全文获取类型
收费全文 | 157370篇 |
免费 | 52247篇 |
国内免费 | 6026篇 |
专业分类
耳鼻咽喉 | 2202篇 |
儿科学 | 5249篇 |
妇产科学 | 1373篇 |
基础医学 | 24054篇 |
口腔科学 | 6603篇 |
临床医学 | 22406篇 |
内科学 | 33848篇 |
皮肤病学 | 8296篇 |
神经病学 | 16936篇 |
特种医学 | 5396篇 |
外国民族医学 | 30篇 |
外科学 | 22536篇 |
综合类 | 17196篇 |
现状与发展 | 23篇 |
一般理论 | 36篇 |
预防医学 | 10857篇 |
眼科学 | 3419篇 |
药学 | 14298篇 |
105篇 | |
中国医学 | 6989篇 |
肿瘤学 | 13791篇 |
出版年
2024年 | 318篇 |
2023年 | 1330篇 |
2022年 | 3119篇 |
2021年 | 5351篇 |
2020年 | 8123篇 |
2019年 | 13119篇 |
2018年 | 12581篇 |
2017年 | 13921篇 |
2016年 | 14334篇 |
2015年 | 15427篇 |
2014年 | 16236篇 |
2013年 | 16808篇 |
2012年 | 10704篇 |
2011年 | 11441篇 |
2010年 | 14103篇 |
2009年 | 9789篇 |
2008年 | 7341篇 |
2007年 | 6014篇 |
2006年 | 5863篇 |
2005年 | 4900篇 |
2004年 | 4072篇 |
2003年 | 3910篇 |
2002年 | 3565篇 |
2001年 | 2880篇 |
2000年 | 2434篇 |
1999年 | 1702篇 |
1998年 | 947篇 |
1997年 | 860篇 |
1996年 | 670篇 |
1995年 | 590篇 |
1994年 | 569篇 |
1993年 | 336篇 |
1992年 | 348篇 |
1991年 | 318篇 |
1990年 | 238篇 |
1989年 | 273篇 |
1988年 | 201篇 |
1987年 | 189篇 |
1986年 | 115篇 |
1985年 | 113篇 |
1984年 | 79篇 |
1983年 | 49篇 |
1982年 | 40篇 |
1981年 | 46篇 |
1980年 | 36篇 |
1979年 | 34篇 |
1978年 | 23篇 |
1977年 | 21篇 |
1975年 | 18篇 |
1974年 | 21篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
141.
142.
目的 探讨血清谷丙转氨酶(ALT)与新诊2型糖尿病(T2DM)患病风险之间的关联,为T2DM的防治提供科学依据。方法 采用4阶段分层随机抽样的方法选取2006年和2009年参与青岛糖尿病预防项目的研究对象男性3 012例、女性4 422例,采用Pearson相关检验分析不同性别ALT与FPG、2 h PG的相关性,并利用多因素logistic回归分析ALT与新诊T2DM患病的关系。结果 男性中,ALT与空腹血浆血糖(FPG)、餐后2 h血浆血糖(2 h PG)的Pearson相关系数分别为0.088、0.080(均P<0.01);多因素logistic回归显示,在调整了年龄、BMI、糖尿病家族史、城乡、教育、婚姻、收入、吸烟及饮酒状况等混杂因素后,ALT的第4分位(Q4)组新诊T2DM患病风险是第1分位(Q1)组的1.832倍(OR = 1.832,95% CI:1.324~2.534,P<0.01)。女性中,ALT与FPG、2h PG的Pearson相关系数分别为0.065、0.108(均P<0.01);多因素logistic回归显示,在调整了年龄、BMI、糖尿病家族史、城乡、教育、婚姻、收入、吸烟及饮酒状况等混杂因素后,ALT的第4分位(Q4)组新诊T2DM患病风险是第1分位(Q1)组的1.445倍(OR = 1.445,95% CI:1.087~1.919,P<0.05)。结论 在男、女性人群中,ALT水平升高与T2DM患病相关,且这种相关性不受年龄、BMI、糖尿病家族史等的影响。 相似文献
143.
144.
145.
146.
Xue Yao Yan Zhang Jian Hao Hui-Quan Duan Chen-Xi Zhao Chao Sun Bo Li Bao-You Fan Xu Wang Wen-Xiang Li Xuan-Hao Fu Yong Hu Chang Liu Xiao-Hong Kong Shi-Qing Feng 《中国神经再生研究》2019,(3)
Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It has yet to be clarified whether ferroptosis inhibition represents the mechanism of action of Deferoxamine on spinal cord injury recovery. A rat model of Deferoxamine at thoracic 10 segment was established using a modified Allen's method. Ninety 8-week-old female Wistar rats were used. Rats in the Deferoxamine group were intraperitoneally injected with 100 mg/kg Deferoxamine 30 minutes before injury. Simultaneously, the Sham and Deferoxamine groups served as controls. Drug administration was conducted for 7 consecutive days. The results were as follows:(1) Electron microscopy revealed shrunken mitochondria in the spinal cord injury group.(2) The Basso, Beattie and Bresnahan locomotor rating score showed that recovery of the hindlimb was remarkably better in the Deferoxamine group than in the spinal cord injury group.(3) The iron concentration was lower in the Deferoxamine group than in the spinal cord injury group after injury.(4) Western blot assay revealed that, compared with the spinal cord injury group, GPX4, xCT, and glutathione expression was markedly increased in the Deferoxamine group.(5) Real-time polymerase chain reaction revealed that, compared with the Deferoxamine group, mRNA levels of ferroptosis-related genes Acyl-CoA synthetase family member 2(ACSF2) and iron-responsive element-binding protein 2(IREB2) were up-regulated in the Deferoxamine group.(6) Deferoxamine increased survival of neurons and inhibited gliosis. These findings confirm that Deferoxamine can repair spinal cord injury by inhibiting ferroptosis. Targeting ferroptosis is therefore a promising therapeutic approach for spinal cord injury. 相似文献
147.
148.
149.
150.
Phenotypic and genetic features of enteropathogenic Escherichia coli isolates from diarrheal children in the Ribeirão Preto metropolitan area,São Paulo State,Brazil
下载免费PDF全文
![点击此处可从《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》网站下载免费的PDF全文](/ch/ext_images/free.gif)
André Pitondo‐Silva Gerson Nakazato Juliana P. Falcão Kinue Irino Roberto Martinez Ana Lúcia C. Darini Rodrigo Tavanelli Hernandes 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2015,123(2):128-135
This study was designed to characterize a collection of 60 enteropathogenic Escherichia coli (EPEC) isolates from diarrheic feces of patients in the Ribeirão Preto metropolitan area regarding different phenotypic and molecular features. We examined antibiotic resistance profiles, occurrence of virulence factors‐encoding genes, intimin subtypes and the correlation of serotypes among typical (tEPEC) and atypical (aEPEC) EPEC isolates. The results demonstrated that atypical EPEC was more heterogeneous than typical EPEC concerning the characteristics investigated and 45.2% do not belong to classical EPEC serogroups. Intimin subtype β was the most frequent among the EPEC isolates (46.7%), being detected in both tEPEC and aEPEC. The majority of aEPEC isolates presented localized adherence‐like (LAL) pattern to HEp‐2 cells, although aEPEC isolates displaying diffuse adherence (DA) or non‐adherent were also detected. High prevalence of antimicrobial resistance was found for ampicillin, cephalothin, sulfonamide and tetracycline. In general, tEPEC isolates were more resistant to the antimicrobials tested than aEPEC isolates. 相似文献