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Votteler T. P. Lipsky K. 《世界核心医学期刊文摘》2006,2(2):31-31
背景/目的:从1978-2000年,有10对联体双胞胎成功接受了手术分离,结果14人存活。其中6对是因为他们的联体同胞死亡或濒临死亡而接受紧急分离手术。剩余的4对,每对至少一个同胞接受至少一次的急诊手术后,才接受联体分离手术。方法:对这一独特的队列进行包含6个项目的问卷调查。问题的设计是开放式的,为父母/家庭提供有关信息的最大机会。对每个家庭就相同的问题也进行了当面的问卷调查。医师询问了与身体健康和疾病相关的一些问题。而社会工作询问了与发育、教育、社会心理和家庭功能相关的问题。结果:前面提及的14人存活的双胞胎中,4人大学毕业,1人于1981年完成中学学业,剩余9人正在上学。14人在最初的手术后,还需要接受再次手术,尤其是需要矫正泌尿系统、畸形、神经外科和小儿外科的问题。结论:通过超声检查对联体双胎进行宫内诊断,可以使医师和胎儿父母在孕早期决定在终止妊娠时是进行双胎分离还是保全其中一个。这些病例报道通过描述14例手术存活的长期体格检查和心理学检查结果,为医师和父母在关键时刻做出决定提供了另外有助的依据。 相似文献
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Hasan Sunar Gülara Hüseyinova Suat Canbaz Umit Halici Enver Duran 《Blood coagulation & fibrinolysis》2003,14(8):703-706
Low molecular weight heparins are widely used in the prophylaxis and treatment of thrombotic disorders. The effect of low molecular weight heparins on coagulation was examined ultrastructurally in an animal model. A test and a control group was formed, each consisting of five rabbits. Nadroparine (225 Institute of Chaoy Unit/kg twice daily) was applied to the test group for 10 days. The control group received 1 ml saline solution subcutaneously. Blood and vascular tissue samples collected at the end of the 10th day were evaluated under a JEM 100 B electron microscope. Platelet degranulation and agglutination was observed in the control group. Fibrin materials were detected in the cytoplasms and surroundings of degranulated platelets. Erythrocyte accumulation was remarkable on the vascular endothelium with intact coagulation periods. In the test group, outer membranes of platelets, hyalomere, and granular structures in the granulomeres were detected to be nearly intact. There were rare erythrocytes in the large vascular lumens. The aggregation phase had occurred but no agglutination was detected. Nadroparine seems to preserve consistency of lipoprotein membranes of platelets and granular structures containing enzymes, which contribute to the coagulation mechanisms. 相似文献
55.
S. Spinty H. Rogozinski G. T. Lealman J. E. Wraith 《Journal of inherited metabolic disease》2003,25(8):697-698
Summary: A female patient with isovaleric acidaemia had a successful outcome from pregnancy. 相似文献
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Bethe A Scalettar 《The Neuroscientist》2006,12(2):164-176
Neurons and related cell types often contain two major classes of neurosecretory vesicles, synaptic vesicles (SVs) and dense-core granules (DCGs), which store and release distinct cargo. SVs store and release classic neurotransmitters, which facilitate propagation of action potentials across the synaptic cleft, whereas DCGs transport, store, and release hormones, proteins, and neuropeptides, which facilitate neuronal survival, synaptic transmission, and learning. Over the past few years, there has been a major surge in our understanding of many of the key molecular mechanisms underlying cargo release from SVs and DCGs. This surge has been driven largely by the use of fluorescence microscopy (especially total internal reflection fluorescence microscopy) to visualize SVs or DCGs in living cells. This review highlights some of the recent insights into cargo release from neurosecretory vesicles provided by fluorescence microscopy, with emphasis on DCGs. 相似文献
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Abnormal spinal interactions from hand afferents to forearm muscles in writer's cramp. 总被引:1,自引:0,他引:1
G Louren?o J-P Bleton C Iglesias M Vidailhet V Marchand-Pauvert 《Clinical neurophysiology》2007,118(10):2215-2226
OBJECTIVE: Spinal reflexes from hand to wrist muscles were investigated in writer's cramp. METHODS: Stimulus-triggered rectified EMG averages after ulnar nerve and cutaneous stimulation, in wrist flexors and extensors during tonic contraction, were compared in 18 controls and 19 patients. RESULTS: On the patient dystonic side, ulnar-induced EMG suppression was decreased in wrist extensors, and facilitation in wrist flexors modified dependent on the dystonic wrist posture during writing. No change was found on the patient non-dystonic side. Cutaneous stimulation increased wrist flexor EMG on both sides of the patients with normal wrist posture during writing, but had no effect in controls and patients with abnormal wrist posture. CONCLUSIONS: Comparison between cutaneous and mixed nerve stimuli suggests that spindle afferents from intrinsic hand muscles may mediate patients' ulnar-induced EMG modulations. Abnormal proprioceptive control was only observed on dystonic side, while bilateral unusual cutaneous control was found in patients. Changes in spinal transmission were partly related to the dystonic wrist posture, suggesting that systems involved in sensory processing can be differentially altered in writer's cramp. SIGNIFICANCE: Changes in spinal transmission, probably related to peripheral and/or cortical inputs, might either take part in primary or adaptive mechanisms underlying writer's cramp. 相似文献