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11.
K. Sato S. Yamamura H. Sugiura T. Mieno T. Nagasaka N. Nakashima 《Archives of orthopaedic and trauma surgery》1997,116(8):510-513
Gorham syndrome (massive osteolysis) is a very rare tumour-like lesion characterized by progressive osteolysis. The diagnosis must be confirmed by the microscopic finding of intramedullary angioma-like vascular structures. We report a case of a 15-year-old boy with a pathological fracture in his left humerus. Imaging modalities such as magnetic resonance imaging, computed tomography, angiography and bone scintigraphy failed to disclose to tumorous lesion that filled a cavity in the left humerus. After observing the boy's progress for 6 months, a temporary diagnosis of Gorham syndrome was made, and surgical treatment was chosen. After resection of the left humeral head and the proximal one-quarter of the humerus, thorough curettage was performed in the distal humerus and an intramedullary artificial humeral head fixed with adequate success. Pathological examination of the specimen revealed intramedullary haemangioma of the humerus. 相似文献
12.
Summary The present study was designed to evaluate the effects of infrasound on behavioral performance in rats. The rats were divided into two groups, one selected for good performance (six rats: superior group) and the other for poor performance (six rats: inferior group) on the Rota-Rod Treadmill.Exposure conditions were as follows:Exp. 1 Control (150 min), Exp. 2 Exposure to infrasound with a main frequency of 16 Hz and a sound pressure level of 105 dB (S.P.L.) (70 min), Exp. 3 Exposure to infrasound with a main frequency of 16 Hz and a sound pressure level of 95 dB (S.P.L.) (70 min), Exp. 4 Exposure to infrasound with a main frequency of 16 Hz and a sound pressure level of 85 dB (S.P.L.) (150 min), Exp. 5 Exposure to infrasound with a main frequency of 16 Hz and a sound pressure level of 75 dB (S.P.L.) (150 min), Exp. 6 Exposure to Pink Noise of 72 dB (A) (70 min).Comparison of the pre-exposure endurance time (Maximum: 2 min) on the Rota-Rod Treadmill with endurance after exposure to infrasound showed that the endurance time of the superior group after exposure to 16 Hz, 105 dB was not reduced. The endurance of the inferior group was reduced by exposure to 16 Hz, 105 dB after 10 min, to 16 Hz, 95 dB after 70 min, and to 16 Hz, 85 dB after 150 min. 相似文献
13.
Relationship between HLA-D and in vitro and in vivo responsiveness to Candida allergen. 总被引:1,自引:2,他引:1 下载免费PDF全文
Y Nose K Komori H Inouye K Nomura M Yamamura K Tsuji 《Clinical and experimental immunology》1980,40(2):345-350
In vitro reaction to Candida allergen was studied in 100 normal healthy Japanese and related to HLA. A significant association was found between the low responder group (< 7,000 c.p.m.) and HLA-B15 and the high responder group (> 7,000 c.p.m.) and HLA-B7, as well as Dwl. Four HLA-D homozygote cells of types HLA-Dwl and DHO, were tested; these fitted in the high responder group. HLA-DYT and DEn fitted into the low responder group. Responsiveness to Candida allergen corresponded to skin test (r = 0.884, P < 0.01). From these results, in vitro lymphocyte reaction to Candida allergen and skin tests showed close correlation and an association with HLA antigens, HLA-D in particular. 相似文献
14.
Adjuvant activity of synthetic 6-O-"mycoloyl"-N-acetylmuramyl-L-alanyl-D-isoglutamine and related compounds. 下载免费PDF全文
I Azuma K Sugimura M Yamawaki M Uemiya S Kusumoto S Okada T Shiba Y Yamamura 《Infection and immunity》1978,20(3):600-607
Adjuvant and antitumor activities of synthetic 6-O-"mycoloyl"-N-acetylmuramyl-L-alanyl-D-isoglutamine were examined. All the synthetic 6-O-corynomycoloyl-, 6-O-mocardomycoloyl-, and 6-O-mycoloyl-N-acetylmuramyl-L-alanyl-D-isoglutamine were active as adjuvants for cell-mediated immune responses. However, 6-O-mycoloyl-N-acetylmuramyl-L-alanyl-D-isoglutamine was less active as an adjuvant on circulating antibody formation. It was shown that pyrogenic activity of N-acetylmuramyldipeptide was reduced by 6-O-acylation with mycolic acid, but not with nocardomycolic or corynomycolic acid. Tumor-suppression activity was observed by the synthetic 6-O-mycoloyl-N-acetylmuramyl-L-alanyl-D-isoglutamine by using transplantable tumor in syngenic mice. 相似文献
15.
Effect of serum amyloid P component level on transthyretin-derived amyloid deposition in a transgenic mouse model of familial amyloidotic polyneuropathy. 下载免费PDF全文
T. Murakami S. Yi S. Maeda F. Tashiro K. Yamamura K. Takahashi K. Shimada S. Araki 《The American journal of pathology》1992,141(2):451-456
To elucidate the pathogenesis of amyloid deposition associated with familial amyloidotic polyneuropathy (FAP), we developed several transgenic mouse lines carrying the human mutant transthyretin (TTR) gene. We found that human TTR and mouse serum amyloid P component (SAP) are deposited as amyloid in tissues of these mouse lines. Because SAP is a major acute-phase reactant in mice, we asked whether repeated injections of Escherichia coli lipopolysaccharide (LPS) would enhance the amyloid deposition in one of these transgenic mouse lines. During the course of repeated LPS injections, serum levels of SAP in the transgenic mice remained between severalfold to about 50-fold higher than seen in the absence of stimulation. As no significant difference was detected in the onset, progression, and tissue distribution of TTR-derived amyloid (ATTR) deposition between the LPS-stimulated and unstimulated transgenic mice, the induction of SAP synthesis by acute inflammation probably does not affect the onset and extent of ATTR deposition. 相似文献
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18.
Adjuvant Activity of 6-Amino-6-Deoxy-Muramyldipeptides and Their Acylamino Derivatives on the Induction of Delayed Hypersensitivity to Azobenzenearsonate-N-Acetyl-l-Tyrosine in Guinea Pigs 下载免费PDF全文
Ichiro Azuma Hiroyuki Okumura Ikuo Saiki Yoshiro Tanio Makoto Kiso Akira Hasegawa Yuichi Yamamura 《Infection and immunity》1981,32(3):1305-1308
The 6-amino-6-deoxy-N-acetylmuramyldipeptides and their 6-acylamino derivatives were shown to be active as adjuvants on the induction of delayed-type hypersensitivity to azobenzenearsonate-N-acetyl-l-tyrosine in guinea pigs. However, 6-acylamino-6-deoxy-N-(acyl)muramyldipeptides were inactive as adjuvants. 相似文献
19.
The manner of packing of the terminal DNA loci into nucleosomes and higher order structures may strongly influence their functional
interactions. Besides the structural flexibility of telomeric DNA sequences, conserved features of their chromatin including
short nucleosome phasing (157 bp) and nucleosome sliding have been described previously. To gain a complementary knowledge
of subtelomeres, we have analysed the chromatin structure of two subtelomeric tandem repeats from the plant Silene latifolia: X43.1 and 15Ssp. X43.1 shows two distinct nucleosome periodicities – 157 and 188 bp. Preferred positions of its two nucleosomes
have been mapped at both low and high resolution and the experimental results correspond to computer-predicted positions.
15Ssp is a newly-discovered sequence showing a telomere-associated position by PCR and a subtelomeric location by pulsed-field
gel electrophoresis and fluorescence in situ hybridisation. Its 159 bp sequence unit shows a tandem arrangement and the presence of micrococcal nuclease-hypersensitive
sites when either naked DNA or chromatin is digested. Use of a chemical nuclease results in a regular nucleosome ladder of
157 bp periodicity. Moreover, 15Ssp mononucleosomes show instability and absence of specific positioning, features typical
for telomeric chromatin.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
20.
Mice lacking smooth muscle calponin display increased bone formation that is associated with enhancement of bone morphogenetic protein responses 总被引:5,自引:0,他引:5