全文获取类型
收费全文 | 7936篇 |
免费 | 461篇 |
国内免费 | 99篇 |
专业分类
耳鼻咽喉 | 94篇 |
儿科学 | 136篇 |
妇产科学 | 146篇 |
基础医学 | 842篇 |
口腔科学 | 292篇 |
临床医学 | 634篇 |
内科学 | 2518篇 |
皮肤病学 | 88篇 |
神经病学 | 672篇 |
特种医学 | 275篇 |
外科学 | 1238篇 |
综合类 | 18篇 |
一般理论 | 3篇 |
预防医学 | 367篇 |
眼科学 | 73篇 |
药学 | 400篇 |
中国医学 | 6篇 |
肿瘤学 | 694篇 |
出版年
2024年 | 15篇 |
2023年 | 138篇 |
2022年 | 264篇 |
2021年 | 487篇 |
2020年 | 286篇 |
2019年 | 319篇 |
2018年 | 354篇 |
2017年 | 251篇 |
2016年 | 304篇 |
2015年 | 314篇 |
2014年 | 413篇 |
2013年 | 455篇 |
2012年 | 667篇 |
2011年 | 577篇 |
2010年 | 314篇 |
2009年 | 311篇 |
2008年 | 438篇 |
2007年 | 398篇 |
2006年 | 377篇 |
2005年 | 309篇 |
2004年 | 244篇 |
2003年 | 213篇 |
2002年 | 163篇 |
2001年 | 79篇 |
2000年 | 64篇 |
1999年 | 72篇 |
1998年 | 42篇 |
1997年 | 21篇 |
1996年 | 27篇 |
1995年 | 27篇 |
1994年 | 26篇 |
1993年 | 15篇 |
1992年 | 49篇 |
1991年 | 36篇 |
1990年 | 34篇 |
1989年 | 47篇 |
1988年 | 33篇 |
1987年 | 41篇 |
1986年 | 32篇 |
1985年 | 34篇 |
1984年 | 18篇 |
1983年 | 19篇 |
1979年 | 24篇 |
1978年 | 16篇 |
1977年 | 10篇 |
1974年 | 22篇 |
1972年 | 10篇 |
1971年 | 11篇 |
1970年 | 11篇 |
1966年 | 9篇 |
排序方式: 共有8496条查询结果,搜索用时 15 毫秒
991.
992.
Matteo Brucoli Paolo Boffano Irene Romeo Chiara Corio Arnaldo Benech Muhammad Ruslin Tymour Forouzanfar Thomas Starch‐Jensen Tanía Rodríguez‐Santamarta Juan Carlos de Vicente Johanna Snll Hanna Thorn Marko Tarle Emil Dediol Petia Pechalova Nikolai Pavlov Hristo Daskalov Iva Doykova Kadri Kelemith Tiia Tamme Andrey Kopchak Ievgen Shumynskyi Pierre Corre Helios Bertin Quentin Goguet Marine Anquetil Aurlien Louvrier Christophe Meyer Tadej Dovak David Vozli
Ane Birk Boban Ani
i Vitomir S. Konstantinovic 《Dental traumatology》2020,36(3):241-246
993.
Landi F Onder G Carpenter I Cesari M Soldato M Bernabei R 《Journal of clinical epidemiology》2007,60(5):518-524
ObjectivesThe aims of the study were to describe the prevalence of physical activity in a sample of older adults in home care in Europe and to examine the relationship between physical activity and incident disability.Study Design and SettingStudy population consisted of a random sample of 2,005 subjects aged 65 or older admitted to home care programs in 11 European Home Health Agencies who participated in AgeD in HOme Care project. Participants who reported spending 2 or more hours of physical activities in last 3 days were defined physically active. Disability performing activities of daily living was defined as the need of assistance in one or more of the following ADL: eating, dressing, transferring, mobility in bed, personal hygiene, and toileting.ResultsMore than 50% of participants were physically active. During a median follow-up of 12 months, 370 subjects (15%) became disabled. After adjusting for age, gender, and other possible confounding variables, active subjects were significantly less likely to become disabled compared to those reporting no or very low-intensity physical activity (OR, 0.67; 95% CI 0.53–0.84).ConclusionsThese findings support the possibility that physical activity has an independent effect on functional autonomy among frail and old people. 相似文献
994.
Venous outflow reconstructions with the piggyback technique in liver transplantation: a single-center experience of 431 cases 总被引:1,自引:0,他引:1
Matteo Cescon Gian Luca Grazi Giovanni Varotti Matteo Ravaioli Giorgio Ercolani rea Gardini Antonino Cavallari 《Transplant international》2005,18(3):318-325
The ideal method of venous outflow reconstruction with the piggyback technique (PB) in orthotopic liver transplantation (OLT) is not well-established. The complications related to PB in 431 primary OLTs were analyzed comparing the orifices used for the anastomosis (cuff of the recipient left and middle hepatic veins [LM], LM with a >1 cm cavoplasty [LM+], or also including the right hepatic vein [LMR]). Treatment strategies and outcome were also evaluated. Twenty patients (4.6%) experienced complications: 13 of 120 (10.8%) with LM, four of 225 (1.8%) with LM+, and three of 86 (3.5%) with LMR (LM versus LM+: P < 0.0001; LM versus LMR: P = NS; LM+ versus LMR = NS). Balloon dilation was successful in 10 of 13 cases in which it was attempted (77%). Eight patients required retransplantation (40%). Three patients (0.7%) died from causes linked to stenosis. Five-year survival of patients with and without complications was 75% and 79%, respectively (P =NS); 5-year graft survival was 50% and 76%, respectively (P = 0.001). The stump formed by the recipient left and middle hepatic veins with a transversal incision >1 cm of the caval wall constantly provides an adequate width for the caval anastomosis with the PB. 相似文献
995.
Alessandro Serretti Chiara Fabbri Silvia Pellegrini Stefano Porcelli Pierluigi Politi Silvio Bellino Marco Menchetti Veronica Mariotti Cristina Demi Valentina Martinelli Marco Cappucciati Paola Bozzatello Elena Brignolo Paolo Brambilla Chi-Un Pae Matteo Balestrieri Diana De Ronchi 《Psychiatry investigation》2013,10(2):180-189
Objective
Gene variants within the serotonin pathway have been associated with major depressive disorder (MDD) treatment outcomes, however a possible different modulation on pharmacological or psychological treatments has never been investigated.Methods
One hundred sixty MDD patients were partially randomized to either inter-personal counseling (IPC) or antidepressants. The primary outcome was remission at week 8. Five serotonergic polymorphisms were investigated (COMT rs4680, HTR1A rs6295, HTR2A rs2224721, HTR2A rs7997012 and SLC6A4 rs421417).Results
IPC (n=43) and antidepressant (n=117) treated patients did not show any difference in remission rates at week 8 (corrected for baseline severity, age and center). None of the studied gene variants impacted on response and remission rates at week 8 neither in the IPC nor in the antidepressant group. An analysis of the whole sample showed a trend of association between rs7997012 AA genotype and a better treatment outcome.Conclusion
Our study confirms that IPC is an effective psychological intervention comparable to antidepressants in mild-moderate MDD. Polymorphisms related to the serotonin system did not exert a major effect on clinical outcomes in none of the treatment groups. 相似文献996.
Giuseppe Citerio Jan Bakker Matteo Bassetti Dominique Benoit Maurizio Cecconi J. Randall Curtis Gordon S. Doig Margaret Herridge Samir Jaber Michael Joannidis Laurent Papazian Anders Perner Mark J. Peters Pierre Singer Martin Smith Marcio Soares Antoni Torres Antoine Vieillard-Baron Jean-François Timsit Elie Azoulay 《Intensive care medicine》2015,41(2):179-191
997.
Ivana Magnani Nicoletta Sacchi Marlene Darfler Paul E. Nisson Raffaella Tornaghi Anna Maria Fuhrman-Contl 《Clinical genetics》1993,43(4):180-185
A constitutional chromosome 14 rearrangement was observed in a female with a psychodevelopmental disorder. Karyotype analysis using a variety of chromosome techniques, QFQ, GTG, CBG, Ag-NOR and DA-DAPI, showed a deletion of chromosome 14q32.1-qter region in association with a supernumerary marker chromosome. The marker, resembling a submetacentric, approximately half the size of a G group chromosome is C band and Ag-NOR negative. The heteromorphism of the satellites showed that the deleted chromosome 14 is paternal in origin. Chromosome painting using an Alu-PCR probe specific for the human chromosome 14 and fluorescent in situ hybridization (FISH) showed that the marker contains chromosome 14q32 sequences. It is likely that the marker was generated from the deleted chromosome 14 region through a complex rearrangement. 相似文献
998.
Introduction – An increase of Parkinson's disease (PD) mortality has been observed in various countries during the last 3 decades. An analysis was done in order to define whether this trend could be due to a cohort effect. Material & methods – The mortality from PD in Italy during the period 1963–1987 was analyzed by means of a simplified cohort method. A mortality rate ratio (MRR) was also calculated, reporting all rates to 1906–1910 birth-cohort. Results – The mean annual mortality rates from PD sharply increased during the period of the study. The MRRs increased from the cohort born between 1881 and 1885, to a maximum in the cohort born between 1906 and 1910, and then markedly decreased in the following cohorts. Conclusion – According to our findings, the increase of PD mortality could be partly ascribed to an higher risk of dying from PD experienced by the cohorts of people born in the first decade of this century. 相似文献
999.
1000.
5-Methyl-2,2,2-trifluoroethylsulfonyl-1H-benzimidazole (BI-L-45 XX) inhibits both neutrophil enzyme release and chemotaxis in vitro and also inhibits chemotaxis in vivo. BI-L-45 XX has an IC50 between 16 microM and 25 microM in inhibiting lysosomal enzyme release from human peripheral blood neutrophils. In a Boyden chamber experiment, BI-L-45 XX inhibited migration in response to fMLP with an IC50 of 5 microM. When given orally to passively sensitized rats at doses of 0.1 to 1.0 mg/kg, it inhibited migration of neutrophils to the pleural cavity in response to an antigen (ovalbumin) challenge. BI-L-45 XX also shows activity in the developing adjuvant arthritis model, with an ED50 of 45 mg/kg, while exhibiting no significant inhibition of cyclooxygenase in a human platelet assay. This suggests the possibility that its antiinflammatory activity may be in part mediated by its effect on neutrophil function. 相似文献