Eye movements of teenage children of schizophrenics: A possible inherited marker of susceptibility to the disease

Teenage children each having one schizophrenic parent showed deficits in oculomotor control which are also found in schizophrenic subjects compared with controls. They made significantly more saccadic eye movements interrupting smooth pursuit ocular tracking. They also made significantly more double-jump saccadic movements in a looking task. Since this latter difference was true only when the visual target was illuminated during the saccade (p<0.001), the cause was likely visual processing and not a fixation stability problem. The two measures correlated significantly for all subjects (r = 0.63), and half the experimentals had scores more than two standard deviations above the mean for controls. This suggests that a pattern of oculomotor dysfunction found in schizophrenics which comes from a single source may act as a maker for susceptibility of their offspring to the disease.     

Laboratory standardizatin in an international study: the Kaunas--Rotterdam intervention study (KRIS).

Laboratory results obtained in different laboratories over lengthy periods of time usually are difficult to compare. In cooperative long-term studies where such results must be pooled, thorough standardization of methods is vital. We describe a program in which comparable plasma cholesterol and glucose analyses have been obtained, by simple methods. In the Netherlands and the Soviet Union in close collaboration with the Center for Disease Control, Atlanta, Ga., U.S.A. The two laboratories produced glucose values (direct o-toluidine reaction) within 2% of the target reference values and cholesterol results (direct Liebermann-Burchard reaction) with a consistent 6-8% positive bias over the reference method values. Intralaboratory precision was subject to preset acceptance limits. The use of common control materials, exchange of patient samples, and on-site comparison of all details of laboratory procedures are vital tools in standardization efforts. A laboratory protocol that included quality requirements and rejection criteria was developed and proved to be indispensable. The experience gained should be useful in standardizing inter-laboratory results in similar studies.     

Child Life Workers: Who Are They and What Are They Doing?

The survey responses from 152 U S and Canadian Child Life Programs are presented to describe the backgrounds of Child Life workers and the services they are currently offering to pediatric patients and their families The majority of Child Life workers tend to be females with training in Child Development, Education, or Recreation Therapy Although there is variation between Child Life Programs versus those with other titles the “core” activities of Child Life workers tend to be supervising the activity room, preparing patients/families for medicai and surgical procedures, and attending interdisciplinary meetings The survey findings are used to raise questions for consideration in the further development of the Child Life profession.     

Hypomagnesaemia in diabetes

The plasma magnesium (Mg) concentrations of 582 unselected diabetic outpatients and 140 control subjects were measured by atomic absorption spectrophotometry. Mean plasma Mg (+/-S.D.) was significantly lower in the diabetic patients (0.737 +/- 0.071 mmol/l) than in the control subjects (0.810 +/- 0.057 mmol/l), and 146 (25%) diabetics had values below those of all control subjects except one. Plasma Mg correlated best with clinic blood glucose concentration (r = -0.32, p less than 0.001) and other significant associations were observed with glycosuria, age, sex, insulin therapy and biguanide therapy. Although its significance is unclear, hypomagnesaemia could conceivably predispose to ischaemic heart disease in diabetes.