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101.
Mohammad Mahmoud AlKot Mahmoud Tawfik KhalafAllah Mohamed Salah Zahran Mostafa Mohamed Kallaf Ahmed Medhat Zayed 《Teaching and learning in medicine》2015,27(3):264-273
Phenomenon: Attitudes of medical students toward family medicine as a specialty choice can provide information on the future supply of family physicians. Due to the current worldwide shortage of family physicians, these attitudes, with their subsequent effects on the state and dynamics of the healthcare system, are important to investigate. Approach: A web-based questionnaire was sent to 600 medical students, selected by a systematic random sampling technique, in 7 Egyptian medical schools. Participants were surveyed to assess their perception of the family medicine specialty as a future career and explore the impact of different factors, including undergraduate family medicine clerkships, on their attitudes toward family medicine. Findings: We had a response rate of 75.2% (n = 451). Although 90.7% of students believed in the vital role that family medicine can play in Egypt's healthcare system, only 4.7% showed an intention to choose it as a future career. Students choosing family medicine as a first-career choice were more likely to have a prior contact with family physicians as consumers. Exposure to an undergraduate family medicine curriculum was associated with increased knowledge about family medicine but not the intentions to pursue it as a career. Insights: Medical students in Egypt have a positive perception of family medicine as an important specialty but low interest in its choice as a future career. 相似文献
102.
Afifi Abd EL- Moaty Ali Shaat Reham Magdy Gharbia OLa M. Boghdadi Yosra EL Eshmawy Mervat Mohammad EL El-Emam Ola Ali 《Clinical rheumatology》2018,37(10):2855-2861
Clinical Rheumatology - Pathogenesis of osteoarthritis may have a systemic metabolic component. This study was undertaken to assess the prevalence of primary knee osteoarthritis (OA) in a sample of... 相似文献
103.
Fayed Ahmed Soliman Ahmed Naguib Mervat Soliman Mahmoud Salaheldin M. 《International urology and nephrology》2019,51(4):737-743
International Urology and Nephrology - Women with chronic kidney disease commonly have menstrual irregularities and fertility abnormalities. Antimüllerian hormone (AMH) and antral follicle... 相似文献
104.
Amani Al-Rawashdeh Violet Kasabri Nailya Bulatova Amal Akour Ayman Zayed Munther Momani Nahla Khawaja Haider Bustanji Dana Hyasat 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2017,11(1):59-67
Background
Oxytocin (OXT) is a neurohypophyseal hormone that has been recently shown to possess a number of beneficial effects in diabetes and obesity. Betatrophin is a protein expressed in fat and liver that regulates lipid metabolism and promotes pancreatic β-cell proliferation. It is not investigated yet whether OXT and betatrophin levels correlate in metabolic syndrome (MS) or diabetes patients.Methods
The aim was to assess correlations between plasma betatrophin and OXT levels in MS-diabetic or prediabetic (N = 89) as compared to MS-non-diabetic (N = 69) patients. Competitive binding ELISA was used to evaluate betatrophin and OXT plasma concentrations. Correlations of the above biomarkers and patient clinical characteristics were also detected.Results
As compared to the control MS participants (0.32 ± 0.25 ng/mL); betatrophin plasma levels were increased (P < 0.001) in the MS-pre/T2DM patients (1.23 ± 0.68 ng/mL). On the contrary, OXT concentrations were decreased (P < 0.001) in the MS-pre/T2DM patients (1222.46 ± 514.55 pg/mL) as compared to the MS control subjects (2323.42 ± 848.68 pg/mL). OXT concentration correlated negatively (r = ?0.492, P < 0.001), while HbA1c and FPG correlated positively with betatrophin plasma levels (P < 0.001), but were inversely correlated with OXT levels (P < 0.001) in the total sample.Conclusion
Betatrophin levels are increased, while OXT levels are decreased in MS-pre/T2DM. We found an inverse correlation between the levels of the two biomarkers in addition to correlation between their levels and the degree of glycemic control. 相似文献105.
Abrus agglutinin promotes irreparable DNA damage by triggering ROS generation followed by ATM‐p73 mediated apoptosis in oral squamous cell carcinoma 下载免费PDF全文
106.
Zayed H Effat D Nawito Z Abdou AA El Din MN El-Refaei S Amin M Mohamed Y Amin A Wafie A Abu El-Einin K 《Clinical rheumatology》2011,30(9):1173-1180
Beh?et's disease (BD) is an idiopathic multisystem disorder. Involvement of CNS occurs in 4-48% of cases. This study was designed to evaluate the prevalence of subclinical neuropsychiatric affection in asymptomatic Egyptian BD patients using psychometric tests and brain imaging with single photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI), also to assess possibly associated clinical predictive variables. Twenty-five BD patients without overt CNS involvement and ten healthy controls matched for age, education, and sex completed a comprehensive neuropsychological battery including Hamilton scales for anxiety and depression and Wechsler memory scale-revised. Disease activity was assessed using Beh?et's Disease Current Activity Form (BDCAF). SPECT was done for all subjects, and 12 patients underwent brain MRI. Compared to controls, 23 (92%) and 24 (96%) patients had anxiety and depression scores respectively above normal range; also, BD patients had significantly lower memory quotient (MQ). SPECT revealed abnormalities in 16/25 (64%), while in 3/12 patients (25%), MRI was abnormal. Subjects with abnormal SPECT had significantly higher ages than those with normal SPECT (P?=?0.02) and were more frequently males (P?=?0.03). No statistically significant differences between cases with normal or abnormal SPECT were found regarding disease duration, frequency of headache, BDCAF, frequency of active eye disease, major vascular involvement, mean Hamilton anxiety and depression scores, and mean MQ. Early diagnosis of neurological involvement in BD is important in reducing or preventing complications. Neuropsychiatric evaluation and HMPAO brain SPECT were found to be useful for detecting subclinical neurological abnormalities in BD patients. 相似文献
107.
Rania Samir Osama A. Diab Ayman Morttada Mervat Aboulmaaty 《The Egyptian Heart Journal》2011,63(3-4):183-189
BackgroundPermanent pacing in pediatric population has been growing in Egypt. The aim of this study is to present one center experience in pediatric pacing including implantation procedures and long-term outcome.Methods and resultsDuring the period from 1996 to 2010, we collected the data of 32 children (18 males) with a mean age of 5.7 ± 3.8 years that underwent permanent pacemaker (PPM) implantation. Their mean weight was 21.6 ± 13.8 kg, and median body surface area (BSA) was 0.7 m2. Twenty-five patients (78.1%) had congenital heart disease (CHD). Pacing was done via subclavian vein puncture while epicardial pacing was done via standard surgical techniques. All patients were followed up for 0.25–14 years (median: 2.5 years). Suboptimal pacing parameters were defined by one or more of the following: R/P wave malsensing, pacing threshold >2 V, or battery longevity of <1 year. The first PPM was endocardial in 21 patients (65.6%) and epicardial in 11 patients (34.4%). VVI PPMs were implanted in 8 cases (25%), VVIR in 20 cases (62.5%) and DDD in 4 cases (12.5%). A total of 46 procedures were done during the period of study, and total of 44 pulse generators and 46 leads (31 endocardial) were implanted. Fourteen patients (43.7%) required 2nd ± 3rd procedures. During follow up, suboptimal pacing parameters or pacing system failure were reported in 12 patients (37.5%) who had significantly lower age, weight and BSA (P = 0.048, 0.023, and 0.032, respectively). The overall battery survival was 60% at 125 months, and ventricular lead survival was 63% at 125 months, with no significant difference in survival between epicardial and endocardial leads (P > 0.05).ConclusionPermanent pacing in pediatric age group is relatively safe. However, there is substantial higher incidence of suboptimal pacing parameters and pacing system failures especially in younger and smaller children. Epicardial steroid eluting leads are comparable to endocardial steroid eluting leads in performance. 相似文献
108.
Wade WJ Alhussainan TS Al Zayed Z Hamdi N Bubshait D 《Journal of children's orthopaedics》2010,4(5):429-438
Background
Pericapsular acetabuloplasty procedures have been widely used as an integral component of combined surgery to treat developmental hip dislocation after walking age. The stability of the acetabuloplasty and the maintenance of the acetabular correction will depend on the structural integrity of the iliac crest autograft, which, traditionally, has been inserted as the interposition material. Problems related to the use of an autograft have been encountered by various surgeons—including the authors—namely, graft displacement and resorption, which may necessitate internal fixation or result in revision surgery. To overcome autograft failure, the use of an allograft as the interposition material has been introduced by some surgeons. This study describes the radiologic results of 147 hips treated for developmental hip dislocation by means of a standard protocol of open hip reduction and pericapsular acetabuloplasty with a contoured iliac crest allograft as the interposition material. 相似文献109.
Synthesis,Characterization, and Evaluation of Cytotoxic Effects of Novel Hybrid Steroidal Heterocycles as PEG Based Nanoparticles 下载免费PDF全文
Mervat M Abd ElhaliemNasser S M IsmailShaymaa M M YahyaYasmin Y OmarAhmed A Abd RabouDeena S LasheenMahmoud F ZawrahGamal A Elmegeed 《Asian Pacific journal of cancer prevention》2017,18(7):1937-1946
Anticancer agents featuring hybrid molecules can improve effectiveness and diminish drug resistance. The current study aimed to introduce newly synthesized heterocyclic steroids of promising anticancer effects loaded in polyethylene glycol (PEG)•based nanoparticles form. Several heterocyclic steroids (1-9) were synthesized via multicomponent reactions (MCRs) and confirmed via the analytical and spectral data. Compounds 1, 2, 3, 4, 5, 6, 7 and 9, were investigated individually in their free and PEG based nano-size hybrid forms as anticancer agents against three human cell lines: hepatocellular carcinoma cells (HepG2); breast cancer cells (MCF-7); and colon cancer cells (HCT116). The neutral red supravital dye uptake assay was employed. Compound 6 in its PEG based nano-size form exhibited the best cytotoxic effects against HepG2 and HCT116 cell lines, with IC50 values of 2.44 μmol/l and 2.59 μmol/l, respectively. In addition, it demonstrated a low IC50 value against MCF-7 (3.46μmol/l) cells. This study introduced promising anticancer agents acting through conversion into PEG-based nanoparticles. 相似文献
110.
Ashraf Abd El-Khalik Barakat Fatma Mohammad Nasr Amna Ahmed Metwaly Sherif Morsy Mervat Eldamarawy 《The Egyptian Heart Journal》2017,69(2):139-147