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71.
Remiszewski P Słodkowska J Szczepek B Zwolska Z Radomski P Byszewska D Rowińska-Zakrzewska E 《Pneumonologia i alergologia polska》1999,67(7-8):354-361
In 116 out of 845 patients treated for small cell lung cancer (SCLC) in the Institute of Tuberculosis and Chest Disease in Warsaw in the years 1980-1994 infection was the main or coexistent cause of death. In 4.1% infection was proved of bacterial origin and in further 6.5% of probable bacterial origin (in the later group cultures were negative or not done but fungal infection, pneumocystosis pneumonia and tuberculosis were excluded on autopsy). In 1.54% infection was of fungal origin, 1.2% patients died of Pneumocystis carinii pneumonia and 0.35% of tuberculosis. The majority of patients who died with and/or from infection had treatment-related leukopenia and 99 of them were treated with corticosteroids. Fungal infection, pneumocytosis and tuberculosis were found more frequently than bacterial infection in patients treated with cumulative dose of prednisone above 2000 mg. 33.62% patients had no symptoms or signs of infection. No connection was found between the absence of symptoms and treatment with steroids or the grade of leukopenia. In all cases infection was recognised very late, in 58 only at autopsy. 相似文献
72.
U. Sławin´ska F. Tyc˘ S. Kasicki R. Navarrete G. Vrbová 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1998,120(2):193-201
After partial denervation, the remaining motor units (MUs) of adult fast extensor digitorum longus muscle (EDL) expand their
peripheral field. The time course of this event was studied using tension measurement and recordings of electromyographic
(EMG) activity. The results show that after section of the L4 spinal nerve, when only 5.3 ± 0.63 of the 40 MUs normally supplying
EDL muscle remain, the force of individual motor units starts to increase between the 1st and 2nd week after the operation
and continues to do so for a further week. The drastic reduction of the number of motoneurones supplying the fast EDL leads
to an increase in activity of the remaining MUs. In the 1st week after partial denervation, there was a sharp increase in
the EMG activity of remaining motor units. During the next 12 days, this increase became less marked, but EMG activity remained
nevertheless significantly higher than that of the unoperated EDL muscle. Many MUs became tonically active during posture.
The EMG activity pattern during locomotion was also altered, so that the burst duration was positively correlated with the
step cycle duration. Moreover, shortly after partial denervation, the interlimb coordination was disturbed but returned to
its original symmetrical use 1–2 weeks later.
Received: 17 September 1996 / Accepted: 3 November 1997 相似文献
73.
Kurzawski G Suchy J Kładny J Safranow K Jakubowska A Elsakov P Kucinskas V Gardovski J Irmejs A Sibul H Huzarski T Byrski T Debniak T Cybulski C Gronwald J Oszurek O Clark J Góźdź S Niepsuj S Słomski R Pławski A Łacka-Wojciechowska A Rozmiarek A Fiszer-Maliszewska Ł Bebenek M Sorokin D Stawicka M Godlewski D Richter P Brozek I Wysocka B Jawień A Banaszkiewicz Z Kowalczyk J Czudowska D Goretzki PE Moeslein G Lubiński J 《Journal of medical genetics》2002,39(10):e65
74.
Splenic metastasis from lung cancer is a rare clinical event, most often diagnosed at the time of an autopsy. We report a case of a 68 year old man with splenic metastasis from the primary lung cancer. Staging procedures before the resection of the primary lung tumor detected the splenic lesion. Upper left lobectomy and splenectomy were done by the left postero-lateral thoracotomy with phrenotomy. The rarity of solitary spleen metastasis from lung cancer and the treatment are discussed. 相似文献
75.
Krzyzak AT Jasiński A Weglarz WP Adamek D Sagnowskil P Baj M 《Acta neurobiologiae experimentalis》2005,65(3):255-264
Magnetic Resonance Diffusion Tensor Imaging (DTI) of the control and traumatic injured spinal cord of a rat in vitro is reported. Experiments were performed on excised spinal cords from 10 Wistar rats, using a home-built 6.4 T MR microscope. MRI and histopathological results were compared. Presented results show that DTI of the spinal cord, perfused with formalin 10 minutes after the injury, can detect changes in water diffusion in white matter (WM) and in gray matter (GM), in areas extending well beyond the region of direct impact. Histology of neurons of the GM shows changes that can be attributed to ischemia. This is in agreement with the observed decrease of diffusion in the injured regions, which may be attributed to the cytotoxic edema due to ischemia. However, the diffusion changes in highly anisotropic WM seem to be caused by a direct action of mechanical force of impact, which significantly distorts the nerve fibers. 相似文献
76.
Tellander AC Pettersson U Runström A Andersson M Michaëlsson E 《Journal of autoimmunity》2001,17(1):39-50
We have investigated interference with co-stimulation by administering mAbs towards CD28, CD80, CD86, and CD152 in mice immunized for the development of collagen-induced arthritis (CIA). Anti-CD80 and anti-CD86 treatment inhibited disease score and incidence, whereas anti-CD28 treatment led only to a delayed disease onset. Administration of anti-CD152 had no effect. The CII-specific Ab-response was suppressed by the co-stimulatory blockade, with a stronger effect on IgG1 than on IgG2a. The CII-driven T cell proliferation, on the other hand, was not affected. Furthermore, T cells primed in the presence of either anti-B7 or anti-CD28 produced markedly increased amounts of IFN-gamma in response to CII. To investigate whether this increase in IFN-gamma was related to disease suppression, IFN-gamma-deficient mice were immunized with CII, treated with anti-B7 and followed for the development of arthritis. As in the wild-type mice, administration of anti-B7 to IFN-gamma-deficient mice led to a reduced disease incidence and severity as well as reduced anti-CII IgG titers. Collectively, these data stress the importance of co-stimulation for the delivery of B cell help rather than for production of Th1 cytokines. We also demonstrate that the enhanced production of IFN-gamma observed after B7-blockade is not accountable for the anti-B7 mediated inhibition of CIA. 相似文献
77.
Alicja Gryczyńska-Siemiątkowska Alicja Siedlecka Joanna Stańczak Miłosława Barkowska 《Acta parasitologica / Witold Stefański Institute of Parasitology, Warszawa, Poland》2007,52(2):165-170
Sand lizards (Lacerta agilis) were trapped and examined for ticks from May to September in 2002 and 2003 in Northeastern Poland. A total of 233 Ixodes ricinus (L.) ticks (76 larvae and 157 nymphs) was found on 31 of 235 captured lizards (13.2%). The tick infestation is relatively
low compared to that of mammals and passerine birds from the same area (Siński et al. 2006, Gryczyńska et al. 2002). Tick infestation depended on the month of capture, being the highest in spring. In autumn no ticks were recorded on
any of the captured lizards. The oldest lizards carried the highest number of ticks but no differences related to sex of the
host were found. All the collected ticks were analysed by PCR for the presence of Borrelia burgdorferi sensu lato, the etiological agents of Lyme disease. Spirochetes were detected in 11 out of 233 (4.7%) ticks tested. Genetic
analysis confirmed that the spirochetes are members of the Borrelia afzelii, B. garinii and B. burgdorferi sensu stricto genospecies. Mixed infection were not detected. The prevalence of infection was analysed in relation to months
of the capture, age and sex of the lizards, but differences were not statistically significant. The obtained results suggest
that lizards are probably not B. burgdorferi reservoirs, but further studies are required to confirm this. 相似文献
78.
The aim of this study was to determine how glycosylation of the rat liver arylsulfatase B was influenced by the age of the animal. The enzyme was purified from a liver lysosomal fraction obtained from male Wistar rats aged 18 days of gestation, 1 week, and 1, 1.5, 3 and 18 months by an affinity chromatography. Examination of the carbohydrate structures was performed after electrophoresis and blotting, followed by a very sensitive detection system with a set of six highly specific digoxygenin-labelled lectins. After densitometric measurement of the intensity of a digoxigenin-labelled lectin binding to arylsulfatase B, it could be stated that, at least, changes in sialylation are related to the growth and development of rats. Sialylation increases while fucosylation slightly decreases with age of the animal. 相似文献
79.
E. Podsiadły J. Przyłuski A. Kwiatkowski M. Kruk M. Wszoła R. Nosek W. Rowiński W. Rużyłło S. Tylewska-Wierzbanowska 《European journal of clinical microbiology & infectious diseases》2005,24(8):507-513
Data published over the past decade show that Chlamydia pneumoniae is likely associated with the development of atherosclerosis. The aim of this study was to ascertain whether C. pneumoniae infections occur more frequently in patients with atherosclerosis than in healthy subjects. A total of 517 persons were studied. Serum samples, leukocytes, and tissue samples were assayed for the presence of C. pneumoniae-specific IgG and IgA antibodies and C. pneumoniae DNA. C. pneumoniae DNA was found in renal, iliac, and brachial vessels, but it was not detected in radial arteries. C. pneumoniae DNA was found most often in directional coronary atherectomy tissue specimens (11/41, 26.8%), but it was also found in the leukocytes of 14.9% (28/188) of patients with atherosclerosis and 24.6% (28/114) of patients without atheroma changes in vessels. Specific IgG and IgA antibodies were present in 63.8 and 49.9% of atheroma patients, respectively. The prevalence of C. pneumoniae antibodies differs significantly in patients with and without atherosclerosis (for IgG, p=0.002, and for IgA, p=0.006). The identification of persons with chlamydial infection of atherosclerotic arteries necessitates the examination of vascular tissues obtained during revascularization procedures. Serological investigation alone cannot identify individuals with vascular chlamydial infections. Detection of C. pneumoniae DNA in peripheral blood mononuclear cells does not seem to be the exclusive marker of persistent vascular infection. A more easily accessible parameter that allows prediction of chlamydial vascular infection is required. 相似文献
80.
Marcinkiewicz J Biedroń R Maresz K Kwaśny-Krochin B Bobek M Kontny E Maśliński W Chain B 《Archivum immunologiae et therapiae experimentalis》2004,52(4):284-291
INTRODUCTION: Oxidative modification of proteins affects their biological properties. Previously we have shown that hypochlorite (HOCl), the product of activated neutrophils, enhances protein immunogenecity. Collagen type II, a primary component of cartilage, is commonly used in the induction of arthritis in animals (CIA). The aim of this study was to examine whether HOCl may affect immunogenic, tolerogenic, and arthritogenic properties of collagen. MATERIALS AND METHODS: DBA/J mice were injected with either native (CNAT) or chlorinated collagen (CHOCl) to induce arthritis. The effect of chlorination on collagen properties was measured by evaluation of incidence and severity of CIA. Moreover, the concentration of serum anti-collagen IgG antibodies and myeloperoxidase (MPO) activity in inflamed joints was determined. RESULTS: Mice immunized with CNAT in adjuvant developed arthritis (CIA) with an incidence of 69%. CNAT also exerted tolerogenic properties when injected intravenously either before or shortly after primary immunization, resulting in decreased incidence and severity of CIA, reduced MPO activity in inflamed joints, and lowered serum levels of anti-CNAT IgG anti-bodies. Chlorination of collagen significantly diminished its ability to induce CIA and to trigger generation of anti-CNAT IgG antibodies. Interestingly, chlorination did not affect tolerogenic properties of collagen administered prior to primary immunization with CNAT. CONCLUSIONS: These results suggest that chlorination of collagen may selectively affect functional epitopes of collagen. It is likely that in inflamed joints, neutrophil derived HOCl, in some circumstances, will destroy arthritogenic and immunogenic B cell epitopes, while regulatory T cell epitopes will be preserved. 相似文献