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71.
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Akiko Danjo Kanako Yamaguchi Kazuma Fujimoto Toshihito Saitoh Masahiko Inamori Takashi Ando Tomohiko Shimatani Kyoichi Adachi Fukunori Kinjo Shiko Kuribayashi Shoji Mitsufuji Yasuhiro Fujiwara Shigeki Koyama Junichi Akiyama Atsushi Takagi Noriaki Manabe Hiroto Miwa Yasuyuki Shimoyama Motoyasu Kusano 《Journal of gastroenterology and hepatology》2009,24(4):633-638
Background and Aim: We compared endoscopic findings of the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG), a written questionnaire developed in Japan, to that for the questionnaire for the diagnosis of reflux esophagitis (QUEST) for the diagnosis of reflux esophagitis. Methods: We registered 475 patients with untreated symptoms of upper abdominal pain (male/female: 252/223, average age 52.4 ± 17.8 years). Subjects were assessed first with the FSSG and QUEST questionnaires, then by endoscopy, before allocation to a gastric ulcer (GU), duodenal ulcer (DU), gastroesophageal reflux disease (GERD) or functional dyspepsia (FD) group. Results: On the basis of the endoscopic findings the diagnoses for the 475 subjects were as follows: FD 52.2%, DU 7.6%, GU 7.8%, and GERD 32.4% (Grade M 10.1%, Grade A + B 20.2%, Grade C + D 2.3%). There was no difference between the FSSG and QUEST in sensitivity, specificity or accuracy for any condition. The FSSG score rose with increasing endoscopic severity of GERD, but there was no correlation between the QUEST score and endoscopic severity. The FSSG total score was inferior to QUEST in terms of distinguishing GERD from other conditions, but when only the questions relating to reflux symptoms were used, the FSSG was able to distinguish GERD from other conditions as well as QUEST. Conclusions: The FSSG score reflects the severity of the endoscopic findings of GERD. 相似文献
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Three cases of hereditary nonspherocytic hemolytic anemia associated with red blood cell glutathione deficiency 总被引:1,自引:2,他引:1
Hirono A; Iyori H; Sekine I; Ueyama J; Chiba H; Kanno H; Fujii H; Miwa S 《Blood》1996,87(5):2071-2074
Three unrelated Japanese patients with chronic nonspherocytic hemolytic anemia wer found to have marked deficiency of red blood cell (RBC) reduced glutathoine (GSH) (4.4%, 13.1%, and 6.9% of normal, respectively). A panel of RBC enzyme assays showed that one patient had decreased glutathione synthetase activity and the other two were moderately deficient in gamma-glutamylcystine synthetase. Some family members of each patient showed mild deficiency of the respective enzymes. RBCs of these patients also showed a decreased level of glutathione-S-transferase as in previously described GSH-deficient cases. Hemolytic anemia was their only manifestation, and neither 5- oxoprolinemia nor 5-oxoprolinuria, which are usually associated with to generalized type of glutathione synthetase deficiency, was noted in our patients. 相似文献
78.
Shoichiro Hirose M.D. Hideo Honjou Hikohito Nakagawa Keigo Nishimura Yoshitaka Kuroda Masahiko Tsuji Atsuo Miwa Masanobu Kitagawa 《Journal of gastroenterology》1989,24(5):481-487
Clinical and pathological characteristics of scirrhous carcinoma of the stomach were studied in 106 cases treated by gastrectomy
between 1973 and 1983. The male to female ratio was 0.58. The percentage of scirrhous carcinomas to all gastric carcinomas
resected in the same period was three times higher in females than males. The age distribution of the patients suggested that
there were two peaks in the forties and sixties in the male, and in the thirties and fifties in the female. The incidence
of scirrhous carcinoma in all types of gastric carcinoma was significantly higher in the twenties, thirties and forties compared
to the lowest incidence in the seventies. In the female group the primary lesion had a tendency to be adjacent to the fundic
gland area and to avoid intestinal metaplasia. In the male the opposite was recognized. Cancer nests with single cells or
only several cells were common in this type of carcinoma. These findings suggest that there might be two biologically different
scirrhous carcinomas both in the male and the female, the appearance of single carcinoma cells might be favored by female
sex hormones and young ages, and not only the original gastric mucosa but also mucosa with intestinal metaplasia could be
precursors of single carcinoma cells. 相似文献
79.
N Satozawa K Takezawa T Miwa S Takahashi M Hayakawa H Ooka 《Growth hormone & IGF research》2000,10(4):187-192
Antidiuretic actions induced by two growth hormone (GH) isoforms (20 K- and 22 K-hGH; 0.2 and 2.0 mg/kg) were evaluated in rats, as fluid retention may cause oedema, one of the adverse effects of GH. Both GH isoforms (2.0 mg/kg) suppressed urine excretion in hypophysectomized rats (P< 0.01), but only the 22 K-hGH isoform (2.0 mg/kg) suppressed urine excretion in intact rats (P< 0.01). In addition, prolactin (PRL) suppressed urine excretion in intact rats (P< 0.05). In conclusion, 20 K-hGH has less potency in causing urine retention than 22 K-hGH and since 20 K-hGH is missing 15 amino acids found in 22 K-hGH, these amino acids may be important for the antidiuretic action of GH. Since prolactin suppressed urine excretion, a part of the antidiuretic action of GH may be related to PRL-R activation. 相似文献
80.
BACKGROUND--Shunt vessels were imaged and shunt flow was analysed by cross sectional and Doppler echocardiography in 12 patients who had had 14 shunt procedures (nine left Blalock-Taussig shunts, three right Blalock-Taussig shunts, one modified Waterston shunt, and one central shunt). METHODS--The shunt vessels were classified by echocardiography as uniformly patent, segmentally stenosed, and uniformly stenosed. These findings were compared with those of angiography. Also the peak flow velocities at the aortic and the pulmonary ends of the shunt vessels were measured by Doppler echocardiography and the ratio of these values was calculated for each shunt. RESULTS--Twelve (85.7%) of 14 shunt vessels were imaged along their entire length by cross sectional echocardiography. The two remaining shunt vessels were only partially imaged. In 10 patients who also had angiography the echocardiographic and angiographic images of the shunt vessels were identical. The ratio of the peak flow velocity measured at the aortic and the pulmonary ends of the shunt vessel was significantly larger in the segmentally stenosed shunt vessels than in the uniformly patent shunt vessels (p < 0.001). The ratio in the two shunt vessels only partially imaged by cross sectional echocardiography indicated that they were segmentally stenosed. CONCLUSION--The combination of cross sectional and Doppler echocardiography may be useful for determining either the patency or the morphology of an aortopulmonary shunt. 相似文献