全文获取类型
收费全文 | 1649篇 |
免费 | 107篇 |
国内免费 | 30篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 61篇 |
妇产科学 | 11篇 |
基础医学 | 168篇 |
口腔科学 | 128篇 |
临床医学 | 127篇 |
内科学 | 428篇 |
皮肤病学 | 24篇 |
神经病学 | 111篇 |
特种医学 | 236篇 |
外科学 | 172篇 |
综合类 | 34篇 |
一般理论 | 1篇 |
预防医学 | 164篇 |
眼科学 | 11篇 |
药学 | 43篇 |
中国医学 | 9篇 |
肿瘤学 | 42篇 |
出版年
2023年 | 14篇 |
2022年 | 24篇 |
2021年 | 35篇 |
2020年 | 26篇 |
2019年 | 30篇 |
2018年 | 40篇 |
2017年 | 31篇 |
2016年 | 33篇 |
2015年 | 38篇 |
2014年 | 50篇 |
2013年 | 56篇 |
2012年 | 73篇 |
2011年 | 85篇 |
2010年 | 62篇 |
2009年 | 71篇 |
2008年 | 68篇 |
2007年 | 93篇 |
2006年 | 66篇 |
2005年 | 69篇 |
2004年 | 47篇 |
2003年 | 71篇 |
2002年 | 42篇 |
2001年 | 32篇 |
2000年 | 27篇 |
1999年 | 39篇 |
1998年 | 53篇 |
1997年 | 50篇 |
1996年 | 40篇 |
1995年 | 23篇 |
1994年 | 43篇 |
1993年 | 26篇 |
1992年 | 15篇 |
1991年 | 17篇 |
1990年 | 12篇 |
1989年 | 30篇 |
1988年 | 22篇 |
1987年 | 21篇 |
1986年 | 32篇 |
1985年 | 16篇 |
1984年 | 20篇 |
1983年 | 13篇 |
1982年 | 15篇 |
1981年 | 27篇 |
1979年 | 6篇 |
1978年 | 11篇 |
1977年 | 11篇 |
1976年 | 12篇 |
1975年 | 12篇 |
1969年 | 8篇 |
1968年 | 7篇 |
排序方式: 共有1786条查询结果,搜索用时 31 毫秒
31.
Genetic Analysis of PARK2 and PINK1 Genes in Brazilian Patients with Early-Onset Parkinson's Disease
Karla Cristina Vasconcelos Moura Mário Campos Junior Ana Lúcia Zuma de Rosso Denise Hack Nicaretta Jo?o Santos Pereira Delson José Silva Flávia Lima dos Santos Fabíola da Costa Rodrigues Cíntia Barros Santos-Rebou?as Márcia Mattos Gon?alves Pimentel 《Disease markers》2013,35(3):181-185
Parkinson''s disease is the second most frequent neurodegenerative disorder in the world, affecting 1-2% of individuals over the age of 65. The etiology of Parkinson''s disease is complex, with the involvement of gene-environment interactions. Although it is considered a disease of late manifestation, early-onset forms of parkinsonism contribute to 5–10% of all cases. In the present study, we screened mutations in coding regions of PARK2 and PINK1 genes in 136 unrelated Brazilian patients with early-onset Parkinson''s disease through automatic sequencing. We identified six missense variants in PARK2 gene: one known pathogenic mutation, two variants of uncertain role, and three nonpathogenic changes. No pathogenic mutation was identified in PINK1 gene, only benign polymorphisms. All putative pathogenic variants found in this study were in heterozygous state. Our data show that PARK2 point mutations are more common in Brazilian early-onset Parkinson''s disease patients (2.9%) than PINK1 missense variants (0%), corroborating other studies worldwide. 相似文献
32.
MicroCT assessment of bone microarchitecture in implant sites reconstructed with autogenous and xenogenous grafts: a pilot study 下载免费PDF全文
33.
34.
Susane Müller Klug Passos Luciano Dias de Mattos Souza Bárbara Coiro Spessato 《AIDS care》2014,26(11):1379-1382
A cross-sectional study was developed to evaluate suicide risk and associated factors in HIV/AIDS patients at a regional reference center for the treatment of HIV/AIDS in southern Brazil. We assessed 211 patients in regard to suicide risk, clinical and sociodemographic characteristics, drug use, depression, and anxiety. Suicide risk was assessed with Mini International Neuropsychiatric Interview, Module C. Multivariate analysis was performed using Poisson regression. Of the total sample, 34.1% were at risk of suicide. In the multivariate analysis, the following variables were independently associated with suicide risk: female gender; age up to 47 years; unemployment; indicative of anxiety; indicative of depression; and abuse or addiction on psychoactive substances. Suicide risk is high in this population. Psychosocial factors should be included in the physical and clinical evaluation, given their strong association with suicide risk. 相似文献
35.
36.
Andresa Marques de Mattos Larissa Vieira Marino Paula Payão Ovidio Alceu Afonso Jordão Carla Cristina Almeida Paula Garcia Chiarello 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》2012,16(1):68-74
Our aim was to investigate and determine the associations between oxidative stress (OS), dyslipidemia and inflammation in patients treated with continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis (HD) using observational cross‐sectional study. Twenty patients in CAPD and 48 in HD for at least 8 weeks and aged ≥18 years were included in the study. Individuals with malignant or acute inflammatory disease were excluded. A control group of 17 healthy individuals was also recruited. The biochemical parameter evaluations were analyzed using colorimetric kits for albumin, serum glucose, total cholesterol (TC) and lipid fractions. To determine the inflammatory status, CRP, IL‐6 and TNF‐α were analyzed by automated chemiluminescence kits. Plasma advanced oxidation protein products (AOPP) were determined by spectrophotometry. Mean AOPP levels were significantly higher for the HD group compared to the control, and there was no difference in AOPP concentrations between the control and CAPD groups. Dialysis patients had levels of inflammatory parameters higher than controls, and showed a high prevalence of patients with dyslipidemia, especially in CAPD. In the HD group, AOPP was positively correlated with triglycerides (TG) and inversely associated with HDL. Also the HD group was observed to have negative associations between TNF‐α and HDL, LDL and TC. In the CAPD group, CRP was inversely correlated with HDL. Hemodialysis patients had increased protein OS and associations of inflammation and dyslipidemia were also observed in these dialysis groups. A more detailed characterization of the relations between oxidative stress and other more traditional risk factors has therapeutic importance, since cardiovascular diseases are the leading cause of death among dialysis patients. 相似文献
37.
C.O. Lisboa M.M. Martins A.C.O. Ruellas D.M.T.P. Ferreira L.C. Maia C.T. Mattos 《International journal of oral and maxillofacial surgery》2018,47(11):1389-1397
The aim of this systematic review was to evaluate the effects of mandibular advancement or setback surgery on the facial soft tissue assessed using three-dimensional images. An electronic search was performed in the MEDLINE, Cochrane Library, Scopus, Virtual Health Library (VHL), Web of Science, and OpenGrey databases. Inclusion criteria comprised studies that evaluated the soft tissues of adult patients before and after mandibular advancement or setback surgery using computed tomography or magnetic resonance imaging. The risk of bias was analyzed. A total of 3501 studies were retrieved. The titles and abstracts of 2071 studies were read and 2040 of them were excluded. Thirty-one articles were read in full and six fulfilled the eligibility criteria and were included. A meta-analysis was performed using three of these articles. The correlation was significant and strong in the chin area (r = 0.876 and r = 0.868) and moderate for the lower lip/lower incisor (r = 0.690). The ratio for lower lip/infradentale was 78% and for Pog′/Pog was 98%. Due to the limited number of articles included, there is weak evidence to infer that changes in the facial soft tissue due to mandibular advancement or setback are significant, but changes in the lower lip tend to be smaller than changes in the chin area. 相似文献
38.
39.
40.