肘关节后脱位并尺骨冠状突骨折9例临床疗效分析

目的 探讨肘关节后脱位并尺骨冠状突骨折的治疗方法。方法 总结2000年3月～2003年5月9例肘关节后脱位合并尺骨冠状突骨折患者的治疗经验，根据骨折类型分别采用内外侧入路对8例患者进行手术治疗，术后配合早期功能锻炼。结果 所有患者随访8～24个月，根据HSS评分标准，优5例（55.6%)，良2例（22.2%)，一般2例（22.2%)，优良率77.8%，无严重肘关节并发症发生。结论 选择恰当的手术入路和早期功能锻炼是提高该类骨折效果的关键。     

静脉药物配置中心的建立在临床中的应用

静脉输液药物集中配置、管理是我国医院管理的一项新举措.长期以来,临床静脉输液中的加药工作一直是由护士在治疗室独立完成,这种方式存在着很多不足之处.在这种环境污染下,职业健康安全管理越来越受到各国政府的重视.为了提高服务质量,预防和控制可能存在的环境污染及职业健康安全风险,国家颁布 GB/T24001～ 1996<环境管理体系规范和使用指南>, GB/T28001-2001<职业健康安全管理体系规范>标准,引进国外的先进管理模式,此项工作由药师和护士共同完成,以期达到合理用药减少药物的流失和浪费,科学配置、降低输液反应.静脉药物配置中心把静脉药物配置从普通环境的治疗室转为在具有洁净条件的配置中心进行集中管理配置,保证配置出来的药品安全无菌、有效.需要输液的患者在舒适、整洁和安静的环境下进行输液,减少临床护理工作量的目的,把更多的时间还给病人.这为顺利实施静脉配置中心的项目提供了保障,确保了输液中心正常运行.     

Mitochondrial encephalomyopathies: biochemical approach.

Thanks to recent advances in the molecular genetics of mitochondrial encephalomyopathies, we can now begin to correlate genetic lesions with biochemical defects. In the fatal infantile myopathy due to cytochrome c oxidase (COX) deficiency, an autosomal recessive condition, immunocytochemical studies have shown an isolated defect of subunit VIIa, which is 1 of the only 2 tissue-specific subunits of human COX. In muscle biopsies from patients with Kearns-Sayre syndrome, a multisystem disorder characterized by deletions of the mitochondrial DNA (mtDNA), the activities of all mitochondrial enzymes containing mtDNA-encoded subunits are decreased. The results of Northern analysis, in situ hybridization, and immunocytochemistry in muscle, and of mitochondrial protein synthesis in cultured fibroblasts suggest that partially deleted mtDNAs are transcribed but not translated, probably due to lack of indispensable tRNAs.     

Manifestations of insulin-dependent diabetes mellitus in the periodontium of young Brazilian patients

The periodontal condition of patients with insulin-dependent diabetes mellitus was evaluated in terms of plaque, gingival indices, pocket depth, and alveolar bone loss. Thirty male and female diabetic patients aged 5 to 18 years were compared with 30 non-diabetic subjects and correlated with sex and age. Statistical analyses of the data showed that the mean plaque index was significantly higher (P less than 0.01) among the diabetic patients (1.23) than among the control subjects (0.81). The plaque index was significantly higher (P less than 0.01) among diabetic females (1.34) than among diabetic males (1.10), whereas no sex differences were observed in the control group. The arithmetic means obtained for gingival index were statistically higher (P less than 0.01) for the diabetics (0.58) when compared with the controls (0.15), but no significant differences were obtained when the values were correlated with sex and age. Pocket depth did not differ statistically between groups. When pocket depth was correlated with sex, a statistically significant difference (P less than 0.05) was observed only for the palatal region, with a depth of 2.1 mm in female patients and 1.92 mm in male patients. When pocket depth was correlated with age, a positive correlation (P less than 0.01) was detected in the diabetic group for all regions investigated, whereas the correlation was not significant in the control group. Mean alveolar bone loss was higher in the anterior upper (1.94 mm) and anterior lower (1.87 mm) regions of the diabetic group when compared to the controls (1.52 and 1.37 mm respectively), the difference being significant at the 5% level of probability.(ABSTRACT TRUNCATED AT 250 WORDS)     

医疗纠纷尸检86例法医学分析

目的：以法医学观点分析讨论医疗纠纷尸检的意义和重要性。方法：从本系1993年－2001年9月尸检资料中选出涉及医疗纠纷的86例资料，经驻表格逐一登记，分类整理，最后进行分析。结果：医疗纠纷的发生率逐年增多，且多集中于儿科（20例，23.2%)、产科（19例，22.1%)、内科（16例，18.6%)、诊所（10例，11.6%)、外科（9例，10.5%)等。医疗纠纷多与院内猝死、难以避免的并发症死亡、临床诊断不清、误诊、误治及医务人员态度不好等有关。结论：医疗纠纷的发生与许多因素有关，法医受理医疗纠纷尸检在程序上有利于取得社会公信，并有利于纠纷的最终解决。     

Mitochondrial myopathy of childhood associated with depletion of mitochondrial DNA.

We have studied five children with mitochondrial myopathy manifesting within or soon after the first year of life. Muscle biopsies showed ragged-red fibers and decreased respiratory chain activity. All five patients had a severe decrease (2 to 34% of normal) in the amount of muscle mitochondrial DNA (mtDNA). The depletion of mtDNA correlated with absence of mtDNA-encoded translation products and with loss of cytochrome c oxidase enzyme activity in individual muscle fibers. This mitochondrial myopathy of childhood illustrates one phenotypic expression of a novel pathogenetic mechanism in mitochondrial diseases, the specific depletion of mtDNA in affected tissues.     

重症肌无力患者IgG脑室内注射对大鼠EEG及BAEP的影响

目的 观察重症肌无力(myasthenia gravis，MG)患者IgG(AChRAb)经大鼠脑室内注入对其脑电图(electroencephalography，EEG)及脑干听觉诱发电位(brain stem auditory evoked potential，BAEP)的影响，并探讨AChRAb影响大鼠中枢神经系统(CNS)的机制。方法将从确诊的、AChRAb阳性的MG患者血清中提纯的IgG(AChRAb)，注射到实验组大鼠侧脑室，对照组大鼠则注射健康人IgG，观察大鼠行为学、BAEP、EEG改变。结果实验组大鼠术后出现类似于实验性自身免疫性MG的行为学改变，部分大鼠出现癫痫发作BAEP峰间潜伏期(IPLs)延长EEG异常，即δ、θ增多与痫性波发放增加。结论 MGAChRAb可致大鼠CNS损害，AChRAb与大鼠CNS神经元型乙酰胆碱受体结合，可能是其病理生理机制。     

切开复位内固定治疗跟骨关节内骨折

跟骨骨折多为高处坠落伤所致,损伤机制为偏心负荷引起的剪切、压缩骨折,多累及距下关节面,属关节内骨折。2000-2004年我科采用切开复位内固定治疗跟骨关节内骨折并获得随访20例,取得满意效果。1临床资料本组20例,男15例,女5例;年龄20~60岁。均为闭合性骨折。术前均摄跟骨正侧位     

新生儿医院感染情况分析及对策

新生儿由于其特殊的易感因素,医院感染发生率较高,有的甚至造成暴发流行。为了探讨其医院感染的相关因素及预防措施,我们回顾性分析了245例新生儿病历,其中发生医院感染38例,现报道如下。资料与方法1.一般资料。为我院2004年1-12月住院新生儿共245例,其中男156例,女89例;年龄15     

饲料中添加钴、维生素B12对羔羊生长的影响

选用产期接近的3月龄小尾寒羊30只,随机分为二组(试验Ⅰ、试验Ⅱ),每组15只。试验Ⅰ饲喂本场加工的羔羊精饲料,试验Ⅱ饲喂本场加工的羔羊精饲料基础上,每公斤饲料中分别添加钴0.4mg和维生素B120.30mg,试验结果表明:试验Ⅰ与试验Ⅱ日增重相比差异极显著(P<0.01)。