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61.
Azmi Lubna Shukla Ila Gupta Shyam Sundar Yadav Narayan Prasad Kant Padam Rao Ch. V. 《Proceedings of the National Academy of Sciences, India. Section B.》2019,89(3):1039-1045
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - Chronic gastric ulcer being the most prevalent gastrointestinal disorder is considered a major cause of... 相似文献
62.
Safikur Rahman Ayyagari Archana Durgashree Dutta Vijay Kumar Jihoe Kim Arif Tasleem Jan Rinki Minakshi 《Saudi Pharmaceutical Journal》2019,27(3):437-445
Cannabinoids, commonly used for medicinal and recreational purposes, consist of various complex hydrophobic molecules obtained from Cannabis sativa L. Acting as an inhibitory molecule; they have been investigated for their antineoplastic effect in various breast tumor models. Lately, it was found that cannabinoid treatment not only stimulates autophagy-mediated apoptotic death of tumor cells through unfolded protein response (UPRER) activated downstream effectors, but also imposes cell cycle arrest. The exploitation of UPRER tumors as such is believed to be a major molecular event and is therefore employed in understanding the development and progression of breast tumor. Simultaneously, the data on clinical trials following administration of cannabinoid is currently being explored to find its role not only in palliation but also in the treatment of breast cancer. The present study summarizes new achievements in understanding the extent of therapeutic progress and highlights recent developments in cannabinoid biology towards achieving a better cure of breast cancer through the exploitation of different cannabinoids. 相似文献
63.
Lubna Azmi Ila Shukla Arti Goutam Ch.V. Rao Talha Jawaid Mehnaz Kamal Amani S. Awaad Saleh I. Alqasoumi Osama A. AlKhamees 《Saudi Pharmaceutical Journal》2019,27(4):532-539
Wound healing is a complex process in which injured skin and tissues repaired by interaction of a complex cascade of cellular events that generates resurfacing, reconstitution and restoration of the tensile strength of injured skin. It follows β-catenin, extracellular signal regulated kinase (ERK) and Akt signaling pathways. Aegle marmelos L., generally known as bael is found to act as anti-inflammatory, antioxidant and anti-ulcer agent. Furthermore, studies have demonstrated that this Indian traditional medicinal plant, A. marmelos flower extract (AMF) was used for wound injury. Henceforth, the current study was investigated to ascertain the effect of its active constituents in vitro wound healing with mechanism involve in migration of cells and activation of β-catenin in keratinocytes, inhibition of PGE2 in macrophages and production of collagen in fibroblasts. We have taken full thickness wound of rats and applied AMF for 2 weeks. Cutaneous wound healing activity was performed using HaCaT keratinocytes, Hs68 dermal fibroblasts and RAW264.7 macrophages to determine cell viability, nitric oxide production, collagen expression, cell migration and β-catenin activation. Results shows that AMF treated rats demonstrated reduced wound size and epithelisation was improved, involved in keratinocytes migration by regulation of Akt signaling, beta-catenin and extracellular signal-regulated kinase (ERK) pathways. AMF and its active constituent’s increased mRNA expression, inhibited nitric oxide, PGE2 release, mRNA expression of mediators in RAW 264.7 macrophages and enhances the motility of HaCaT keratinocytes in vitro wound healing of rats. 相似文献
64.
Kamal Dua Ridhima Wadhwa Gautam Singhvi Vamshikrishna Rapalli Shakti Dhar Shukla Madhur D. Shastri Gaurav Gupta Saurabh Satija Meenu Mehta Navneet Khurana Rajendra Awasthi Pawan Kumar Maurya Lakshmi Thangavelu Rajeshkumar S Murtaza M. Tambuwala Trudi Collet Philip M. Hansbro Dinesh Kumar Chellappan 《Drug development research》2019,80(6):714-730
65.
66.
Saangeeta Shukla 《Phytotherapy research : PTR》1996,10(2):95-99
Biochemical and physiological alterations have been observed in the ovary and uterus of pregnant rats treated with an extract of Pueraria tuberosa DC. Its administration from day 1 to 5 post-coitally caused a significant increase in the wet weight, protein and glycogen contents. Activity of acid phosphatase and ATPase was depleted sharply on days 4 and 5, but the activity of alkaline phosphatase was elevated on days 4 and 5. Ovaries of treated rats showed an increased number of follicles of different age. Cells of the corpora lutea showed hypertrophy. Uterine histoarchitecture appeared nonreceptive on the day of implantation. No deciduoma was observed on day 5. These changes have been correlated with the antiimplantation action of the butanol extract. 相似文献
67.
Yamini B. Tripathi Savita Shukla Savita Chaurasia Shashikant Chaturvedi 《Phytotherapy research : PTR》1996,10(3):269-270
We have investigated the effect of shilajit on lipid peroxidation and glutathione content in rat liver homogenate. It inhibited lipid peroxidation induced by cumene hydroperoxide and ADP/Fe++ complex in a dose dependent manner. It also reduced the rate of oxidation of reduced glutathione content and inhibited ongoing lipid peroxidation, induced by these agents immediately after its addition to the incubation system. 相似文献
68.
Ursolic acid isolated from the leaves and stems of Duboisia myoporoides (Solanaceae) was bioassayed by leaf disc method for feeding deterrence using Spilosoma obliqua and Spodoptera litura as test insects. This compound was proved to be a potent antifeedant under laboratory conditions. Azadirachtin was used as standard. Ursolic acid produced 90.12% and 91.96% inhibition at 5000 ppm concentration, respectively, against S. obliqua and S. litura . 相似文献
69.
Administration of CCl4 at a dose of 0.1 mL/kg/day for 7 days to normal rats provoked significant alterations in the various biochemical variables. It also caused severe histopathological lesions. Priming with the butanol extract of P. tuberosa or conjoint administration of extract along with CCl4, provided significant protection against CCl4 induced injury. 相似文献
70.
Arunaloke Chakrabarti Prashant Sood Shivaprakash M. Rudramurthy Sharon Chen Joseph Jillwin Ranganathan Iyer Ajanta Sharma Belgode Narasimha Harish Indranil Roy Anupma J. Kindo Deepinder Chhina Jayanthi Savio Deepak Mendiratta Malini R. Capoor Shukla Das Anita Arora Jagdish Chander Immaculata Xess Appalaraju Boppe Ujjwayini Ray Ratna Rao Vandana Kalwaje Eshwara Sangeeta Joshi Atul Patel Raman Sardana Anjali Shetty Umabala Pamidimukkala for the SIHAM Candidemia Network 《Mycoses》2020,63(11):1149-1163