure recurrence (p=0.01). Earlier surgery may be a favorable predictor for seizure freedom after AED discontinuation. 相似文献
15.
BACKGROUND: We assessed suicide and suicide attempt risk as well as symptom reduction among 3,282 depressed patients participating in duloxetine and escitalopram clinical trials assigned to either an antidepressant or placebo. METHODS: We reviewed the FDA Summary Basis of Approval reports for data regarding safety and efficacy for duloxetine and escitalopram. Furthermore, we compared suicide risk among antidepressant clinical trials in this study with our two previous analyses on seven antidepressant clinical trials. RESULTS: Suicide and suicide attempt risk varied considerably among the three analyses, showing up to ten fold differences. Interestingly, the variability exists across the three reports, rather than between treatments (antidepressants versus placebo). CONCLUSIONS: These findings suggest caution in generalizing suicide risk even from a relatively large number of participants and thus, firm conclusions can only be drawn if the number of participants is overwhelmingly large (approximately two million patients). We also noted similar magnitude of response to placebo and antidepressants among the three studies. 相似文献
16.
Muhammad F Dawwas James D Lewsey James M Neuberger Alexander E Gimson 《Liver transplantation》2007,13(8):1115-1124
Modification of the current allocation system for donor livers in the United States to incorporate recipient serum sodium concentration ([Na]) has recently been proposed. However, the impact of this parameter on posttransplantation mortality has not been previously examined in a large risk-adjusted analysis. We assessed the effect of recipient [Na] on the survival of all adults with chronic liver disease who received a first single organ liver transplant in the UK and Ireland during the period March 1, 1994 to March 31, 2005 (n=5,152) at 3 years, during the first 90 days, and beyond the first 90 days, adjusting for a wide range of recipient, donor, and graft characteristics. Compared to those with normal [Na] (135-145 meq/L; n=3,066), severely hyponatremic recipients ([Na]<130 meq/L, n=541), had a higher risk-adjusted mortality at 3 years (hazard ratio [HR] 1.28; 95% confidence interval [CI], 1.04-1.59; P<0.02). The excess mortality was, however, confined to the first 90 days (HR 1.55; 95% CI, 1.18-2.04; P<0.002) with no significant difference thereafter. This was also true for hypernatremic recipients ([Na]>45 meq/L, n=81), who had an even greater risk-adjusted mortality compared to normonatremic recipients (overall: HR 1.85; 95% CI, 1.25-2.73; P<0.002; 90 days: HR 1.12; 95% CI, 0.55-2.29; P=0.8), whereas mildly hyponatremic recipients ([Na] 130-134 meq/L, n=1,127) had similar risk-adjusted mortality to those with normal [Na] at the same time points. In conclusion, recipient [Na] is an independent predictor of death following liver transplantation. Attempts to correct the [Na] toward the normal reference range are an important aspect of pretransplantation management. 相似文献
17.
18.
19.
20.
Parkash J Chaudhry MA Rhoten WB 《The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology》2005,286(2):982-993
The migration of macrophages and lymphocytes that produce cytokines such as tumor necrosis factor-alpha (TNF-alpha) causes beta-cell death, leading to type 1 diabetes. Similarly, in type 2 diabetes, the adipocyte-derived cytokines including TNF-alpha are elevated in the circulation, causing inflammation and insulin resistance. Thus, the studies described in this article using TNF-alpha are relevant to furthering our understanding of the pathogenesis of diabetes mellitus. We used RINr1046-38 (RIN) insulin-producing beta-cells, which constitutively express calbindin-D(28k), to characterize the effect of TNF-alpha on apoptosis, replication, insulin release, and gene and protein expression. Western blots of TNF-alpha-treated RIN cells revealed a decrease in calbindin-D(28k). By ELISA, TNF-alpha-treated beta-cells had 47% less calbindin-D(28k) than controls. In association with the decline in calbindin-D(28k), TNF-alpha treatment of RIN cells led to a 73% greater increase in changes in intracellular calcium concentration (Delta[Ca(2+)](i)) in TNF-alpha-treated cells as compared to that in control RIN cells upon treatment with 50 mM KCl; caused a greater increase in the [Ca(2+)](i) following the addition of 5.5 microM ionomycin; increased by more than threefold the apoptotic rate, expressed as the percentage of TUNEL-positive nuclei to total nuclei; decreased the rate of cell replication by 36%; and increased and decreased selectively the expression of specific genes as determined by microarray analysis. The subcellular localizations of Bcl-2, an antiapoptotic protein, and Bax, a proapoptotic protein, within RIN cells were altered with TNF-alpha treatment such that the two were colocalized with mitochondria in the perinuclear region. We conclude that the proapoptotic action of TNF-alpha on beta-cells is manifested via decreased expression of calbindin-D(28k) and is mediated at least in part by [Ca(2+)](i). 相似文献