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101.
102.
Chlebus P Mikl M Brázdil M Pazourková M Krupa P Rektor I 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2007,179(3):365-374
Several functional MR imaging studies evaluating the lateralisation of linguistic functions in patients who underwent Wada
testing have been reported. There is extensive variance in the Laterality index (LI) calculation across the studies, and the
optimal calculation method remains unclear. We attempted to calculate the LI in different ways in the same subjects, in order
to find the LI calculation method with the highest correlation to the Wada test. Fifteen patients (10 females, 5 males) suffering
from medically intractable temporal lobe epilepsy (TLE) (12 left, 3 right) were admitted for the study. The patients underwent
a standardized bilateral intracarotid short-acting barbiturate test. Language testing included spontaneous speech, oral comprehension,
reading, object and picture naming, and repetition. All the tasks were scored separately in order to increase the possibility
of correlation between Wada and LI. A silent phonemic verbal fluency task (VFT) was used as a language paradigm for functional
measurement. Regions of interest (ROIs), with a known association with language function (Broca’s area, the lateral prefrontal
cortex, etc.), were defined. First, the LIs were calculated from the ROIs using a previously reported method (simple suprathreshold
count). Next, we used several new methods of LI calculation (t–weighting of voxels, methods independent of the choice of the statistical threshold, etc.) The most significant correlation
with Wada was proven in the LIs that were evaluated from Broca’s area (up to R = 0.94, P = 1 × 10−7). However, the new LI calculation methods used in the present study did not produce a statistically significant benefit in
comparison to previously reported methods. 相似文献
103.
104.
Biological evaluation of selected 3,4‐dihydro‐2(1H)‐quinoxalinones and 3,4‐dihydro‐1,4‐benzoxazin‐2‐ones: Molecular docking study
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Jelena Petronijević Nenad Janković Tatjana P. Stanojković Nenad Joksimović Nađa Đ. Grozdanić Milan Vraneš Aleksandar Tot Zorica Bugarčić 《Archiv der Pharmazie》2018,351(5)
105.
Alexandra Kmetova Eva Kralikova Lenka Stepankova Kamila Zvolska Milan Blaha Michal Sticha Zbynek Bortlicek Darrell R. Schroeder Ivana T. Croghan 《Addictive behaviors》2014
Objective
To identify possible predictors of post-cessation weight gain in smoking abstainers.Patients and methods
A sample of 607 successful abstainers seen at the Centre for Tobacco-Dependent in Prague, Czech Republic, between 2005 and 2010, was included in this analysis. This sample was followed up for 1 year and included 47.9% women (N = 291) with the mean age of 48 years (18–85).Findings
Post-cessation weight gain occurred in 88.6% of the 607 abstainers. The mean weight gain after one year post-quit was 5.1 kg (95% confidence interval 4.7–5.5 kg). Baseline characteristics associated with increased weight gain included a higher baseline smoking rate (p < 0.001), more severe cigarette dependence (p = 0.003), less physical activity (p = 0.008), and a report of increased appetite on the baseline assessment of withdrawal symptoms (p < 0.001).Conclusions
Smokers who are more dependent and have minimal physical activity are at increased risk for post-cessation weight gain. For these smokers, incorporating interventions targeting the weight issue into tobacco dependence treatment is recommended. Further research should be done to identify reasons for this important quitting complication. 相似文献106.
Lenka Kucharikov Denisa Medveck Eva Tillov Juraj Belan Michaela Kritikos Mria Chalupov Milan Uhrí
ik 《Materials》2021,14(8)
Secondary-cast aluminum alloys have increasing industrial applications. Their biggest deficiency is their impurity content, especially Fe, which has low solubility in Al and almost all the content creates intermetallic phases. This work examines the effect of higher Fe content on the microstructure and properties of A356.0 alloy. At the same time, no other possibility existed to affecting the brittleness of the formation of the β phases. The calculation of Fecrit, ratio of Mn/Fe, quantitative and computed tomography analysis of porosity and Fe plate-like phases, measurement of mechanical and fatigue properties, and fractography analysis were performed in this study. The results show that gravity die casting into a sand mold, and the non-usage of Mn addition or heat treatment, do not have a negative effect on increasing the size of the Fe-rich plate-like phases. The longest Fe-rich phases have limited the pore growth and ratios, but their higher thickness led to greater porosity formation. The mechanical and fatigue properties correlate with the Fecrit level and the highest were for the experimental alloy with 0.454 wt.% of Fe. The experimental results confirmed the fact that if the Fe plate-like phases have a length of up to 50 µm, the fatigue properties depend more on the size of porosity. If the length of the Fe needles is more than 50 µm, then the properties are mainly affected by the length of these Fe phases. 相似文献
107.
108.
Chlamydia pneumoniae infections in patients with community-acquired pneumonia in Slovenia 总被引:1,自引:0,他引:1
It is well known that Chlamydia pneumoniae is an important respiratory pathogen. In this study, the prevalence of specific antibodies to C. pneumoniae in hospitalized patients with community-acquired pneumonia (943 adult females, 990 adult males and 185 children) was evaluated over a period of 7 y (1993-99). Two serum samples were obtained from all of the patients: 1 on admission and the other 3 weeks later. The specimens were tested for C. pneumoniae IgG, IgM and IgA antibodies by means of a microimmunofluorescence test. Acute infection with C. pneumoniae was determined in 9.4% of females and 13.1% of males. In children and adolescent patients, the microimmunofluorescence test showed recent infection in 8.6% of cases, with the highest prevalence occurring in the 11-15 y age group. The highest prevalence of C. pneumoniae pneumonia was found in 1995 and 1999: 15.4% and 13.6% respectively. The results obtained showed that C. pneumoniae is persistently present in the population of Slovenia. 相似文献
109.
Roberto Valle Emanuele Carbonieri Pierluigi Tenderini Carlo Zanella Francesca De Cian Giuliana Ginocchio Sergio Cannas Daniele Milan Loredano Milani 《Italian heart journal. Supplement》2004,5(4):282-291
BACKGROUND: Hospital admissions for heart failure are common and readmission rates are high. Many admissions and readmissions may be avoidable, so that alternative strategies are needed to improve long-term management. METHODS: We conducted a randomized trial of the effect of a guideline-based intervention on rates of readmission within 90 days of hospital discharge and costs of care for patients who were hospitalized due to decompensated heart failure. The intervention consisted of comprehensive education of the patient and family, a prescribed diet and intensive application of guidelines' recommendations on pharmacological therapy. The intervention started before discharge and continued thereafter with follow-up visits for up to 3 months. Two hundred and nine guideline-managed patients were compared to 209 concurrent normally-discharged patients. RESULTS: Patients in the study group were more prescribed beta-blockers, ACE-inhibitors, angiotensin receptor blockers, and spironolactone. Sixteen patients (8%) in the intervention group and 31 (15%) among controls were readmitted for DRG 127, within 3 months of discharge (Fisher's exact test, p < 0.01), while the 6-month mortality rate was similar between groups (9 and 11.5% respectively). Quality of life significantly improved from 5.6 +/- 1.0 to 6.1 +/- 1.9 (Mann-Whitney U-test, p < 0.05). The overall costs of care were lower for guideline-managed patients (110 vs 150 Euro per patient per month), due to the lower readmission rates. CONCLUSIONS: Our study showed that a guideline-based management program for patients with heart failure at discharge improves quality of life and reduces readmission for DRG 127 and total bed days, allowing relevant cost savings. 相似文献
110.
Sébastien Trop John C. Marshall C. David Mazer Milan Gupta Daniel J. Dumont Annie Bourdeau Subodh Verma 《The Journal of surgical research》2014