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排序方式: 共有210条查询结果,搜索用时 343 毫秒
201.
Micol Avenali Cristina Tassorelli Roberto De Icco Armando Perrotta Mariano Serrao Mauro Fresia Claudio Pacchetti Giorgio Sandrini 《Clinical neurophysiology》2017,128(10):1978-1984
Objective
Pain is a frequent non-motor feature in Parkinsonism but mechanistic data on the alteration of pain processing are insufficient to understand the possible causes and to define specifically-targeted treatments.Methods
we investigated spinal nociception through the neurophysiological measure of the threshold (TR) of nociceptive withdrawal reflex (NWR) and its temporal summation threshold (TST) comparatively in 12 Progressive Supranuclear Palsy (PSP) subjects, 11 Multiple System Atrophy (MSA) patients, 15 Parkinson’s disease (PD) subjects and 24 healthy controls (HC). We also investigated the modulatory effect of L-Dopa in these three parkinsonian groups.Results
We found a significant reduction in the TR of NWR and in the TST of NWR in PSP, MSA and PD patients compared with HC. L-Dopa induced an increase in the TR of NWR in the PSP group while TST of NWR increased in both PSP and PD.Conclusions
Our neurophysiological findings identify a facilitation of nociceptive processing in PSP that is broadly similar to that observed in MSA and PD. Specific peculiarities have emerged for PSP.Significance
Our data advance the knowledge of the neurophysiology of nociception in the advanced phases of parkinsonian syndromes and on the role of dopaminergic pathways in the control on pain processing. 相似文献202.
AIMS AND BACKGROUND: To determine the efficacy and safety of the FOLFOX 2 regimen in patients with pretreated advanced colorectal cancer. METHODS: In this single-arm phase II study, 28 patients with heavily pretreated advanced colorectal cancer received the following drug combination: oxaliplatin (100 mg/m2 for 2 hrs on day 1), folinic acid (250 mg/m2 for 2 hrs on day 1) and 5-flluorouracil (1500 mg/m2 for 22 hrs continuous infusion on days 1 and 2) every 2 weeks (one cycle). The treatment was continued until unacceptable toxicity occurred or at most for 10 cycles. RESULTS: Nine patients (32%) had a partial response and 5 (18%) stable disease, with a median duration of tumor control of 24 weeks (range, 8-44). The median survival of patients with a partial response or stable disease was 32 weeks (range, 12-52), whereas the median overall survival was 32 weeks (range, 8-72). A clinical benefit was achieved in 32% (9/21) of the patients. Severe (grade 3-4) non-hematological toxicity included diarrhea (1 patient), nausea/vomiting (7%) and peripheral neuropathy (1 patient). Severe hematological toxicities were rare (4%). CONCLUSIONS: Our phase II study confirmed the therapeutic effectiveness and safety of the FOLFOX 2 regimen in pretreated advanced colorectal cancer patients. 相似文献
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204.
Micol S. Rothman Paul D. Miller E. Michael Lewiecki John P. Bilezikian 《Current osteoporosis reports》2014,12(2):227-229
Dual-energy X-ray absorptiometry (DXA) is an inexpensive, noninvasive, widely available method for diagnosing osteoporosis, assessing fracture risk, and monitoring the effects of therapy. By diagnosing high-risk patients before a fracture occurs, clinicians can intervene early to reduce fracture risk. Appropriate use of DXA results in money saving for healthcare systems that might otherwise be spent for fracture-related care. Recent reports of studies evaluating DXA screening criteria and intervals for retesting have received considerable media coverage, sometimes suggesting that DXA is expensive, over-utilized, and unnecessary. This may lead to more patients who might benefit from early detection of osteoporosis remaining undiagnosed. We advocate for the use of current clinical practice guidelines with individualization of patient care factors to determine the optimal intervals for DXA testing. 相似文献
205.
206.
Chiaffarino F Baldini MP Scarduelli C Bommarito F Ambrosio S D'Orsi C Torretta R Bonizzoni M Ragni G 《European journal of obstetrics, gynecology, and reproductive biology》2011,158(2):235-241
Objective
We have conducted a longitudinal observational study in order to evaluate the prevalence and the incidence of depressive and anxious symptoms in women and men seeking infertility treatment and to analyze associated factors or risk factors for these kinds of disorders.Study design
A total of 1000 consecutive couples that visited our center for the first time were asked to join this study. Depressive and anxious symptoms were assessed with self-rating Zung Depression Scale (ZDS) and Zung Anxiety Scale (ZAS) questionnaires. A second assessment was planned at the time of β HCG dosage (or at the moment of cycle suspension). A standard questionnaire was used to investigate socio-demographic information and the psychological aspects of couples undergoing in vitro fertilization (IVF) treatment. The fertility history and outcome of IVF treatment were collected from patients’ medical records.Results
14.7% of women had anxious symptoms and 17.9% depressive symptoms, whereas 4.5% of men had anxious symptoms and 6.9% depressive symptoms. Women with depressive and anxious symptoms were younger, more often had an anxious partner and had a longer history of infertility. Men with depressive and anxious symptoms more frequently had a temporary job, they had an anxious partner and they were more frequently at the first in vitro fertilization (IVF) cycle.The incidence of depressive and/or anxious symptoms was 18.5% in women and 7.4% in men. Age and previous IVF treatments seem not to be associated with incidence of depressive or anxious symptoms.Conclusion
Both the prevalence and incidence of depressive and/or anxious symptoms in couples undergoing IVF treatment were worthy of note and should not be underestimated. More attention must be paid to psychological aspects in young women and in couples with a long history of infertility or previous failure treatments. Having an anxious partner was associated with anxious and depressive symptoms. For this reason, both males and females might benefit from psychological intervention, which could also help them to be supportive to each other. 相似文献207.
Anna Vanni Alessio Mazzoni Roberto Semeraro Manuela Capone Patrick Maschmeyer Giulia Lamacchia Lorenzo Salvati Alberto Carnasciali Parham Farahvachi Teresa Giani Gabriele Simonini Giovanni Filocamo Micol Romano Francesco Liotta Mir-Farzin Mashreghi Lorenzo Cosmi Rolando Cimaz Alberto Magi Laura Maggi Francesco Annunziato 《European journal of immunology》2023,53(7):2250162
208.
Antonio Brucato Micol Frassi Franco Franceschini Rolando Cimaz David Faden Maria Pia Pisoni Marina Muscar Gabriele Vignati Marco Stramba‐Badiale Luca Catelli Andrea Lojacono Ilaria Cavazzana Anna Ghirardello Francesca Vescovi Pier Franca Gambari Andrea Doria Pier Luigi Meroni Angela Tincani 《Arthritis \u0026amp; Rheumatology》2001,44(8):1832-1835
209.
210.
Alberto Rizzo Giacomo Pozza Federica Salari Andrea Giacomelli Davide Mileto Maria Vittoria Cossu Alessandro Mancon Gloria Gagliardi Bianchi Micol Valeria Micheli Amedeo Capetti Spinello Antinori Maria Rita Gismondo Pietro Olivieri Alessandra Lombardi 《Journal of medical virology》2023,95(1):e28328
In 2022, many monkeypox (MPX) outbreaks have been documented in countries where MPX was not endemic. It spread all around the world, especially in European Union and United States. While MPX is classically considered to be transmitted through close contact with lesions, the hypothesis of sexual transmission has been proposed. This study considered a total of 49 patients suspected for MPX that were also tested for other sexually transmitted infections (STIs), including Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, and Trichomonas vaginalis. The data from coinfected patients suggested that MPXV and STIs might share the same route of inoculum, corroborating the hypothesis of possible sexual transmission for the emerging poxvirus. And like any other STI, MPX should be considered without stigmatization. 相似文献