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951.
Onen A Cigdem MK Deveci E Kaya S Turhanoğlu S Yaldiz M 《Journal of pediatric surgery》2003,38(11):1642-1649
Purpose:
The aim of this study was to determine the effects of whole blood, crystalloid, and colloid treatment on histopathologic damage of kidney induced by hemorrhagic shock in rats.Methods:
Fifty-six male Sprague Dawley rats were divided into 8 groups. The carotid artery was cannulated, and systolic arterial pressure (SAP), diastolic arterial pressure (DAP), heart rate (HR), and rectal temperature (RT) were observed during the procedure. The jugular vein also was cannulated, and the SAP was decreased by aspiration of 75% of blood through the jugular vein in the control (nonresuscitated) and study (resuscitated) groups, whereas blood was not diminished in the sham group. The hemorrhagic shock was permitted to last 45 minutes; then, the study group rats were resuscitated with heparinized shed autologous whole blood (WB), normal saline (NS), Lactated Ringer’s solution (LR), hydroxyethyl starch 6% (HES6), hydroxyethyl starch 10% (HES10), or dextran 40 (D40). Histopathologic evaluation was performed under light and electron microscope.Results:
The RT, SAP, and DAP decreased, and HR increased significantly in the control and study groups during the shock period compared with those of sham group. After volume resuscitation, these parameters changed to preshock levels. Electron and light microscopic examinations of kidneys showed severe proximal tubular degeneration with moderate glomerular damage in the control group; moderate proximal tubular degeneration with mild glomerular damage in the NS, LR, HES6, and HES10 groups; and mild proximal tubular degeneration with no evidence of glomerular damage in the WB and D-40 groups.Conclusions:
The characteristic ultrastructural features of hemorrhagic shock appear to be severe tubular degeneration and mild to moderate changes in glomeruli. Resuscitation of hemorrhagic shock with whole blood or dextran 40 solution appears to be most favorable therapy in preventing ultrastructural renal damage in rats. 相似文献952.
Intravenous magnesium sulfate prophylaxis for atrial fibrillation after coronary artery bypass surgery 总被引:4,自引:0,他引:4
Kaplan M Kut MS Icer UA Demirtas MM 《The Journal of thoracic and cardiovascular surgery》2003,125(2):344-352
OBJECTIVE: Atrial fibrillation is a rhythm disorder commonly seen early after coronary artery bypass grafting, and it increases morbidity. METHODS: To investigate the effectiveness of magnesium sulfate in the prophylaxis of atrial fibrillation, we conducted a prospective, randomized, placebo-controlled clinical study on 200 consecutive patients in whom we performed elective and initial coronary artery bypass grafting operations. In each group 50% of patients underwent beating-heart operations. In the treatment group 100 patients (76 men and 24 women; mean age, 57.63 +/- 9.68 years) received 24.34 mEq (3 g) of magnesium sulfate in 100 mL of saline solution that was administered over 2 hours (50 mL/h) preoperatively, perioperatively, and at postoperative days 0, 1, 2, and 3. In the control group 100 patients (74 men and 26 women; mean age, 59.96 +/- 9.29 years) received only 100 mL of saline solution according to the same administration schedule as the treatment group. RESULTS: Atrial fibrillation developed in 15 patients from the treatment group and in 16 patients from the control group. The arrhythmia developed after 37.87 +/- 12.76 and 45.26 +/- 15.27 hours in the treatment and control groups, respectively. Although a significant relationship was found between low magnesium sulfate levels and increased incidence of atrial fibrillation (P <.05), when the incidence of postoperative atrial fibrillation is concerned, no significant difference was found between the 2 groups (P >.05). Also, no significant difference was found between operations with cardiopulmonary bypass and beating-heart operations in terms of atrial fibrillation incidence (P >.05). However, atrial fibrillation extended the duration of hospital stay in both groups (P <.05). CONCLUSION: Our findings indicate that magnesium sulfate infusion alone is not sufficient for the prophylaxis of atrial fibrillation. 相似文献
953.
Köksal IT Usta M Erdoğru T Ateş M Kukul E Baykara M 《International urology and nephrology》2003,35(2):227-229
Posterior urethral valves are usually detected during infancy by prenatal sonography. Less is known about presentation and outcome in older patients. We are describing a patient who presented with renal stones and was found incidentally on cystoscopy to have Type I urethral valves. 相似文献
954.
In hips with acetabular dysplasia, we performed Kotz osteotomy (group 1) in 22 hips (20 patients; mean age 24.3 years) and Ganz osteotomy (group 2) in 23 hips (22 patients; mean age 23.1 years). Group 1 was followed 83.3 (56-112) months and group 2 40.9 (24-66) months. In group 1, Harris hip score improved from average 74.9 to 86.9, mean center edge (CE) angle from -4.5 degrees to 30.3 degrees, and mean vertical center edge (VCE) angle from 5.3 degrees to 36.2 degrees. In group 2, Harris hip score improved from average 76.6 to 91.1, mean CE angle from -5.9 degrees to 32.0 degrees, and mean VCE angle from 5.0 degrees to 41.3 degrees. Using Pauwels criteria, regression was observed in 12 hips in group 1 and one progressed. In group 2, 15 hips showed regression and three progressed. In patients treated with Ganz osteotomy, the complication rate was higher and the complications more serious than in patients treated with Kotz osteotomy. Most complications were, however, seen among the first ten patients treated with Ganz osteotomy. Although we detected no significant difference between the two groups in terms of clinical and radiological findings, we believe the outcome to be slightly better after a properly performed Ganz osteotomy. 相似文献
955.
Morphometry of the anterior third ventricle region as a guide for the subfrontal (translaminaterminalis) approach 总被引:1,自引:0,他引:1
The anterior third ventricle region acquires clinical significance in benign and malignant tumors and cyst formations, of
which craniopharyngiomas and gliomas are the most common. The subfrontal approach is one of the most preferred approaches
for removing these tumors. In this study, the microsurgical anatomy of 81 Turkish, adult cadaveric hemispheres was examined
to provide morphometric data of the region. These measurements from the anterior third ventricle region serve as a guide for
neurosurgeons during surgical approach for removing anterior third ventricle tumors. 相似文献
956.
957.
The relation between tooth loss and bone mass in postmenopausal osteoporotic women in Turkey: a multicenter study 总被引:3,自引:0,他引:3
Gur A Nas K Kayhan O Atay MB Akyuz G Sindal D Akşit R Oncel S Dilsen G Cevik R Gunduz OH Ersoy Y Altay Z Ozturk C Akkus S Senocak O Kavuncu V Kirnap M Tekeoglu I Erdogan F Sarac AJ Demiralp L Demirkesen A Adam M 《Journal of bone and mineral metabolism》2003,21(1):43-47
The purpose of this study was to investigate the associations of tooth loss with skeletal bone mass, years since menopause,
educational level, current smoking status, dietary calcium intake, and number of pregnancies in postmenopausal osteoporotic
women in Turkey. The study population consisted of 1171 postmenopausal women aged 40–86 years (mean age, 61.19 ± 7.28 years).
A detailed history was obtained from all women, including relevant lifestyle parameters, risk factors, and measurements of
weight and height. Women were separated into three groups according to the number of teeth remaining as group 1 (edentulous,
457 women), group 2 (10 or fewer teeth, 232 women), and group 3 (more than 10 teeth remaining, 482 women). There was no significant
difference among the three groups in mean age and menopausal age (P < 0.05). Body mass index of group 1 was significantly higher than that of group 2 (P < 0.01). Educational level was significantly different between three groups: groups 1 and 2 (P < 0.001), groups 1 and 3 (P < 0.0001), and groups 2 and 3 (P < 0.001). Educational level was lowest in group 1 and highest in group 3. Despite a low ratio of cigarette smoking in general,
a smoking habit was most prevalent in group 3 and least in group 2. The ratio of women receiving adequate calcium was significantly
lower in group 1 than in other groups (P < 0.001); mean calcium intake was similar in all groups. The number of pregnancies was significantly higher in group 1 than
in other groups (P < 0.001). Lumbar bone mineral density (BMD) of group 1 was significantly lower than that of groups 2 and 3 (P < 0.001). Although no significant difference was found between groups 1 and 3, femoral neck BMD of group 2 was less than in
others, and differences between groups 1 and 2 and between groups 2 and 3 (P < 0.001) were significant. Lumbar bone mineral content (BMC) of group 1 was significantly lower than that of groups 2 and
3 (P < 0.001), and lumbar BMC in group 2 was significantly higher than in group 3 (P < 0.05). Femoral neck BMC in group 1 was significantly higher than in groups 2 and 3 (P < 0.001). In conclusion, lumbar BMD and BMC in the edentulous group were significantly lower, whereas femoral neck BMD and
BMC were significantly higher in edentulous group compared with the others. Our findings indicated that improvement in lifestyle
factors and nutritional strategies for the treatment and prevention of osteoporosis may have additional benefit in reducing
tooth loss.
Received: February 18, 2002 / Accepted: June 21, 2002
Offprint requests to: A. Gur 相似文献
958.
Influence of number of pregnancies on bone mineral density in postmenopausal women of different age groups 总被引:7,自引:0,他引:7
Gur A Nas K Cevik R Sarac AJ Ataoglu S Karakoc M 《Journal of bone and mineral metabolism》2003,21(4):234-241
As data on the relationship between parity and bone mineral density often seem to be controversial, ultimately, a comprehensive
research study was thought to be necessary. This study focused on examining the influence of the number of pregnancies on
bone mineral density and investigating the relationship between pregnancy and bone mineral density at four sites in postmenopausal
women of different age groups. A total of 509 postmenopausal women, varying from 45 to 86 years of age (mean age of 60.85
± 7.53 years) were considered for the study. A standardized interview was employed to obtain information on demographics,
lifestyle, and, reproductive and menstrual histories. Patients were separated into four groups according to the number of
pregnancies, i.e., nulliparae (52 patients), one to two parity (66 patients), three to five parity (178 patients), and more
than five parity (213 patients). The patients were further classified into two age groups, 40–59 years (233 patients) and
60–80 years (276 patients), respectively. The number of pregnancies was found to range from 0 to 17 (with an overall mean
of 5.42 ± 3.68), with 4.29 ± 2.74 (range, 0–16) accounting for live births, while 1.02 ± 1.53 (range, 0–14) were abortions.
There were no significant differences among the groups with respect to parameters such as, age, body mass index (BMI), age
at menarche, age at menopause, and years since menopause (P > 0.05) in all of the 509 women and in the 40- to 59- and 60- to 80-year groups. When all the patients were considered, the
bone mineral density (BMD) values of the spine and the trochanter for the more-than-five-parity group, were found to be significantly
lower than those of the other groups (P < 0.05), while the BMD values of the spine and the femur (neck, trochanter) appeared to decrease with increasing parity.
In the 40- to 59-year group, the BMD of the spine in both the nulliparae and one-to-two-parity groups was significantly higher
than that of the more-than-five-parity group (P < 0.05). No significant differences were found among the groups with respect to the BMD values at any femur sites. The nulliparae
patients in the 60- to 80-year group exhibited significantly higher trochanter and Ward's BMD values than those of the more-than-five-parity
group (P < 0.05), whereas in the one-to-two-parity group, spine BMD values appeared to be significantly higher than those of the more-than-five-parity
group (p < 0.05). Significant correlations were found between the number of pregnancies and BMD values for the spine (r = −0.23; P < 0.01), trochanter (r = −0.16; P < 0.01), and Ward's triangle (r = −0.14; P < 0.05), with no significant correlation for femur neck BMD (r = −0.08; P > 0.05) values. In conclusion, the present study suggests that the number of pregnancies has an effect on the BMD values
and that this situation shows a variation in different age groups. In addition, our study indicates that there is a significant
correlation between the number of pregnancies and the spine, trochanter, and Ward's triangle BMD, but there is no correlation
for the femur neck BMD.
Received: April 30, 2002 / Accepted: January 16, 2003
RID="*"
ID="*" Offprint requests to: A. Gur 相似文献
959.
960.
Alma MH Mavi A Yildirim A Digrak M Hirata T 《Biological & pharmaceutical bulletin》2003,26(12):1725-1729
In the present study, essential oil from the leaves of Syrian oreganum [Origanum syriacum L. (Lauraceae)] grown in Turkish state forests of the Dortyol district, Turkey, was obtained by steam distillation. The chemical composition of oil was analysed by GC and GC-MS, and was found to contain 49.02% monoterpenes, 36.60% oxygenated monoterpenes and 12.59% sesquiterpenes. The major components are as follows: gamma-terpinene, carvacrol, p-cymene and beta-caryophyllene. Subsequently, the reducing power, antioxidant and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activities of the essential oil were studied. The reducing power was compared with ascorbic acid, and the other activities were compared with 2,6-di-tert-butyl-4-methyl phenol (BHT, butylated hydroxytoluene). The results showed that the activities were concentration dependent. The antioxidant activities of the oil were slightly lower than those of ascorbic acid or BHT, so the oil can be considered an effective natural antioxidant. Antimicrobial activities of the essential oil from the leaves of Origanum syriacum was also determined on 16 microorganisms tested using the agar-disc diffusion method, and showed antimicrobial activity against 13 of these. 相似文献