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41.
M. Gietzelt J. Spehr Y. Ehmen S. Wegel F. Feldwieser M. Meis M. Marschollek K.-H. Wolf E. Steinhagen-Thiessen M. G?vercin 《Zeitschrift für Gerontologie und Geriatrie》2012,45(8):716-721
Background
A considerable proportion of falls occur within the domestic environment. Sensor-based identification of falls in seniors?? homes could help them to remain autonomous and self-sufficient in their own homes. The objective of this study was to evaluate fall detection systems within the home environment using optical and accelerometric sensor systems.Methods
Portable triaxial accelerometers and optical sensors were used to detect falls in subjects with known problems of mobility and a recent fall history.Results
Three subjects were investigated with the system. Overall nine falls occurred during the study period. Four falls were recorded by the accelerometric system and one fall by the optical system. Subjects with increased risk of falling as measured with mobility and fall risk assessments tend to fall more frequently.Conclusion
The study shows that there is a considerably large difference between fall-detector evaluation studies in domestic environments and in laboratory trials. 相似文献42.
In this case, a male patient presented with a clinically and radiographieally unstable slipped capital femoral epiphysis (SCFE) as well as slipped calcaneal epiphysis years. Subsequent thorough at the age of 23 work-up revealed that he had some features of rickets and labo- ratory test demonstrated he had hypophos- phatemia (2.3mg/dl), normocalcemia, normal vi- tamin D metabolite levels, and secondary hy- perparathyroidism. 相似文献
43.
Jane E Sarginson JF William Deakin Ian M Anderson Darragh Downey Emma Thomas Rebecca Elliott Gabriella Juhasz 《Neuropsychopharmacology》2014,39(12):2857-2866
There is increasing evidence that genetic factors have a role in differential susceptibility to depression in response to severe or chronic adversity. Studies in animals suggest that nitric oxide (NO) signalling has a key role in depression-like behavioural responses to stress. This study investigated whether genetic variation in the brain-expressed nitric oxide synthase gene NOS1 modifies the relationship between psychosocial stress and current depression score. We recruited a population sample of 1222 individuals who provided DNA and questionnaire data on symptoms and stress. Scores on the List of Life-Threatening Experiences (LTE) questionnaire for the last year and self-rated current financial hardship were used as measures of recent/ongoing psychosocial stress. Twenty SNPs were genotyped. Significant associations between eight NOS1 SNPs, comprising two regional haplotypes, and current depression score were identified that survived correction for multiple testing when current financial hardship was used as the interaction term. A smaller three-SNP haplotypes (rs10507279, rs1004356 and rs3782218) located in a regulatory region of NOS1 showed one of the strongest effects, with the A-C-T haplotype associating with higher depression scores at low adversity levels but lower depression scores at higher adversity levels (p=2.3E-05). These results suggest that NOS1 SNPs interact with exposure to economic and psychosocial stressors to alter individual''s susceptibility to depression. 相似文献
44.
Yves?JF?GarinEmail author Pascale?Meneceur Francine?Pratlong Jean-Pierre?Dedet Francis?Derouin Frédéric?Lorenzo 《BMC infectious diseases》2005,5(1):18
Background
Leishmaniases are among the most proteiform parasitic infections in humans ranging from unapparent to cutaneous, mucocutaneous or visceral diseases. The various clinical issues depend on complex and still poorly understood mechanisms where both host and parasite factors are interacting. Among the candidate factors of parasite virulence are the A2 genes, a family of multiple genes that are developmentally expressed in species of the Leishmania donovani group responsible for visceral diseases (VL). By contrast, in L. major determining cutaneous infections (CL) we showed that A2 genes are present in a truncated form only. Furthermore, the A2 genomic sequences of L. major were considered subsequently to represent non-expressed pseudogenes [1]. Consequently, it was suggested that the structural and functional properties of A2 genes could play a role in the differential tropism of CL and VL leishmanias. On this basis, it was of importance to determine whether the observed structural/functional particularities of the L. major A2 genes were shared by other CL Leishmania, therefore representing a proper characteristic of CL A2 genes as opposed to those of VL isolates. 相似文献45.
Platelet-melanoma cell interaction is mediated by the glycoprotein IIb- IIIa complex 总被引:3,自引:0,他引:3
A human malignant melanoma cell line (M3Dau) was observed by electron microscopy to interact directly with human platelets and induced platelet aggregation. Fab fragments of a monoclonal antibody MoAb (LYP18), directed against the platelet glycoprotein (GP) IIb-IIIa complex, inhibited platelet-melanoma interactions and platelet-platelet aggregation. M3Dau melanoma cells bind LYP 18 and synthesize IIb-IIIa- like GPs. When the melanoma cells were preincubated with LYP 18, tumor- platelet interaction did not occur, suggesting that the interaction may be mediated by the IIb-IIIa-like GPs present on the melanoma cell surface. Glanzmann's thrombasthenic platelets, lacking GPIIb and IIIa, did not interact with melanoma cells, indicating that the platelet GPIIb-IIIa complex is also necessary for the platelet-melanoma cell interaction. This work demonstrates the importance of the IIb-IIIa-like GPs, present on M3Dau melanoma cells, in mediating tumor-platelet interactions. 相似文献
46.
J. F. G. M. Meis M. D. Ph. D. Prof. J. A. A. Hoogkamp-Korstanje M. D. Ph. D. T. W. Polder M. D. Ph. D. P. van de Kar M. D. 《Infection》1993,21(3):174-176
Summary A case ofFusobacterium necrophorum bacteremia and multiple brain abscesses in a 6-year-old child following aMycoplasma pneumoniae infection is described. Brain abscess due to this microorganism has only been described in three other cases since 1977. The clinical picture was consistent with postanginal septicemia, with septic metastatic complications normally only seen in teenagers and young adults. The patient was successfully treated with a 2-month course of parenteral penicillin G and metronidazole.
Multiple Hirnabszesse und Bakteriämie durch Fusobacterium necrophorum bei einem Kind
Zusammenfassung Eine Bakteriämie, kompliziert durch multiple Hirnabszesse, trat bei einem sechs Jahre alten Kind nach einer Atemwegsinfektion durchMycoplasma pneumoniae auf. Seit 1977 wurden nur drei Fälle von Hirnabszeß durchF. necrophorum beschrieben. Das klinische Bild war vergleichbar mit einer postanginösen Bakteriämie mit septischer Komplikation, wie sie normalerweise bei jungen Erwachsenen gefunden wird. Die parenterale Behandlung mit Penicillin-G und Metronidazol für zwei Monate führte zur Heilung.相似文献
47.
J. F. G. M. Meis M. D. Ph. D. A. M. Horrevorts M. D. Ph. D. J. M. D. Galama M. D. Ph. D. C. R. M. Weemaes M. D. Ph. D. S. J. Aerdts M. D. Ph. D. P. J. Westenend M.D. 《Infection》1992,20(5):287-289
Summary Acute Q-fever is a systemic illness which rarely has a fatal outcome. Fatal cases do occur with the chronic form of the disease and associated with endocarditis. This report presents the case of a fatal, acute Q-fever pneumonia in an 11-year-old patient with chronic granulomatous disease. Complement fixation antibody titer rose to 1:1,024 with positive IgM in immunofluorescence. Giemsa stained lung sections and indirect immunofluorescence demonstrated the microorganisms in the tissues. TheCoxiella burnetii infection was probably contracted during a holiday trip to rural France. Despite the fact that the patient received a variety of antimicrobial agents with broad spectrum activity against bacteria and fungi, coverage for Q-fever, i.e. chloramphenicol or tetracyclines, was not included.
Rascher tödlicher Verlauf einer Q-Fieber-Pneumonie bei einem Patienten mit chronischer Granulomatose
Zusammenfassung Akutes Q-Fieber ist eine systemische Krankheit, die nur selten tödlich endet — etwa bei chronisch Kranken oder bei Auftreten einer Endokarditis. Im vorliegenden Fall führte eine akute Q-Fieber-Pneumonie, die bei einem 11jährigen Kind mit chronischer Granulomatose auftrat, zum Tod. Die Komplementbindungsreaktion zeigte einen Antikörpertiteranstieg auf 1:1,024. IgM war im Immunofluoreszenztest nachzuweisen. Der Erreger wurde in histologischen Schnitten in der Lunge nach Giemsa-Färbung und mittels indirekter Immunfluoreszenz nachgewiesen. Das Kind hatte sich wahrscheinlich während eines Urlaubs in Frankreich mitCoxiella burnetii infiziert. Die Behandlung erfolgte mit einer Vielzahl antimikrobieller Substanzen mit breitem Wirkungsspektrum, Substanzen mit Aktivität gegen Q-Fieber wie Chloramphenicol oder Tetrazykline wurden jedoch nicht eingesetzt.相似文献
48.
Metabolic activity of phagocytosing granulocytes in chronic granulocytic leukemia: ultrastructural observation of a degranulation defect 总被引:4,自引:0,他引:4
Cramer E; Auclair C; Hakim J; Feliu E; Boucherot J; Troube H; Bernard JF; Bergogne E; Boivin P 《Blood》1977,50(1):93-106
The functional capacities of granulocytes in patients with chronic granulocytic leukemia are still a subject of controversy, probably due to the heterogeneity of the abnormalities observed from patient to patient. For a better definition of these abnormalities, 14 patients with untreated chronic granulocytic leukemia were studied. The patients were divided into three groups on the basis of the functional activities of their phagocytosing granulocytes. In four patients (group I), the granulocytes were normal in respect to particle ingestion, nitroblue tetrazolium (NBT)-stimulated reduction, cyanide-insensitive oxygen (O2) consumption, superoxide anion (O2-)-stimulated production, hydrogen peroxide (H2O2) production, and iodination. They also had a normal myeloperoxidase (MPO) content. In four patients (group III), the granulocytes were significantly defective in all of these activities. In the six remaining patients (group II), all the initial metabolic steps of the phagocytosing granulocytes (ingestion, NBT reduction, O2 consumption, O2-production, H2O2 production) were normal, as were the MPO content of the granulocytes, while iodination was strikingly decreased. These metabolic features suggested a degranulation defect which was observed ultrastructurally in the only patient studied among these six. The phagocytosing granulocytes of this patient did not degranulate and no deposits of MPO activity were seen in the phagosomes. 相似文献
49.
50.
TCR gamma delta bearing lymphocyte clones with lymphokine-activated killer activity against autologous leukemic cells 总被引:1,自引:0,他引:1
Activated T lymphocytes with the T-cell receptor (TCR) gamma delta (CD3+ and TCR delta 1+) exhibit strong cytotoxic activity against the standard natural killer (NK) and lymphokine-activated killer (LAK) sensitive target cells. In order to test the cytotoxic activity of gamma delta T lymphocytes against autologous leukemic cells, 84 clones of gamma delta T lymphocytes were obtained from the peripheral blood of three acute lymphoblastic leukemia (ALL) patients. Forty-four of these T-cell clones were active against an LAK-sensitive cell line and the other 40 were active against K562, an NK target cell line. In each of the three patients, cytotoxic clones against autologous leukemic cells were obtained. Among the 84 clones, ten were able to kill autologous tumor cells, including eight that lyse the LAK-sensitive target and two with NK activity. The clones were highly cytotoxic, stable, and easily expanded in large quantity. 相似文献