全文获取类型
收费全文 | 855篇 |
免费 | 51篇 |
国内免费 | 60篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 47篇 |
妇产科学 | 19篇 |
基础医学 | 116篇 |
口腔科学 | 27篇 |
临床医学 | 103篇 |
内科学 | 168篇 |
皮肤病学 | 19篇 |
神经病学 | 21篇 |
特种医学 | 88篇 |
外科学 | 43篇 |
综合类 | 22篇 |
预防医学 | 60篇 |
眼科学 | 7篇 |
药学 | 169篇 |
中国医学 | 12篇 |
肿瘤学 | 44篇 |
出版年
2023年 | 2篇 |
2022年 | 2篇 |
2021年 | 6篇 |
2020年 | 2篇 |
2019年 | 13篇 |
2018年 | 16篇 |
2017年 | 5篇 |
2016年 | 18篇 |
2015年 | 14篇 |
2014年 | 27篇 |
2013年 | 35篇 |
2012年 | 21篇 |
2011年 | 25篇 |
2010年 | 31篇 |
2009年 | 33篇 |
2008年 | 35篇 |
2007年 | 70篇 |
2006年 | 43篇 |
2005年 | 33篇 |
2004年 | 30篇 |
2003年 | 23篇 |
2002年 | 21篇 |
2001年 | 13篇 |
2000年 | 12篇 |
1999年 | 15篇 |
1998年 | 37篇 |
1997年 | 37篇 |
1996年 | 27篇 |
1995年 | 27篇 |
1994年 | 29篇 |
1993年 | 21篇 |
1992年 | 7篇 |
1991年 | 23篇 |
1990年 | 7篇 |
1989年 | 26篇 |
1988年 | 23篇 |
1987年 | 14篇 |
1986年 | 12篇 |
1985年 | 11篇 |
1984年 | 11篇 |
1983年 | 14篇 |
1982年 | 13篇 |
1981年 | 20篇 |
1980年 | 15篇 |
1979年 | 6篇 |
1978年 | 10篇 |
1977年 | 10篇 |
1976年 | 11篇 |
1975年 | 4篇 |
1973年 | 2篇 |
排序方式: 共有966条查询结果,搜索用时 187 毫秒
961.
Mehta SH Gupta A Sahay S Godbole SV Joshi SN Reynolds SJ Celentano DD Risbud A Mehendale SM Bollinger RC 《Journal of acquired immune deficiency syndromes (1999)》2006,41(1):75-80
OBJECTIVE: To investigate changes over a decade in prevalence and correlates of HIV among high-risk women attending sexually transmitted infection (STI) clinics in Pune, India, who deny a history of commercial sex work (CSW). DESIGN: Cross-sectional. METHODS: From 1993 to 2002, 2376 women attending 3 STI clinics in Pune were offered HIV screening. Women who denied CSW were included (n = 1020). RESULTS: Of 1020 women, 21% were HIV infected. The annual HIV prevalence increased from 14% in 1993 to 29% in 2001-2002 (P < 0.001). The change in HIV prevalence over time was paralleled by changes in clinic visitor characteristics; in later periods, women were older, more often employed, less likely to be currently married, and more likely to report condom use. In multivariate analysis, factors independently associated with HIV were calendar period (adjusted odds ratio [AOR], 1.9 for 1997-1999 vs. 1993-1996; 95% CI, 1.2-3.0; AOR, 2.3 for 2000-2002 vs. 1993-1996; 95% CI, 1.5-3.6), lack of formal education (AOR, 2.0; 95% CI, 1.4-2.9), having been widowed (AOR, 3.1; 95% CI, 1.6-6.1), current employment (AOR, 1.8; 95% CI, 1.2-2.6), and genital ulcer disease on examination (AOR, 1.8; 95% CI, 1.2-2.7). CONCLUSIONS: Women attending STI clinics in India who deny a history of CSW represent a small, hidden subgroup, likely put at risk for HIV because of high-risk behavior of their male partners, generally their husbands. Educational and awareness efforts that have targeted other subgroups in India (men and CSWs) should also focus on these hard-to-reach women. Risk reduction in this subgroup of Indian women would also be expected to reduce perinatal infections in India. 相似文献
962.
Asian ginseng enhances the anti-proliferative effect of 5-fluorouracil on human colorectal cancer: Comparison between white and red ginseng 总被引:1,自引:0,他引:1
Anna B. Fishbein Chong-Zhi Wang Xiao-Li Li Sangeeta R. Mehendale Shi Sun Han H. Aung Chun-Su Yuan 《Archives of pharmacal research》2009,32(4):505-513
Previous studies showed that Asian ginseng, Panax ginseng C.A. Meyer, may have anti-cancer properties. However, there is limited data exploring the use of Asian ginseng as an adjuvant
to chemotherapy, and minimal mechanistic studies related to their possible synergistic activities. In this study, the content
of 8 ginsenosides, Rb1, Rb2, Rb3, Rc, Rd, Re, Rg1 and Rg3, in the extracts of white ginseng (WG) and red ginseng (RG) were
determined by HPLC. Using HCT-116 human colorectal cancer cells, we compared the efficacy of WG and RG. We evaluated the synergy
between ginseng and 5-fluorouracil (5-FU), and explored the mechanism of their anti-proliferative effects. As single extract,
WG or RG used at concentrations of 0.1, 0.2 and 0.3 mg/mL, inhibited HCT-116 cell proliferation in a concentration-related
manner. WG at 0.2 mg/mL did not show obvious synergy with 5-FU co-treatment, while RG at 0.2 and 0.3 mg/mL significantly enhanced
the anti-proliferative effects of 5-FU at concentrations of 10, 50 and 100 μM (P < 0.05). Using flow cytometric assay, RG 0.3 mg/mL did not affect cancer cell apoptotic induction activity. However, the
RG induced cell cycle arrest in the G1 phase, while 5-FU arrested the cell in the S phase. Different ginsenoside profiles
are responsible for the observed differences in pharmacological effects. The effects of 8 ginsenosides on HCT-116 cells were
assayed. Rd and Rg3 showed positive anti-proliferative effect. Our data suggested a potential for RG as an adjuvant therapy
in the treatment of colorectal cancer, via a synergistic action. 相似文献
963.
Solberg BC Dirksen CD Nieman FH van Merode G Poeze M Ramsay G 《Critical care (London, England)》2008,12(3):R68
Introduction
The high cost of critical care resources has resulted in strategies to reduce the costs of ruling out low-risk patients by developing intermediate care units (IMCs). The aim of this study was to compare changes in total hospital costs for intensive care patients before and after the introduction of an IMC at the University Hospital Maastricht. 相似文献964.
Hanekamp MN Mazer P van der Cammen-van Zijp MH van Kessel-Feddema BJ Nijhuis-van der Sanden MW Knuijt S Zegers-Verstraeten JL Gischler SJ Tibboel D Kollée LA 《Critical care (London, England)》2006,10(5):R127-11
Introduction
Extracorporeal membrane oxygenation (ECMO) is a supportive cardiopulmonary bypass technique for babies with acute reversible cardiorespiratory failure. We assessed morbidity in ECMO survivors at the age of five years, when they start primary school and major decisions for their school careers must be made. 相似文献965.
Limaye PB Bhave VS Palkar PS Apte UM Sawant SP Yu S Latendresse JR Reddy JK Mehendale HM 《Hepatology (Baltimore, Md.)》2006,44(2):379-388
Acute liver failure induced by hepatotoxic drugs results from rapid progression of injury. Substantial research has shown that timely liver regeneration can prevent progression of injury leading to a favorable prognosis. However, the mechanism by which compensatory regeneration prevents progression of injury is not known. We have recently reported that calpain released from necrotic hepatocytes mediates progression of liver injury even after the hepatotoxic drug is cleared from the body. By examining expression of calpastatin (CAST), an endogenous inhibitor of calpain in three liver cell division models known to be resistant to hepatotoxicity, we tested the hypothesis that increased CAST in the dividing hepatocytes affords resistance against progression of injury. Liver regeneration that follows CCl(4)-induced liver injury, 70% partial hepatectomy, and postnatal liver development were used. In all three models, CAST was upregulated in the dividing/newly divided hepatocytes and declined to normal levels with the cessation of cell proliferation. To test whether CAST overexpression confers resistance against hepatotoxicity, CAST was overexpressed in the livers of normal SW mice using adenovirus before challenging them with acetaminophen (APAP) overdose. These mice exhibited markedly attenuated progression of liver injury and 57% survival. Whereas APAP-bioactivating enzymes and covalent binding of the APAP-derived reactive metabolites remained unaffected, degradation of calpain specific target substrates such as fodrin was significantly reduced in these mice. In conclusion, CAST overexpression could be used as a therapeutic strategy to prevent progression of liver injury where liver regeneration is severely hampered. 相似文献
966.
目的通过观察香烟提取物对牛冠状动脉内皮细胞(BCAEC)的损伤作用,为研究吸烟与心血管疾病之间的关系提供依据。方法以吸烟者体内通常的尼古丁浓度为基准,分别用尼古丁、香烟主流烟雾提取物(MSW)和侧流烟雾提取物(SSW)对 BCAEC 进行染毒(尼古丁染毒终浓度分别为1×10~(-5)、0.8×10~(-5)、0.9×10~(-5)mol/L),用显微数码成像系统记录细胞形态变化,检测凋亡细胞与坏死细胞的发生比例,测定 caspase 酶活力。结果经尼古丁、MSW 处理的 BCAEC 形态上发生凋亡样变化,处理24 h 后凋亡细胞发生率为5.89%和11.94%。而 SSW 处理后的 BCAEC 呈坏死样变化.处理24 h 后62.84%的细胞发生坏死。尼古丁和 MSW 可诱导 caspase-3活力增高。结论香烟提取物可诱导牛冠状动脉内皮细胞损伤,MSW 可引起细胞凋亡,SSW 导致细胞坏死,caspase-3的激活可能是香烟提取物诱导牛冠状动脉内皮细胞凋亡的机制。 相似文献