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991.
992.
993.
Emer Shanley Declan Patton Pinar Avsar Tom O'Connor Linda Nugent Zena Moore 《International wound journal》2022,19(4):754
Pressure ulcers (PUs) have a profound impact on individuals, with studies demonstrating that compared with similarly aged persons, those living with a PU have a significantly lower quality of life. The aim of this study was to explore the impact of the Shanley Pressure Ulcer Prevention Programme (SPUPP) on older persons'' knowledge of, and attitudes and behaviours towards, PU prevention. This was a multi‐centre, open‐label, randomised controlled trial. The population of interest was older persons living in the community who attended either a day care centre or a retirement group and were deemed to be at risk of PUs due to reduced mobility. Stratified random sampling was used to randomise based on days of attendance at day care centre/retirement group. Pretest and post‐test were applied to the intervention and control groups. The SPUPP is a multimedia programme delivered using electronic media, hard copy materials, activities, and patient diaries and addresses the key tenets of PU prevention as described by the SKIN bundle. The programme contains five separate sessions delivered over 5 weeks. The impact of the SPUPP was assessed using the patient knowledge of and attitude and behaviour towards PU prevention instrument (KPUP). A total of 64 persons, 32 in each group, took part in the study. Of these, 75% (n = 48) were female, with a mean age of 81.9 years (SD: 5.56 years). Further, 68.8% (n = 44) were either overweight or obese and 40.6% (n = 26) were usually incontinent of urine. There were no differences between the intervention and control groups in mean scores during the pretest stage. However, at post‐test, the mean scores for the intervention group were higher than the control group, 16.87 (SD: 1.88) versus 12.41 (SD: 3.21), respectively. For the post‐test stage, mean differences between the two groups in favour of the intervention group (∆ = 4.46) were statistically significant, as t = 6.76, P = .0001, and equal variances were not assumed. The SPUPP impacted positively on knowledge scores of the participants and positively influenced attitudes and behaviours towards PU prevention. Thus, this research provides information regarding the potential to enhance patient involvement in PU prevention. 相似文献
994.
Sherman Fong John J. Miller Terry L. Moore Constantine D. Tsoukas John H. Vaughan Dennis A. Carson 《Arthritis \u0026amp; Rheumatology》1982,25(8):959-965
The relative frequencies of IgM antilgG autoantibody (rheumatoid factor) producing cells induced by the polyclonal B cell activator Epstein-Barr virus were measured in peripheral blood lymphocyte cultures of normal children and patients with juvenile rheumatoid arthritis. The frequencies of rheumatoid factor precursor B cells in normal children were lower than adults, but higher than neonates. The frequency increased with the age of the donor. In seronegative children with the systemic-onset or pauclarticular-onset types of juvenile rheumatoid arthritis, the number of IgM antiIgG inducible B cells was not significantly different (P>0.05) from age-matched controls. Patients with seropositive juvenile rheumatoid arthritis or seropositive adult rheumatoid arthritis had significantly higher IgM antiIgG precursor cell frequencies than age-matched normal subjects (P<0.01 and P<0.02, respectively). In contrast, the patients with seronegative polyarticular-onset juvenile rheumatoid arthritis had an average precursor frequency significantly lower than normal age-matched controls (P<0.05), analogous to results previously noted in adult seronegative rheumatoid arthritis. Thus, both children and adults with seronegative polyarticular rheumatoid arthritis had a deficiency in B cells that produce IgM antiIgG and that are induced by Epstein-Barr virus. This distinguished them from seropositive juvenile rheumatoid arthritis and rheumatoid arthritis patients, normal subjects, and patients with the pauciarticular-onset and systemic-onset types of seronegative juvenile rheumatoid arthritis. 相似文献
995.
Michael Hughes Tonia Moore Joanne Manning Jack Wilkinson Stuart Watson Prawin Samraj Graham Dinsdale Chris Roberts Ariane Herrick Andrea Murray 《Lancet》2017
Background
Locally acting, well-tolerated treatments for digital ulcers in patients with systemic sclerosis are needed. We aimed to investigate the safety, feasibility, and tolerability of a novel light treatment, and to tentatively assess treatment efficacy.Methods
Light treatment with an in-house built phototherapy lamp was administered twice per week for 3 weeks, with follow-up at 4 and 8 weeks. Adverse events were documented. Data on patient opinion about the time to deliver, feasibility (“not feasible”, “indifferent”, “feasible”), and pain (visual analogue scale [VAS], 0–100) were collected. Patient and clinician assessment of severity of digital ulcers (VAS, 0–100) was documented. An independent assessor graded change in appearance of digital ulcers from photographs (?2 to +2). Laser doppler imaging (to assess perfusion) was performed before and after treatment. A linear mixed-effects model was used to assess change in digital ulcer status. This study is registered with ClinicalTrials.gov, number NCT02472743.Findings
Eight patients with 14 digital ulcers were recruited. 46 light treatments were administered, with no adverse events. All patients believed that light treatment was “feasible” and “took just the right amount of time”, with a low associated mean pain VAS of 1·6 (SD 5·2). Severity of digital ulcers as judged by patients and clinicians improved during the study (mean change in VAS ?7·1 and ?5·2, respectively; both p≤0·001). According to independent assessment, mean change in appearance of digital ulcers per week was 0·14 (95% CI 0·0–0·3) (p=0·01). There was a significant increase in the relative (compared with baseline) mean perfusion after (compared with before) light treatment, in particular at the centre of the digital ulcer (0·32, 95% CI 0·13–0·52; p=0·0013).Interpretation
Light treatment for digital ulcers in systemic sclerosis is safe, feasible, and well tolerated. There was an early tentative suggestion of treatment efficacy. Future research is warranted to develop light-based treatment as a locally acting therapy for digital ulcers in patients with systemic sclerosis.Funding
Arthritis Research UK. 相似文献996.
997.
Joy V. Nolte Fong Derek Miketinas Linda W. Moore Duc T. Nguyen Edward A. Graviss Nadim Ajami Mindy A. Patterson 《Nutrients》2022,14(2)
Individual glycemic responses following dietary intake result from complex physiological processes, and can be influenced by physical properties of foods, such as increased resistant starch (RS) from starch retrogradation. Predictive equations are needed to provide personalized dietary recommendations to reduce chronic disease development. Therefore, a precision nutrition model predicting the postprandial glucose response (PPGR) in overweight women following the consumption of potatoes was formulated. Thirty overweight women participated in this randomized crossover trial. Participants consumed 250 g of hot (9.2 g RS) or cold (13.7 g RS) potatoes on two separate occasions. Baseline characteristics included demographics, 10-day dietary records, body composition, and the relative abundance (RA) and α-diversity of gut microbiota. Elastic net regression using 5-fold cross-validation predicted PPGR after potato intake. Most participants (70%) had a favorable PPGR to the cold potato. The model explained 32.2% of the variance in PPGR with the equation: 547.65 × (0 [if cold, high-RS potato], ×1, if hot, low-RS potato]) + (BMI [kg/m2] × 40.66)—(insoluble fiber [g] × 49.35) + (Bacteroides [RA] × 8.69)—(Faecalibacterium [RA] × 73.49)—(Parabacteroides [RA] × 42.08) + (α-diversity × 110.87) + 292.52. This model improves the understanding of baseline characteristics that explain interpersonal variation in PPGR following potato intake and offers a tool to optimize dietary recommendations for a commonly consumed food. 相似文献
998.
Ricardo U. Sorensen Hugo Hidalgo Cleveland Moore Lily E. Leiva 《Pediatric pulmonology》1996,22(3):167-173
IgG antibodies against pneumococcal polysaccharides are found predominantly within IgG subclass 2. We wished to evaluate retrospectively IgG subclasses and post-immunization pneumococcal antibody titers in children with recurrent respiratory infections. We examined total immunoglobulin levels and IgG subclasses, as well as pneumococcal antibody titers against serotypes 3, 7F, 9N, and 14 present 4–6 weeks after pneumococcal immunization in 56 children 2–18 years old. Titers >200 ng Ab N/ml to any of the 4 serotypes tested were arbitrarily considered protective. Four patients did not have protective antibody levels against any of the 4 serotypes tested following vaccination. Of those, 3 had normal IgG subclass levels and 1 had an IgG2 subclass deficiency. Of 3 additional patients with IgG2 deficiency, 2 had protective antibody levels to only 1 serotype and 1 had protective antibody levels to 2 serotypes. Furthermore, in 2 patients with undetectable IgG2 at the time of immunization, the response was only transient. We conclude that patients with IgG2 deficiency may not develop protective antibody levels to all pneumococcal serotypes and that some may have deficient memory for IgG anti-pneumococcal polysaccharide antibodies. Pediatr Pulmonol. 1996; 22:167–173. © 1996 Wiley-Liss, Inc. 相似文献
999.
Julie Olszewski Joseph McDonnell Karla Stevens Denise Visco Vernon Moore 《Arthritis \u0026amp; Rheumatology》1996,39(7):1234-1237
Objective. To quantify the matrix metalloproteinase–induced neoepitope F(M/V)DIPEN (Phe–[Met/Vall]-Asp–Jle–Pro–Glu–Asn341) in guinea pig and rabbit cartilage during aging. Methods. Cartilage was taken from the stifle joint, nasal septum, and xiphoid process in guinea pigs and rabbits at selected ages. The cartilage was then extracted and evaluated for F(M/V)DIPEN levels by radioimmunoassay. Results. In the 3 tissues studied, there were major increases in F(M/V)DIPEN levels during skeletal maturation and aging in both the guinea pig and rabbit cartilage. Except for spontaneous osteoarthritis that develops in guinea pigs with aging, increases in the neoepitope were not correlated with arthritis pathology. Conclusion. Increases in the level of F(M/V)-DIPEN in cartilage occur as a result of skeletal maturation and aging. This physiologic accumulation of F(M/V)DIPEN in cartilage should be considered when using the neoepitope as a disease marker in arthritis. 相似文献
1000.
Hideo Ohkita Akira Tsuchida Masahide Yamamoto James A. Moore Donald R. Gamble 《Macromolecular chemistry and physics.》1996,197(8):2493-2499
The photocleavage reaction of dimer model compounds of photosensitive polyimides having cyclobutane rings in the main chain was studied. Efficient photocleavage was observed for the dimer models (CBAM2, CBAM4, and CBPM2) which had an electron-donating aromatic substituent at the electron-accepting imide group. On the other hand, the cleavage quantum yield was nearly zero for a dimer (CBCM2) which had a cyclohexane substituent instead of the aromatic ring. Solvent polarity effects on the cleavage quantum yield revealed that these dimers gave the largest photocleavage efficiency in medium-polar solvents. The transient absorption band of the excited triplet of CBPM2 was effectively quenched by oxygen, whereas no oxygen quenching was observed for the cleavage quantum yield. This leads to the conclusion that the cyclobutane ring in the polyimide is photocleaved via the excited singlet intramolecular CT state. 相似文献