全文获取类型
收费全文 | 1214篇 |
免费 | 56篇 |
国内免费 | 147篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 60篇 |
妇产科学 | 11篇 |
基础医学 | 93篇 |
口腔科学 | 18篇 |
临床医学 | 174篇 |
内科学 | 304篇 |
皮肤病学 | 29篇 |
神经病学 | 38篇 |
特种医学 | 313篇 |
外科学 | 76篇 |
综合类 | 26篇 |
预防医学 | 83篇 |
眼科学 | 13篇 |
药学 | 117篇 |
1篇 | |
中国医学 | 2篇 |
肿瘤学 | 58篇 |
出版年
2022年 | 8篇 |
2021年 | 14篇 |
2020年 | 6篇 |
2019年 | 12篇 |
2018年 | 17篇 |
2017年 | 8篇 |
2016年 | 16篇 |
2015年 | 16篇 |
2014年 | 18篇 |
2013年 | 39篇 |
2012年 | 23篇 |
2011年 | 26篇 |
2010年 | 36篇 |
2009年 | 49篇 |
2008年 | 39篇 |
2007年 | 118篇 |
2006年 | 34篇 |
2005年 | 31篇 |
2004年 | 22篇 |
2003年 | 11篇 |
2002年 | 19篇 |
2001年 | 18篇 |
2000年 | 16篇 |
1999年 | 17篇 |
1998年 | 78篇 |
1997年 | 78篇 |
1996年 | 71篇 |
1995年 | 61篇 |
1994年 | 42篇 |
1993年 | 53篇 |
1992年 | 11篇 |
1991年 | 23篇 |
1990年 | 19篇 |
1989年 | 56篇 |
1988年 | 35篇 |
1987年 | 37篇 |
1986年 | 30篇 |
1985年 | 27篇 |
1984年 | 24篇 |
1983年 | 13篇 |
1982年 | 28篇 |
1981年 | 16篇 |
1980年 | 15篇 |
1979年 | 13篇 |
1978年 | 4篇 |
1977年 | 17篇 |
1976年 | 28篇 |
1975年 | 14篇 |
1968年 | 2篇 |
1966年 | 2篇 |
排序方式: 共有1417条查询结果,搜索用时 16 毫秒
51.
Fadi M. Toum Ahmed Moh. Mah. Fadelallah Eljack Mohamed Abdulkarim Hiba Faroug Alamin Mohammed 《Clinical Case Reports》2022,10(3)
(HHT) is a rare disorder affecting the skin and body''s internal organs with a tendency for bleeding. We report a case of Sudanese 42‐year‐old with family history of HHT presented with recurrent epistaxis and telangiectasias. 相似文献
52.
Claire Rutherford Winston Martin Moh Salame Martin Carrier Erik ngg rd Gordon Ferns 《Atherosclerosis》1997,130(1-2):45-51
Thirty percent of patients undergoing percutaneous transluminal coronary angioplasty develop recurrent disease within a year. This is usually due to the rapid accumulation of intimal smooth muscle cells and extracellular matrix, which causes luminal narrowing, and is probably orchestrated by several mitogenic and chemotactic factors, of which platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) appear to be particularly important. We have investigated the effects of administering a combination of neutralizing antibodies directed against PDGF-BB and bFGF on neo-intima development following balloon catheter injury in the rat carotid artery. Purified sheep anti-PDGF-BB and anti-bFGF immunoglobulins (IgGs) were administered singly and in combination prior to mechanical injury and daily until sacrifice, 8 days later. Plasma titres of exogenous anti-PDGF-BB and anti-bFGF were maintained at levels 10–20-fold higher than those required to neutralise the mitogenic and chemotactic effects of 20 ng/ml of PDGF-BB, or 10 ng/ml bFGF in vitro. Used singly, anti-PDGF IgG treatment was associated with a 47% reduction in intimal thickness and a 59% reduction in intimal:medial area ratio; anti-bFGF IgG administration caused a 53% reduction in intimal thickness, and a 50% reduction in intimal:medial area ratio. Treatment with a combination of these antibodies resulted in a 83.8% reduction in intimal thickness (P<0.05), and a 91% reduction in intimal:medial area ratio (P<0.01). The latter treatment was also associated with a significantly higher intimal cell density (14.2±1.6×103 nuclei/mm2) compared to animals receiving non-immune IgG (7.8±0.8×103 nuclei/mm2; P<0.025), although intimal and medial cell proliferation indices were not significantly different between the groups (P>0.05). Our results suggest that in this particular model, PDGF-BB and bFGF are the major factors controlling neointimal hyperplasia, and that these growth factors are operating principally via an effect on smooth muscle cell migration and extracellular matrix protein accumulation. 相似文献
53.
54.
55.
56.
57.
Salah Eldin M. E. Hassan Mohamed Alamin Ahmed Sabir Taha Hussein Abdallah Elamin Elsheikh Moh. Mah. Fadel Alla Eljack Mazin SalahEldien Hassan Haroun Khabab Abbasher Hussien Mohamed Ahmed Mohammed Eltahier Abdalla Omer Ghassan Elfatih Mustafa 《Clinical Case Reports》2022,10(1)
A 3‐year‐old child presented with recurrent chest pain for 3 months, echocardiography showed a thorn inside the left ventricle, the patient was diagnosed with foreign body complicated with infective endocarditis and received proper treatment, and operation was performed after inflammatory reaction subsided. 相似文献
58.
59.
Genomic Understanding Reveals the Important Role of FGFR2 as Paeoniflorin Target for Circumventing Breast Cancer Resistance to Tamoxifen
下载免费PDF全文
![点击此处可从《Asian Pacific journal of cancer prevention》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Moh Arikus WibowoEri Prasetyo NugrohoAdam Hermawan 《Asian Pacific journal of cancer prevention》2021,22(12):3949-3958
Objectives: Paeoniflorin (PF), a compound found in Paeonia lactiflora and Paeonia suffruticosa, has anticancer potential, particularly in inhibiting migration and invasion, the resistant cancer cells hallmarks. To date, the mechanism of overcoming tamoxifen resistance in breast cancer is not yet elucidated. This research aims to explore the potential target of PF as a co-treatment for circumventing breast cancer resistance to tamoxifen with a genomic understanding-bioinformatics. Methods: Microarray data originating from GSE67916 and GSE85871 in the NCBI GEO database was analyzed to obtain differentially expressed genes (DEGs). Further analyses were performed on DEGs using the DAVID v6.8, STRING-DB v11.0, the Cytoscape, and cBioportal. Gene expression analysis validation in breast cancer cells and tamoxifen-resistant breast cancer cells was accomplished using GEPIA and ONCOMINE databases. Survival rate analysis of selected genes was conducted using Kaplan–Meier. Results: We obtained 175 DEGs from the two samples (tamoxifen-resistant and paeoniflorin-treated). DEG involves in 70 biological processes, 26 cellular components, and 18 molecular functions, and three pathways relevant to breast cancer. The PPI network analysis and hub genes selection obtained 10 genes with the highest degree scores. Genetic changes for selected genes, including IFNB1, CDK6, FGFR2, OAS1, BCL2, and STAT2 were found from 0.5% to 7% of the case population per patient case. Additional analysis using cBioportal revealed FGFR signaling pathway through Ras is important for the PF mechanism in circumventing breast cancer resistance to tamoxifen. ONCOMINE and GEPIA analysis emphasized the importance of selected genes in the tamoxifen-resistance mechanism. Conclusion: PF has potential to be used as a co-treatment for circumventing breast cancer resistance to tamoxifen by targeting FGFR2 signaling, but further validation is needed. 相似文献
60.
四种中成药对气血双虚模型小鼠血象及免疫水平的影响 总被引:1,自引:0,他引:1
目的:为艾滋病抗病毒疗法所致的骨髓不良反应筛选疗效确切的中成药,观察分析参芪颗粒、复方阿胶浆、贞芪扶正颗粒、复方皂矾丸四种中成药对放血和注射环磷酰胺联合复制的气血双虚模型小鼠血象及免疫水平的影响。方法:实验于2005-08/09在河南中医学院药理实验室完成。①参芪颗粒(江西山高制药有限公司生产,批号040702);复方阿胶浆(山东东阿阿胶股份有限公司生产,批号050446);贞芪扶正颗粒(甘肃扶正药业科技股份有限公司生产,批号040803);复方皂矾丸(陕西郝其军制药有限责任公司生产,批号041014);当归补血口服液(郑州市协和制药厂生产,批号041122);环磷酰胺(上海华联制药有限公司生产,批号050101)。②选取清洁级昆明种小鼠150只,随机数字表法分为15组,10只/组:1~3组分别灌服参芪颗粒混悬液3,2,1g/kg;4~6组分别灌服复方阿胶浆30,20,10mL/kg;7~9组分别灌服贞芪扶正颗粒混悬液15,10,5g/kg;10~12组分别灌服复方皂矾丸混悬液2.4,1.6,0.8g/kg;第13组灌服当归补血口服液10g/kg;剩余2组为空白对照组和模型对照组,分别给于同体积生理盐水10g/kg。各组给药1次/d,连续给药10d。③除空白对照组外,其他各组从给药第1天开始建立气血双虚模型。每只鼠尾部放血0.25mL/10g,然后分别于第2,4,6,8天腹腔注射环磷酰胺80,40,40,40mg/kg。空白对照组同时间点仅腹腔注射等体积生理盐水。末次注射环磷酰胺后2h,眼眶取血,一部分用于血象测定,另一部分离心取血清,测定血细胞比容及血清中巨噬细胞集落刺激因子水平;解剖取胸腺和脾脏,检测胸腺皮质厚度、胸腺淋巴细胞数、脾小结大小、脾脏淋巴细胞数病理学指标的变化。结果:150只小鼠全部进入结果分析,放血和注射环磷酰胺并用可成功建立小鼠气血双虚模型。①与模型对照组比较,参芪颗粒3g/kg组、贞芪扶正颗粒10,5g/kg组、复方皂矾丸1.6g/kg组均可升高气血双虚模型小鼠白细胞水平(t=2.18~2.74,P<0.05),贞芪扶正颗粒15g/kg组作用更为显著(t=2.98,P<0.01);参芪颗粒1g/kg组、复方阿胶浆20mL/kg组、贞芪扶正颗粒15,10g/kg组均可升高红细胞水平(t=2.44~2.69,P<0.05),复方阿胶浆30mL/kg组、贞芪扶正颗粒5g/kg组、复方皂矾丸2.4,1.6g/kg组作用更为显著(t=2.91~3.66,P<0.01);当归补血口服液组、复方阿胶浆20mL/kg组、参芪颗粒3,1g/kg组、贞芪扶正颗粒15,10,5g/kg组均可升高血红蛋白水平(t=2.27~2.85,P<0.05),复方阿胶浆30mL/kg组、复方皂矾丸2.4,1.6g/kg组作用更为显著(t=3.07~4.04,P<0.01);当归补血口服液组、参芪颗粒3,2g/kg组均可升高血小板水平(t=2.20~2.41,P<0.05)。②与模型对照组比较,参芪颗粒2g/kg组、贞芪扶正颗粒5g/kg组均可升高气血双虚模型小鼠血细胞比容(t=2.01~2.62,P<0.05),参芪颗粒1g/kg组、复方阿胶浆30,20,10mL/kg组、贞芪扶正颗粒15,10,5g/kg组、复方皂矾丸2.4,1.6,0.8g/kg组作用更为显著(t=3.18~4.36,P<0.01);参芪颗粒2g/kg组、复方阿胶浆30,20,10mL/kg组、贞芪扶正颗粒15,10,5g/kg组、复方皂矾丸2.4,1.6g/kg组均可显著升高巨噬细胞集落刺激因子水平(t=3.60~6.80,P<0.01)。③与模型对照组比较,当归补血口服液组、参芪颗粒3,2,1g/kg组、复方阿胶浆30,20,10mL/kg组、贞芪扶正颗粒15,10,5g/kg组、复方皂矾丸2.4,1.6,0.8g/kg组均可显著增加气血双虚模型小鼠胸腺皮质厚度(t=3.71~9.34,P<0.01),增大脾小结(t=3.36~11.97,P<0.01),增加脾脏淋巴细胞数(t=4.29~10.44,P<0.01);复方阿胶浆30mL/kg组可明显增加小鼠胸腺淋巴细胞数(t=2.45,P<0.05),当归补血口服液组、参芪颗粒3,2,1g/kg组、复方阿胶浆20,10mL/kg组、贞芪扶正颗粒15,10,5g/kg组、复方皂矾丸2.4g/kg组作用更为显著(t=3.22~8.20,P<0.01)。结论:①四种中成药对气血双虚模型小鼠血红蛋白升高作用相近,以复方阿胶浆和贞芪扶正颗粒对白细胞和红细胞水平升高作用为强,以复方阿胶浆和贞芪扶正颗粒对血小板水平升高作用为优。②四种中成药对气血双虚模型小鼠血细胞比容的影响无差异,以贞芪扶正颗粒和复方皂矾丸对巨噬细胞集落刺激因子水平的升高作用为优。③以参芪颗粒、复方阿胶浆、贞芪扶正颗粒对胸腺皮质厚度和淋巴细胞数的促进作用为优,以参芪颗粒、贞芪扶正颗粒、复方皂矾丸对脾小结和脾脏淋巴细胞数的促进作用为优。 相似文献