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Yusuke Nakade Tadashi Toyama Kengo Furuichi Shinji Kitajima Yoshiyasu Miyajima Mihiro Fukamachi Akihiro Sagara Yasuyuki Shinozaki Akinori Hara Miho Shimizu Yasunori Iwata Hiroyasu Oe Mikio Nagahara Hiroshi Horita Yoshio Sakai Shuichi Kaneko Takashi Wada 《Clinical and experimental nephrology》2015,19(5):909-917
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Hideo Wada Miho Sakakura Fumihiko Kushiya Masakatu Nisikawa Katsuya Onishi Kaname Nakatani Hiroshi Shiku Tsutomu Nobori 《Blood coagulation & fibrinolysis》2005,16(1):17-24
Thrombomodulin (TM) has been under development as a medicine for disseminated intravascular coagulation (DIC), and is expected to exhibit strong anticoagulant activity by inhibiting thrombin generation via the acceleration of protein C activation. In the present study, we examined the pharmacological action of TM in plasma obtained from DIC patients. TM was found to inhibit thrombin generation and accelerate activated protein C (APC) production at 0.3-30 TM units/ml in plasma obtained from DIC patients irrespective of their underlying disorders. In addition, there was a positive correlation between the inhibition of thrombin generation and the amount of APC produced. Thrombin generation was inhibited by over 50% when the plasma level of APC was increased by more than 0.2 microg/ml. These results indicate that TM inhibits thrombin generation in plasma obtained from DIC patients by accelerating APC production. Moreover, the results imply that the thrombin generation test may be a good method to speculate the efficacy of TM on every patient before the administration of TM. 相似文献
86.
Shinji Morimoto Yoshio Fujioka Hiroshi Hosoai Takahiro Okumura Miho Masai Tsuyoshi Sakoda Takeshi Tsujino Mitsumasa Ohyanagi Tadaaki Iwasaki 《Hypertension research》2003,26(4):315-323
Triglyceride-rich lipoproteins have been suggested to promote atherosclerosis. Plasminogen activator inhibitor type 1 (PAI-1) plays an important role in the events of cardiovascular pathophysiology. The renin-angiotensin system influences various vascular functions, including PAI-1 production. We examined whether or not chylomicron remnants increased PAI-1 mRNA and protein production in endothelial cells and whether or not an inhibition of the renin-angiotensin system interfered with this effect. Chylomicron remnants were isolated from functionally hepatectomized rats injected with chylomicrons. Human umbilical vein endothelial cell cultures (HUVECs) were incubated with chylomicron remnants with or without an angiotensin-converting enzyme inhibitor (temocaprilat), an angiotensin II receptor type 1 antagonist (RNH-6270), or an angiotensin II receptor type 2 antagonist (PD123319). Chylomicron remnants increased PAI-1 secretion in HUVECs (0.5 microg/ml; 128.3 +/- 6.1%, the mean +/- SEM) as well as angiotensin II (10 nmol/l; 130.7 +/- 9.5%) in 18 h, as compared with the controls, as well as stimulated PAI-1 mRNA expression to a maximum level at 4 h. Temocaprilat and RNH-6270, but not PD123319, attenuated all of these effects. Chylomicron remnants enhanced nuclear extract binding to a very low-density lipoprotein response element in the PAI-1 promoter region and activated nuclear factor-kappaB. Extracellular signal-regulated kinase (ERK 1/2) was phosphorylated in response to chylomicron remnants. These effects were inhibited by temocaprilat or RNH-6270. In conclusion, chylomicron remnants increased protein secretion and mRNA expression of PAI-1 in HUVECs. Inhibition of the renin-angiotensin system reduced this stimulation. 相似文献
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Yoshito Tomimaru Nariaki Fukuchi Shigekazu Yokoyama Takuji Mori Masahiro Tanemura Kenji Sakai Yutaka Takeda Masanori Tsujie Terumasa Yamada Atsushi Miyamoto Yasuji Hashimoto Hisanori Hatano Junzo Shimizu Keishi Sugimoto Masaki Kashiwazaki Shogo Kobayashi Yuichiro Doki Hidetoshi Eguchi 《Journal of hepato-biliary-pancreatic sciences》2020,27(8):451-460
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A Y-linked anti-Müllerian hormone duplication takes over a critical role in sex determination 总被引:2,自引:0,他引:2