全文获取类型
收费全文 | 7054篇 |
免费 | 443篇 |
国内免费 | 98篇 |
专业分类
耳鼻咽喉 | 88篇 |
儿科学 | 104篇 |
妇产科学 | 131篇 |
基础医学 | 750篇 |
口腔科学 | 267篇 |
临床医学 | 584篇 |
内科学 | 2227篇 |
皮肤病学 | 86篇 |
神经病学 | 615篇 |
特种医学 | 250篇 |
外科学 | 1178篇 |
综合类 | 14篇 |
一般理论 | 1篇 |
预防医学 | 292篇 |
眼科学 | 73篇 |
药学 | 335篇 |
中国医学 | 6篇 |
肿瘤学 | 594篇 |
出版年
2024年 | 14篇 |
2023年 | 136篇 |
2022年 | 263篇 |
2021年 | 472篇 |
2020年 | 277篇 |
2019年 | 314篇 |
2018年 | 347篇 |
2017年 | 246篇 |
2016年 | 289篇 |
2015年 | 298篇 |
2014年 | 389篇 |
2013年 | 434篇 |
2012年 | 617篇 |
2011年 | 545篇 |
2010年 | 305篇 |
2009年 | 296篇 |
2008年 | 399篇 |
2007年 | 361篇 |
2006年 | 334篇 |
2005年 | 264篇 |
2004年 | 211篇 |
2003年 | 175篇 |
2002年 | 136篇 |
2001年 | 46篇 |
2000年 | 35篇 |
1999年 | 30篇 |
1998年 | 28篇 |
1997年 | 16篇 |
1996年 | 20篇 |
1995年 | 18篇 |
1994年 | 14篇 |
1992年 | 11篇 |
1991年 | 12篇 |
1990年 | 14篇 |
1989年 | 21篇 |
1988年 | 22篇 |
1987年 | 20篇 |
1986年 | 16篇 |
1985年 | 16篇 |
1979年 | 8篇 |
1978年 | 10篇 |
1977年 | 16篇 |
1976年 | 8篇 |
1974年 | 16篇 |
1973年 | 6篇 |
1972年 | 7篇 |
1971年 | 8篇 |
1970年 | 8篇 |
1969年 | 7篇 |
1966年 | 5篇 |
排序方式: 共有7595条查询结果,搜索用时 11 毫秒
121.
Massimiliano Cadamuro Simone Brivio Joachim Mertens Marta Vismara Anja Moncsek Chiara Milani Christian Fingas Maria Cristina Malerba Giorgia Nardo Luigi DallOlmo Eleonora Milani Valeria Mariotti Tommaso Stecca Marco Massani Carlo Spirli Romina Fiorotto Stefano Indraccolo Mario Strazzabosco Luca Fabris 《Journal of hepatology》2019,70(4):700-709
122.
Libani IV Guy EC Melchiori L Schiro R Ramos P Breda L Scholzen T Chadburn A Liu Y Kernbach M Baron-Lühr B Porotto M de Sousa M Rachmilewitz EA Hood JD Cappellini MD Giardina PJ Grady RW Gerdes J Rivella S 《Blood》2008,112(3):875-885
In β-thalassemia, the mechanism driving ineffective erythropoiesis (IE) is insufficiently understood. We analyzed mice affected by β-thalassemia and observed, unexpectedly, a relatively small increase in apoptosis of their erythroid cells compared with healthy mice. Therefore, we sought to determine whether IE could also be characterized by limited erythroid cell differentiation. In thalassemic mice, we observed that a greater than normal percentage of erythroid cells was in S-phase, exhibiting an erythroblast-like morphology. Thalassemic cells were associated with expression of cell cycle–promoting genes such as EpoR, Jak2, Cyclin-A, Cdk2, and Ki-67 and the antiapoptotic protein Bcl-XL. The cells also differentiated less than normal erythroid ones in vitro. To investigate whether Jak2 could be responsible for the limited cell differentiation, we administered a Jak2 inhibitor, TG101209, to healthy and thalassemic mice. Exposure to TG101209 dramatically decreased the spleen size but also affected anemia. Although our data do not exclude a role for apoptosis in IE, we propose that expansion of the erythroid pool followed by limited cell differentiation exacerbates IE in thalassemia. In addition, these results suggest that use of Jak2 inhibitors has the potential to profoundly change the management of this disorder. 相似文献
123.
Prof. Leonardo Marzio MD Matteo Neri MD Anna Maria Di Giammarco MD Franco Cuccurullo MD Giorgio Assuero Lanfranchi MD 《Digestive diseases and sciences》1986,31(4):349-354
The effect of dopamine on human gastric and small intestinal interdigestive motility was investigated in 12 subjects. Intestinal motility was recorded by means of a four-lumen polyvinyl probe with four open tips located 15 cm apart, continuously perfused with distilled water. In each subject during the same study, after recording two consecutive spontaneous phase III of migrating myoelectrical complexes and when a phase II appeared, dopamine was infused intravenously twice in a dose of 5 g/kg/min for 15 min with an interval of 20 min between each infusion. In six subjects, the second dopamine infusion was preceded by a treatment with sulpiride (10 mg, intravenously, as bolus) or domperidone (10 mg, intravenously, as bolus), each considered a highly selective dopamine antagonist. The results show that dopamine stimulates duodenal motility producing a pattern similar to that observed in phase III of spontaneously occurring migrating myoelectrical complexes. The second dopamine infusion reproduced in all cases the same pattern of motility as observed during the first infusion. Sulpiride and domperidone prevented the effect of dopamine in all cases. It is therefore suggested that dopamine-induced duodenal motility may involve specific dopaminergic receptors. 相似文献
124.
125.
Bertini M Ziacchi M Biffi M Martignani C Saporito D Valzania C Diemberger I Cervi E Frisoni J Sangiorgi D Branzi A Boriani G 《The American journal of cardiology》2008,102(10):1373-1377
Present devices for cardiac resynchronization therapy offer the possibility of tailoring the hemodynamic effect of biventricular pacing by optimization of the interventricular delay (VV) beyond atrioventricular (AV)-interval optimization. It was not yet defined whether a QRS width-based strategy may be a helpful tool for echocardiography for device programming. The aim of the study was to investigate the relation between VV-interval optimization guided by echocardiography and guided by QRS interval width. One hundred six patients with a cardiac resynchronization therapy device for > or =3 months were enrolled. All patients underwent echocardiographic AV and VV delay optimization. The AV interval was optimized according to the E wave-A wave (EA) interval and left ventricular filling time. At the optimal AV delay, VV optimization was performed by measuring the aortic velocity time integral at 5 different settings: simultaneous right and left ventricle output, left ventricle pre-excitation (left ventricle + 40 and 80 ms, respectively), and right ventricle pre-excitation (right ventricle + 40 and 80 ms, respectively). A 12-lead electrocardiogram was recorded and QRS duration was measured in the lead with the greatest QRS width. The electrocardiographic (ECG)-optimized VV interval was defined according to the narrowest achievable QRS interval among 5 VV intervals. The echocardiographic-optimized VV interval was left ventricle + 40 ms in 28 patients, left ventricle + 80 ms in 15 patients, simultaneous in 46 patients, right ventricle + 40 ms in 14 patients, and right ventricle + 80 ms in 3 patients. Significant concordance (kappa = 0.69, p <0.001) was found between the echocardiographic- and ECG-optimized VV interval. In conclusion, significant concordance appeared to exist during biventricular pacing between VV programming based on the shortest QRS interval at 12-lead ECG pacing and echocardiographic-guided VV-interval optimization. A combined ECG- and echocardiographic approach could be a less time-consuming solution in performing this operation. 相似文献
126.
Paolo Ortolani Antonio Marzocchi Cinzia Marrozzini Tullio Palmerini Francesco Saia Carlo Serantoni Matteo Aquilina Simona Silenzi Federica Baldazzi Daniele Grosseto Nevio Taglieri Robin M T Cooke Maria Letizia Bacchi-Reggiani Angelo Branzi 《European heart journal》2006,27(13):1550-1557
AIMS: Treatment delay is a powerful predictor of survival in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI). We investigated effectiveness of pre-hospital diagnosis of STEMI with direct referral to PCI, alongside more conventional referral strategies. METHODS AND RESULTS: From January 2003 to December 2004, 658 STEMI patients were referred for primary PCI at our intervention laboratory. Three predefined referral routes were compared: (1) for patients within 90 min drive of the PCI centre, pre-hospital diagnosis and direct transportation (n=166), (2) diagnosis at the interventional hospital emergency department (n=316), (3) diagnosis at local hospitals before transportation (n = 176). Pre-hospital diagnosis was associated with more than 45 min reduction in treatment delay (P = 0.001). No significant difference in in-hospital mortality was apparent in the overall study population. In the cardiogenic shock subgroup (n = 80), pre-hospital diagnosis was associated with a two-thirds reduction in in-hospital mortality (P = 0.019); mortality was only 6.2% in shock patients who underwent PCI in < 2 h. CONCLUSION: This study shows that pre-hospital diagnosis can provide a reduction in primary PCI treatment delay, and suggests the hypothesis that this referral strategy might provide survival benefits to patients with cardiogenic shock. 相似文献
127.
Giulia Rivasi MD Matteo Bulgaresi MD Chiara Bandinelli MD Daniela Balzi BSc Francesca Tarantini PhD Silvia Tognelli MD Chiara Lorini PhD Primo Buscemi MD Lorenzo Baggiani MD Giancarlo Landini MD Andrea Ungar PhD Guglielmo Bonaccorsi MD Enrico Mossello PhD Enrico Benvenuti MD 《Journal of the American Geriatrics Society》2022,70(5):1336-1341
128.
129.
Gagliardi Federica Lauro Augusto Tripodi Domenico Amabile Maria Ida Palumbo Piergaspare Di Matteo Filippo Maria Palazzini Giorgio Forte Flavio Frattaroli Stefano Khouzam Simone Marino Ignazio R. DAndrea Vito Sorrenti Salvatore Pironi Daniele 《Digestive diseases and sciences》2022,67(3):786-798
Digestive Diseases and Sciences - Mesenteric cysts are defined as a heterogeneous group of intra-abdominal cystic lesions of the mesentery or omentum that may be found in any portion of the... 相似文献
130.
Irene Paganini Vivian Y Chang Gabriele L Capone Jeremie Vitte Matteo Benelli Lorenzo Barbetti Roberta Sestini Eva Trevisson Theo JM Hulsebos Marco Giovannini Stanley F Nelson Laura Papi 《European journal of human genetics : EJHG》2015,23(7):963-968
Schwannomatosis is characterized by the development of multiple non-vestibular, non-intradermal schwannomas. Constitutional inactivating variants in two genes, SMARCB1 and, very recently, LZTR1, have been reported. We performed exome sequencing of 13 schwannomatosis patients from 11 families without SMARCB1 deleterious variants. We identified four individuals with heterozygous loss-of-function variants in LZTR1. Sequencing of the germline of 60 additional patients identified 18 additional heterozygous variants in LZTR1. We identified LZTR1 variants in 43% and 30% of familial (three of the seven families) and sporadic patients, respectively. In addition, we tested LZTR1 protein immunostaining in 22 tumors from nine unrelated patients with and without LZTR1 deleterious variants. Tumors from individuals with LZTR1 variants lost the protein expression in at least a subset of tumor cells, consistent with a tumor suppressor mechanism. In conclusion, our study demonstrates that molecular analysis of LZTR1 may contribute to the molecular characterization of schwannomatosis patients, in addition to NF2 mutational analysis and the detection of chromosome 22 losses in tumor tissue. It will be especially useful in differentiating schwannomatosis from mosaic Neurofibromatosis type 2 (NF2). However, the role of LZTR1 in the pathogenesis of schwannomatosis needs further elucidation. 相似文献