全文获取类型
收费全文 | 841篇 |
免费 | 59篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 17篇 |
妇产科学 | 6篇 |
基础医学 | 145篇 |
口腔科学 | 22篇 |
临床医学 | 45篇 |
内科学 | 131篇 |
皮肤病学 | 12篇 |
神经病学 | 78篇 |
特种医学 | 39篇 |
外科学 | 77篇 |
预防医学 | 36篇 |
眼科学 | 98篇 |
药学 | 82篇 |
中国医学 | 1篇 |
肿瘤学 | 103篇 |
出版年
2023年 | 5篇 |
2022年 | 7篇 |
2021年 | 12篇 |
2020年 | 8篇 |
2019年 | 12篇 |
2018年 | 19篇 |
2017年 | 17篇 |
2016年 | 10篇 |
2015年 | 20篇 |
2014年 | 29篇 |
2013年 | 37篇 |
2012年 | 46篇 |
2011年 | 40篇 |
2010年 | 28篇 |
2009年 | 22篇 |
2008年 | 47篇 |
2007年 | 61篇 |
2006年 | 50篇 |
2005年 | 56篇 |
2004年 | 54篇 |
2003年 | 73篇 |
2002年 | 55篇 |
2001年 | 8篇 |
2000年 | 15篇 |
1999年 | 22篇 |
1998年 | 6篇 |
1997年 | 8篇 |
1996年 | 12篇 |
1995年 | 3篇 |
1994年 | 8篇 |
1993年 | 6篇 |
1992年 | 12篇 |
1991年 | 11篇 |
1990年 | 7篇 |
1989年 | 4篇 |
1988年 | 7篇 |
1987年 | 10篇 |
1986年 | 9篇 |
1985年 | 2篇 |
1984年 | 13篇 |
1983年 | 5篇 |
1981年 | 6篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1969年 | 2篇 |
1966年 | 1篇 |
1963年 | 1篇 |
1925年 | 1篇 |
1924年 | 2篇 |
排序方式: 共有903条查询结果,搜索用时 31 毫秒
11.
Nakagawa M Suehara M Saito A Takashima H Umehara F Saito M Kanzato N Matsuzaki T Takenaga S Sakoda S Izumo S Osame M 《Neurology》1999,52(6):1271-1275
We found the association of a heterozygous novel MPZ gene point mutation, Ile62Phe in exon 2, with autosomal dominant motor and sensory neuropathy with focally folded myelin sheaths. Family study revealed that de novo Ile62Phe mutation on the MPZ gene occurred in the proband and was inherited by her children with early onset slowly progressive neuropathy. Our study suggests that the characteristic pathologic findings of the sural nerve in these patients are closely related to the site and nature of amino acid substitutions of the MPZ gene. 相似文献
12.
Yano H Suetake M Endo H Takayanagi R Numata M Ohyama K Sagai S Okitsu N Okamoto M Nishimura H Kobayashi T 《The Journal of infection》2005,51(4):e237-e240
Measles virus was isolated from the middle ear fluid (MEF) of two infant cases of acute otitis media (AOM) associated with measles. This is the first report on the isolation of measles virus from the MEF in patients with AOM, and possibility of the measles virus as a causative agent of AOM was suggested. 相似文献
13.
14.
Tadashige Nozaki Hiroaki Fujimori Junhui Wang Hiroshi Suzuki Hiroshi Imai Masatoshi Watanabe Kiyoshi Ohura Mitsuko Masutani 《Pathology international》2013,63(8):408-414
Embryonic stem (ES) cells deficient in poly(ADP‐ribose) polymerase‐1 (Parp‐1) develop into teratocarcinomas with the appearance of trophoblast giant cells (TGCs) when injected subcutaneously into nude mice. Because the uterus is one of the original organs in which germ cell tumors develop with induction of trophoblast lineage, here we investigated whether Parp‐1 deficiency in ES cells affects teratocarcinoma formation processes by grafting ES cells into the horns of uteri. Teratocarcinomas developed from both wild‐type (Parp‐1+/+) and Parp‐1?/? ES cells. The weights of the tumors derived from Parp‐1?/? ES cells were lower than those of the tumors derived from Parp‐1+/+ ES cells (P < 0.05). The Parp‐1?/? tumors showed the appearance of TGCs. Notably, organ metastasis to the lung and liver was observed for the Parp‐1?/? tumors, but not for the Parp‐1+/+ tumors (P < 0.05). Invasions were more frequently observed with the Parp‐1?/? tumors compared with the Parp‐1+/+ tumors (P < 0.05). Since TGCs are known to have invasive properties, the appearance of TGCs may have supported the metastatic process. The present findings suggest that loss of Parp‐1 during teratocarcinoma formation might augment invasive and metastatic properties of the tumors in the uterine environment. 相似文献
15.
Kotaro Sugimoto Akira Takasawa Shingo Ichimiya Masaki Murata Hiromichi Kimura Tomoyuki Aoyama Johan J.P. Gille Naoto Kuroda Hiroshi Shimizu Tadashi Hasegawa Norimasa Sawada Mitsuko Furuya Yoji Nagashima 《Pathology international》2013,63(10):510-515
Chromophobe renal cell carcinoma (RCC) accounts for approximately 5% of renal epithelial neoplasms. Multiple and/or bilateral chromophobe RCCs in an individual are generally rare but frequently occur in patients with Birt–Hogg–Dubé syndrome (BHDS) and in patients with tuberous sclerosis complex (TSC). The responsible genes in both BHDS and TSC act as tumor suppressors. Therefore, it seems that some genetic backgrounds are required for the generation and progression of multiple chromophobe RCCs. Here, we report a case of multiple and bilateral chromophobe RCCs along with several small‐sized capsular angiomyolipomas known as ‘capsulomas’ in a 39‐year‐old woman who had neither a particular medical history nor specific gene mutation. There has been no report of sporadic multiple chromophobe RCCs and ‘capsulomas’ developing in a patient without genetic features, having potential for novel genetic variation. 相似文献
16.
Ohshima S Kobayashi H Yamaguchi N Nishioka K Umeshita-Sasai M Mima T Nomura S Kon S Inobe M Uede T Saeki Y 《Arthritis and rheumatism》2002,46(4):1094-1101
OBJECTIVE: To investigate the involvement of osteopontin (OPN) in bone destruction in a murine experimental arthritis model of collagen-induced arthritis (CIA). METHODS: The expression of OPN was examined at both the messenger RNA (mRNA) and protein levels in various arthritic lesions in mice with CIA by in situ hybridization and immunohistochemistry, respectively. In addition, the expression of alpha(v)beta3 integrin, a receptor for OPN, the ligation of which is thought to be essential for bone resorption by osteoclasts, was examined by immunohistochemistry. Plasma concentrations of OPN were measured at different time points in the course of CIA by enzyme-linked immunosorbent assay. RESULTS: OPN mRNA was detected mainly at sites of bone erosion in arthritic lesions, where activated osteoclasts were present; OPN protein was also detected at sites of bone erosion. In the arthritic synovium, OPN was predominantly expressed in the synovial lining layer, but not in lymphoid aggregates. In addition, alpha(v)beta3 integrin was detected coincident with OPN at sites of bone erosion (bone-pannus junction). Plasma OPN levels were markedly elevated at the time points that corresponded to arthritis flares, and higher levels were maintained during the progression of arthritis. CONCLUSION: OPN may mediate bone resorption by osteoclasts in arthritis through ligation with its receptor, alpha(v)beta3 integrin. OPN may be a useful therapeutic target molecule in the prevention of bone destruction in arthritis. 相似文献
17.
Yoshihiro Sudo Yoichi Ezura Ryota Ishida Mitsuko Kajita Hideyo Yoshida Takao Suzuki Takayuki Hosoi Satoshi Inoue Masataka Shiraki Hajime Orimo Hiromoto Ito Mitsuru Emi 《Geriatrics & Gerontology International》2004,4(4):245-249
Background: Osteoporosis is believed to result from the interaction among multiple environmental and genetic determinants that regulate bone-mineral density (BMD).
Methods: To investigate a potentially predisposing genetic factor in the onset of osteoporosis, we looked for a possible association between BMD in adult Japanese women and known polymorphisms in the leukemia inhibitory factor receptor gene (LIFR).
Results: An association analysis of chromosomes from 384 volunteer subjects revealed significant correlation between the −603T > C variant of LIFR and radial BMD ( r = 0.11, P = 0.032) in this test population. Comparisons of mean values of adjusted radial BMD among separate genotypic groups implied an allelic dosage effect, because homozygous carriers of T alleles of that SNP had the highest adjusted BMDs (0.403 ± 0.054 g/cm2 ); women homozygous for the C-allele had the lowest (0.373 ± 0.042 g/cm2 ), and heterozygous individuals had intermediate scores (0.394 ± 0.056 g/cm2 ).
Conclusion: This polymorphism in LIFR may be an important determinant of predisposition to postmenopausal osteoporosis. 相似文献
Methods: To investigate a potentially predisposing genetic factor in the onset of osteoporosis, we looked for a possible association between BMD in adult Japanese women and known polymorphisms in the leukemia inhibitory factor receptor gene (LIFR).
Results: An association analysis of chromosomes from 384 volunteer subjects revealed significant correlation between the −603T > C variant of LIFR and radial BMD ( r = 0.11, P = 0.032) in this test population. Comparisons of mean values of adjusted radial BMD among separate genotypic groups implied an allelic dosage effect, because homozygous carriers of T alleles of that SNP had the highest adjusted BMDs (0.403 ± 0.054 g/cm
Conclusion: This polymorphism in LIFR may be an important determinant of predisposition to postmenopausal osteoporosis. 相似文献
18.
19.
Hashizume O Shimizu A Yokota M Sugiyama A Nakada K Miyoshi H Itami M Ohira M Nagase H Takenaga K Hayashi J 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(26):10528-10533
It has been hypothesized that respiration defects caused by accumulation of pathogenic mitochondrial DNA (mtDNA) mutations and the resultant overproduction of reactive oxygen species (ROS) or lactates are responsible for aging and age-associated disorders, including diabetes and tumor development. However, there is no direct evidence to prove the involvement of mtDNA mutations in these processes, because it is difficult to exclude the possible involvement of nuclear DNA mutations. Our previous studies resolved this issue by using an mtDNA exchange technology and showed that a G13997A mtDNA mutation found in mouse tumor cells induces metastasis via ROS overproduction. Here, using transmitochondrial mice (mito-mice), which we had generated previously by introducing G13997A mtDNA from mouse tumor cells into mouse embryonic stem cells, we provide convincing evidence supporting part of the abovementioned hypothesis by showing that G13997A mtDNA regulates diabetes development, lymphoma formation, and metastasis--but not aging--in this model. 相似文献
20.