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Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease in
which most patients die of respiratory failure. Although volume-targeted non-invasive
bilevel positive airway pressure (BPAP) ventilation has been studied in patients with
chronic respiratory failure of various etiologies, its use in ALS has not been
reported. We present the case of a 66-year-old woman with ALS and respiratory failure
treated with volume-targeted BPAP ventilation for 15 weeks. Weekly data downloads
showed that disease progression was associated with increased respiratory muscle
weakness, decreased spontaneous breathing, and increased use of non-invasive positive
pressure ventilation, whereas tidal volume and minute ventilation remained relatively
constant. 相似文献
54.
José Sanz-Santos Mireia Martínez-Palau Àngels Jaen Ramón Rami-Porta Bienvenido Barreiro Sergi Call Carme Obiols José Manuel González José Ángel De Marcos Montserrat Ysamat Lydia Canales Mireia Serra Josep Belda 《The Annals of thoracic surgery》2021,111(4):1190-1197
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55.
Carme Ferré-Grau María Sevilla-Casado Montserrat Boqué-Cavallé M. Rosa Aparicio-Casals Amparo Valdivieso-López Mar Lleixá-Fortuño 《Atencion primaria / Sociedad Espa?ola de Medicina de Familia y Comunitaria》2012,44(12):695-701
ObjectiveTo determine the effectiveness of Problem Solving Technique in reducing anxiety and depression, and increased perceived well-being in women family caregivers of chronic patients.DesignA clinical trialField of studyHealth centres in Tarragona, Spain, during 2007-2011.ParticipantsA sample 122 caregivers of patients in home care programs that met the inclusion criteria, were assigned to intervention or control group according to a simple random process.InterventionsIn the experimental group, the nurses applied the Problem Solving Technique to the caregiver according to a four-session protocol. The nurses provided the usual care to the caregivers In the control group. One month after intervention, the dependent vriables were measured again in both groups.Principal measurementThe dependent variables of anxiety and depression were measured using the Goldberg scale, and the emotional well-being variable by the scale of emotional health of the primary caregiver.ResultsA statistically significant improvement was detected in the anxiety and depression symptoms, as well as the perceived well-being in the intervention group compared to the control group.ConclusionsImplementation of the Problem Solving Technique is a useful therapeutic tool for reducing symptoms of distress in family caregivers of chronic patients. 相似文献
56.
Susanne Halken Desiree Larenas‐Linnemann Graham Roberts Moises A. Calderón Elisabeth Angier Oliver Pfaar Dermot Ryan Ioana Agache Ignacio J. Ansotegui Stefania Arasi George Du Toit Montserrat Fernandez‐Rivas Roy Geerth van Wijk Marek Jutel Jörg Kleine‐Tebbe Susanne Lau Paolo M. Matricardi Giovanni B. Pajno Nikolaos G. Papadopoulos Martin Penagos Alexandra F. Santos Gunter J. Sturm Frans Timmermans R. van Ree Eva‐Maria Varga Ulrich Wahn Maria Kristiansen Sangeeta Dhami Aziz Sheikh Antonella Muraro 《Pediatric allergy and immunology》2017,28(8):728-745
Allergic diseases are common and frequently coexist. Allergen immunotherapy (AIT) is a disease‐modifying treatment for IgE‐mediated allergic disease with effects beyond cessation of AIT that may include important preventive effects. The European Academy of Allergy and Clinical Immunology (EAACI) has developed a clinical practice guideline to provide evidence‐based recommendations for AIT for the prevention of (i) development of allergic comorbidities in those with established allergic diseases, (ii) development of first allergic condition, and (iii) allergic sensitization. This guideline has been developed using the Appraisal of Guidelines for Research & Evaluation (AGREE II) framework, which involved a multidisciplinary expert working group, a systematic review of the underpinning evidence, and external peer‐review of draft recommendations. Our key recommendation is that a 3‐year course of subcutaneous or sublingual AIT can be recommended for children and adolescents with moderate‐to‐severe allergic rhinitis (AR) triggered by grass/birch pollen allergy to prevent asthma for up to 2 years post‐AIT in addition to its sustained effect on AR symptoms and medication. Some trial data even suggest a preventive effect on asthma symptoms and medication more than 2 years post‐AIT. We need more evidence concerning AIT for prevention in individuals with AR triggered by house dust mites or other allergens and for the prevention of allergic sensitization, the first allergic disease, or for the prevention of allergic comorbidities in those with other allergic conditions. Evidence for the preventive potential of AIT as disease‐modifying treatment exists but there is an urgent need for more high‐quality clinical trials. 相似文献
57.
Impact of anthropometric features on the applicability and accuracy of FibroScan® (M and XL) in overweight/obese patients
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58.
Luz Balsalobre Montserrat Ortega Adela G. de la Campa 《Antimicrobial agents and chemotherapy》2013,57(1):254-260
Fourteen fluoroquinolone-resistant streptococcal isolates with recombinant DNA topoisomerase genes, preliminarily identified as pneumococci, were further characterized using phenotypic and genotypic approaches. Phenotypic tests classified them as atypical pneumococci. Phylogenetic relationships were analyzed by using the sequences of seven housekeeping alleles from these isolates and from isolates of Streptococcus pneumoniae, Streptococcus mitis, Streptococcus oralis, and Streptococcus pseudopneumoniae. Four isolates grouped with S. pneumoniae, seven grouped with S. pseudopneumoniae, and three grouped with S. mitis. These results generally agreed with those obtained with an optochin susceptibility test and with the organization of the atp operon chromosomal region, encoding the FoF1 H+-ATPase (the target of optochin). All seven isolates grouping with S. pseudopneumoniae share the same spr1368-atpC-atpA gene order; all four grouping with S. pneumoniae share the spr1368-IS1239-atpC-atpA order, and two out of the three grouping with S. mitis share the spr1284-atpC-atpA order. In addition, evidence for recombination within the seven housekeeping alleles of the S. pseudopneumoniae population was provided by several methods: the index of association (0.4598, P < 0.001), the pairwise homoplasy index, and the split-decomposition method. This study confirms the existence of pneumococci among the alpha-hemolytic streptococci with DNA topoisomerase genes showing a mosaic structure and reveals a close relationship between atypical pneumococci and S. pseudopneumoniae. 相似文献
59.