全文获取类型
收费全文 | 1609366篇 |
免费 | 128526篇 |
国内免费 | 4133篇 |
专业分类
耳鼻咽喉 | 20509篇 |
儿科学 | 51745篇 |
妇产科学 | 44835篇 |
基础医学 | 225676篇 |
口腔科学 | 41631篇 |
临床医学 | 146881篇 |
内科学 | 325803篇 |
皮肤病学 | 36222篇 |
神经病学 | 137407篇 |
特种医学 | 62619篇 |
外国民族医学 | 477篇 |
外科学 | 241539篇 |
综合类 | 34961篇 |
现状与发展 | 4篇 |
一般理论 | 655篇 |
预防医学 | 124446篇 |
眼科学 | 36380篇 |
药学 | 111988篇 |
2篇 | |
中国医学 | 3636篇 |
肿瘤学 | 94609篇 |
出版年
2021年 | 15250篇 |
2019年 | 15844篇 |
2018年 | 21630篇 |
2017年 | 16456篇 |
2016年 | 18408篇 |
2015年 | 20796篇 |
2014年 | 29600篇 |
2013年 | 43096篇 |
2012年 | 59936篇 |
2011年 | 63116篇 |
2010年 | 36745篇 |
2009年 | 34979篇 |
2008年 | 57857篇 |
2007年 | 61062篇 |
2006年 | 61300篇 |
2005年 | 59660篇 |
2004年 | 56786篇 |
2003年 | 53628篇 |
2002年 | 51628篇 |
2001年 | 74687篇 |
2000年 | 75763篇 |
1999年 | 63288篇 |
1998年 | 19373篇 |
1997年 | 17329篇 |
1996年 | 17214篇 |
1995年 | 16307篇 |
1994年 | 14752篇 |
1993年 | 13892篇 |
1992年 | 46691篇 |
1991年 | 44294篇 |
1990年 | 42154篇 |
1989年 | 40172篇 |
1988年 | 36760篇 |
1987年 | 35883篇 |
1986年 | 33419篇 |
1985年 | 31883篇 |
1984年 | 24606篇 |
1983年 | 20715篇 |
1982年 | 13114篇 |
1981年 | 11620篇 |
1979年 | 21122篇 |
1978年 | 15037篇 |
1977年 | 12482篇 |
1976年 | 11738篇 |
1975年 | 11904篇 |
1974年 | 14262篇 |
1973年 | 13773篇 |
1972年 | 12788篇 |
1971年 | 11612篇 |
1970年 | 11010篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
151.
The term “oligometastatic prostate cancer” refers to a heterogeneous group of disease states currently defined solely on the basis of clinical features. Oligorecurrent disease, de novo oligometastases, and oligoprogressive disease likely have unique biologic underpinnings and natural histories. Evidence suggesting the existence of a subset of patients who harbor prostate cancer with limited metastatic potential currently includes disparate and overwhelmingly retrospective reports. Nevertheless, emerging prospective data have corroborated the “better-than-expected,” retrospectively observed outcomes, particularly in the setting of oligorecurrent prostate cancer. Improved functional imaging with prostate-specific membrane antigen-targeted strategies may enhance the identification of patients with oligometastatic prostate cancer in the short term. In the long term, refinement of the oligometastatic case definition likely will require biologic risk-stratification schemes. To determine optimal treatment strategies and identify patients most likely to benefit from metastasis-directed therapy, future efforts should focus on conducting high-quality, prospective trials with much-needed molecular correlative studies. 相似文献
152.
M.‐Q. Man L. Ye L. Hu S. Jeong P. M. Elias C. Lv 《Clinical and experimental dermatology》2019,44(6):654-657
While therapeutic approaches for psoriasis are widely available, preventive regimens are lacking. We aimed to determine whether improvements in epidermal function could prevent psoriasis relapse. Two self‐controlled cohort studies were designed, enrolling two cohorts of patients with psoriasis (n = 30 and n = 60) to be treated topically with an in‐house‐prepared emollient or ATOPALM® cream applied twice daily to one forearm for 20 and 30 days, respectively, while the same sites on the contralateral arm served as the untreated control. Epidermal function on both arms was assessed prior to and at the end of the trials. Delayed relapse on the treated arm was seen in 54.5% and 71% of patients in the first and second cohort, respectively. The time of psoriatic relapse correlated with the extent of abnormalities in baseline epidermal function. These results suggest that improvements in epidermal function with topical emollients can prevent/attenuate the development of psoriasis. 相似文献
153.
154.
155.
156.
Leyi Wang Saraswathi Lanka Debbie Cassout Nohra E. Mateus‐Pinilla Ganwu Li William C. Wilson Dongwan Yoo Paul Shelton Richard L. Fredrickson 《Transboundary and Emerging Diseases》2019,66(5):1809-1820
First described in 1955 in New Jersey, epizootic haemorrhagic disease (EHD) causes a severe clinical disease in wild and domestic ruminants worldwide. Epizootic haemorrhagic disease outbreaks occur in deer populations each year from summer to late autumn. The etiological agent is EHD virus (EHDV) which is a double‐stranded segmented icosahedral RNA virus. EHD virus utilizes point mutations and reassortment strategies to maintain viral fitness during infection. In 2018, EHDV serotype 2 was predominantly detected in deer in Illinois. Whole genome sequencing was conducted for two 2018 EHDV2 isolates (IL41747 and IL42218) and the sequence analyses indicated that IL42218 was a reassortant between different serotypes whereas IL41747 was a genetically stable strain. Our data suggest that multiple strains contribute to outbreaks each year. 相似文献
157.
158.
Objectives:To reassess the long-term camouflage effects of resin infiltration (Icon, DMG, Hamburg, Germany) of white spot lesions (WSL) and sound adjacent enamel (SAE) achieved in a previous trial. The null hypothesis was tested that there were no significantly different CIE-L*a*b*-ΔE-values between WSL and SAE areas of assessment after at least 24 months (T24) compared to those at baseline (T0).Materials and Methods:Of twenty subjects who received previous resin infiltration treatment of nteeth = 111 nonrestored, noncavitated postorthodontic WSL after multibracket treatment during a randomized controlled trial and were contacted 20 months after baseline, eight subjects (trial teeth nteeth = 40; m/f ratio 1/7; age range (mean; SD) 12–17 [15.25; 2.12] years); response rate: 40%) were available for follow-up after at least 24 months (T24). CIE-L*a*b* differences between summarized color and lightness values (ΔEWSL/SAE) of WSL and SAE were assessed using a spectrophotometer and compared to baseline data assessed prior to infiltration (T0), and those after 6 (T6), and 12 (T12) months using paired t tests at a significance level of α = 5%.Results:T24 assessments were performed after a mean 33.86 (SD: 8.64; Min: 24; Max: 45) months following T0. Mean (SD) ΔEWSL/SAE units of available teeth were 8.76 (5.33) at baseline; 5.5 (2.75) at T6; 5.2 (2.41) at T12; and 5.57 (2.6) at T24. Comparisons of T6, T12, and T24 with T0 yielded highly significant differences, whereas T6–T24 and T12–T24 differences were found to be not significant.Conclusions:Assimilation of infiltrated WSL to the color of adjacent enamel by resin infiltration is considered to be suitable for the long-term improvement in the esthetic appearance of postorthodontic WSL. 相似文献
159.