The relationship of diet and exercise for weight control and the quality of life gap associated with diabetes

OBJECTIVE: The demanding behavioral changes for weight control to manage diabetes might contribute to lower quality of life (QOL). This research examines whether the demands of diet and exercise contribute to lower QOL among persons with diabetes. METHODS: Data were from the Behavioral Risk Factor Surveillance System (BRFSS), which measures days in the last month for poor physical health, poor mental health, limited activity, pain, depression, stress, poor sleep, and high energy, as well as weight control efforts. RESULTS: Respondents with diabetes averaged more impaired days on every measure of QOL. Neither efforts to control weight nor dieting were related to any measure. Exercise was associated with reductions in impaired days on all measures. CONCLUSIONS: Exercising to control weight had a powerful effect on reducing QOL differences while attempting to maintain or reduce weight, and dieting to do so had no effect.     

Gulf War veterans' illnesses: a pilot study of the relationship of illness beliefs to symptom severity and functional health status

This investigation describes the illness beliefs of veterans regarding their Gulf War-related health concerns and investigates the relationship of these illness beliefs to physical and mental health functioning. Gulf War veterans (N = 583) presenting for evaluation at a Veteran's Affairs and Department of Defense facility completed self-report measures of symptom-related beliefs, psychosocial distress, and functional status. Hierarchical multiple regression analyses were performed to determine the extent that symptom-related beliefs impacted symptom-reporting and functional status independent of demographic factors and psychiatric illness. Several beliefs predicted physical symptom reporting and functional impairment in physical health and mental health domains after controlling for demographic variables and psychiatric illness. Gulf War veterans' illness beliefs may impact clinical outcomes. Discussing illness beliefs and providing accurate information is an important component of medical care for Gulf War veterans.     

Potent N-(1,3-thiazol-2-yl)pyridin-2-amine vascular endothelial growth factor receptor tyrosine kinase inhibitors with excellent pharmacokinetics and low affinity for the hERG ion channel

A series of N-(1,3-thiazol-2-yl)pyridin-2-amine KDR kinase inhibitors have been developed that possess optimal properties. Compounds have been discovered that exhibit excellent in vivo potency. The particular challenges of overcoming hERG binding activity and QTc increases in vivo in addition to achieving good pharmacokinetics have been acomplished by discovering a unique class of amine substituents. These compounds have a favorable kinase selectivity profile that can be accentuated with appropriate substitution.     

Comparison of pulmonary function and postoperative pain after laparoscopic versus open gastric bypass: a randomized trial

BACKGROUND: Impairment of pulmonary function is common after upper abdominal operations. The purpose of this study was to compare postoperative pulmonary function and analgesic requirements in patients undergoing either laparoscopic or open Roux-en-Y gastric bypass (GBP). STUDY DESIGN: Seventy patients with a body mass index of 40 to 60 kg/m2 were randomly assigned to undergo laparoscopic (n = 36) or open (n = 34) GBP. The two groups were similar in age, gender, body mass index, pulmonary history, and baseline pulmonary function. Pulmonary function studies were performed preoperatively and on postoperative days 1, 2, 3, and 7. Oxygen saturation and chest radiographs were performed on both groups preoperatively and on postoperative day 1. Postoperative pain was evaluated using a visual analog scale and the amount of narcotic consumed was recorded. Data are presented as mean +/- standard deviation. RESULTS: Laparoscopic GBP patients had significantly less impairment of pulmonary function than open GBP patients on the first three postoperative days (p < 0.05). By the 7th postoperative day, all pulmonary function parameters in the laparoscopic GBP group had returned to within preoperative levels, but only one parameter (peak expiratory flow) had returned to preoperative levels in the open GBP group. On the first postoperative day, laparoscopic GBP patients used less morphine than open GBP patients (46 +/- 31 mg versus 76 +/- 39 mg, respectively, p < 0.001), and visual analog scale pain scores at rest and during mobilization were lower after laparoscopic GBP than after open GBP (p < 0.05). Fewer patients after laparoscopic GBP than after open GBP developed hypoxemia (31% versus 76%, p < 0.001) and segmental atelectasis (6% versus 55%, p = 0.003). CONCLUSION: Laparoscopic gastric bypass resulted in less postoperative suppression of pulmonary function, decreased pain, improved oxygenation, and less atelectasis than open gastric bypass.     

Outcomes of a small group educational intervention for urinary incontinence: episodes of incontinence and other urinary symptoms

OBJECTIVES. This community-based intervention to reduce urinary incontinence (UI) in elderly women used a small group educational approach. This article reports on change in episodes of incontinence and other urinary symptoms. METHODS. Participants were randomly assigned to intervention or wait control condition. This article is restricted to 49 intervention and 59 control participants with acceptable diaries. RESULTS. There was a significant treatment effect for a number of incontinent episodes. In the intervention group, 61% had a 50% or greater reduction in episodes, with more than one third having 100% reduction; 38% of the control group had a reduction of 50% or greater. One year postprogram, 75% of treated women reported subjective improvement. There was a reduction in frequency of daily, but not nocturnal, micturition. DISCUSSION. This community-based intervention is an encouraging option for behavioral treatment of UI. Public health models may be particularly appropriate with moderate levels of urinary incontinence.     

Outcomes of a small group educational intervention for urinary incontinence: health-related quality of life

OBJECTIVES. This article examines change in general and condition-specific measures of health-related quality of life (HRQL) among participants in a randomized trial of a community-based intervention for urinary incontinence (UI). METHODS. Participants were randomized into intervention or wait control conditions. Participants were women aged 65 or older with urinary incontinence residing in Oklahoma. General HRQL measures included the Physical Function, Mental Health, Vitality, and Health Perceptions subscales of the Medical Outcomes Study Short Form-36. Condition-specific measures included the Impact of UI and self-management strategies. RESULTS. There were no significant group effects for the general HRQL measures. Intervention participants reported decreased Impact of UI and greater change in self-management strategies than control participants. DISCUSSION. The intervention affected condition-specific quality of life and self-management but not general HRQL. The intervention's impact on quality of life involves change in how the condition is seen as impacting on life and on selection of self-management behaviors.     

Endocrine and metabolic response in the human newborn to first feed of breast milk

The hormonal and metabolic response to the first feed of breast milk was studied in 12 infants at 4-6 hours of age. After the feed there was an increase in blood glucose concentration but no changes in the concentrations of lactate, pyruvate, alanine, or ketone bodies. The feed was followed by an increase in the concentrations of plasma insulin, growth hormone, gastrin, and enteroglucagon, but no change in levels of plasma glucagon or gastric inhibitory peptide. Several hormone systems are functionally active at birth and are stimulated by the first feed of milk.     

Tackling health literacy: adaptation of public hypertension educational materials for an Indo-Asian population in Canada

Background  

Indo-Asians in Canada are at increased risk for cardiovascular diseases. There is a need for cultural and language specific educational materials relating to this risk. During this project we developed and field tested the acceptability of a hypertension public education pamphlet tailored to fit the needs of an at risk local Indo-Asian population, in Calgary, Alberta, Canada.