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Hiroko Hagiwara Yuko Fujita Tamaki Ishima Shinsui Kunitachi Yukihiko Shirayama Masaomi Iyo Kenji Hashimoto 《European neuropsychopharmacology》2008,18(6):448-454
Accumulating evidence suggests that the serotonin 5-HT1A receptor may play a role in the pathophysiology of schizophrenia. The present study was undertaken to examine the effects of perospirone, an atypical antipsychotic drug with 5-HT1A receptor agonism, on cognitive deficits in mice after repeated administration of the NMDA receptor antagonist phencyclidine (PCP). Subsequent subchronic (14 days) administration of perospirone (1.0, 3.0, or 10 mg/kg) significantly attenuated PCP (10 mg/kg)-induced cognitive deficits in mice, in a dose-dependent manner. The effects of perospirone (10 mg/kg) were significantly antagonized by co-administration of the selective 5-HT1A receptor antagonist WAY100635 (1.0 mg/kg). Furthermore, hypothermia by the 5-HT1A receptor agonist 8-OH DPAT (0.25 mg/kg) was significantly attenuated in mice treated with PCP. Moreover, a receptor binding assay using [3H]WAY100635 revealed that levels of 5-HT1A receptors in the hippocampus, but not in the frontal cortex, of PCP-treated mice were significantly lower than those of saline-treated mice. These findings suggest that repeated PCP administration alters 5-HT1A receptor function in the mouse brain, and that subsequent subchronic administration of perospirone ameliorates PCP-induced cognitive deficits via 5-HT1A receptors. Therefore, perospirone could be a potential therapy for the cognitive deficits observed in schizophrenic patients. 相似文献
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Nishi Hiroshi; Tojo Akihiro; Onozato Maristela Lika; Jimbo Rika; Nangaku Masaomi; Uozaki Hiroshi; Hirano Kenji; Isayama Hiroyuki; Omata Masao; Kaname Shinya 《Nephrology, dialysis, transplantation》2007,22(5):1491
Nephrol Dial Transplant 2007; 22: 12731275; 相似文献
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OBJECTIVE: Inadequate supraspinal modulation of spinal motor control mechanisms such as alpha-gamma coactivation is supposed to cause difficulty in maintaining proper voluntary contraction in Parkinson's disease (PD). METHODS: Subjects were 42 patients with PD and 20 normal volunteers. Soleus H-reflex and tendon tap reflex (T-reflex) were recorded. The maximal reflexes (H(max) and T(max)) at rest were recorded first. Next, the stimulus intensities were fixed to obtain a reflex size of around 25% of M(max) at rest for both H- and T-reflexes, and the reflexes were recorded at rest, during tonic plantarflexion (TPF), and at the onset of plantarflexion. RESULTS: H(max) at rest was 55% and T(max) 30% in normal subjects, while they were 36 and 31%, respectively, in PD. The size ratio of T(max) and H(max) at rest in PD was larger than normal. In PD, the size of H-reflex increased with TPF as in normal subjects, but T-reflex decreased. These changes in T-reflex were correlated with the grade of rigidity, bradykinesia, and time for 10 m gait. H-reflex had no such correlations. CONCLUSIONS: T-reflex was abnormally modulated in PD especially during tonic contraction. SIGNIFICANCE: Inappropriate supraspinal modulation of the spinal reflex pathways disturbs motor performance in PD. 相似文献
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Y. Maeda K. Yamada T. Hasegawa M. Iyo S. Fukui T. Nabeshima 《Journal of neural transmission (Vienna, Austria : 1996)》1994,96(2):125-133
Summary We have examined the effects of salmon calcitonin (SCT), injected into the cerebral ventricle (i.c.v.), on the tail-biting and scratching behavior induced by the intrathecal injection of different types of nociceptive agents, i.e., substance P, N-methyl-D-aspartate (NMDA), kainate (KA), and quisqualate (Quis). Tail-biting and scratching behavior induced by the 4 substances was significantly inhibited by SCT (i.c.v.) in the same manner: the dose-response curves were U-shaped, and the most effective dose was O.lIU/mouse in all cases. SCT did not, however, completely inhibit tail-biting and scratching behavior. At its most effective dose, the percent inhibition of substance P-, NMDA-, KA- and Quis-induced behavior were 77.9%, 40.2%, 49.4%, and 52.9%, respectively. These results suggest that SCT has the inhibitory effects of substance P- and glutamate receptor agonists-induced nociceptive response in vivo. 相似文献
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Identification of candidate genes involved in the etiology of sporadic Tourette syndrome by exome sequencing 下载免费PDF全文
Yosuke Eriguchi MD PhD Hitoshi Kuwabara MD PhD Aya Inai MD Yuki Kawakubo PhD Fumichika Nishimura MD PhD Chihiro Kakiuchi MD PhD Mamoru Tochigi MD PhD Jun Ohashi PhD Naoto Aoki MD PhD Kayoko Kato PhD Hiroyuki Ishiura MD PhD Jun Mitsui MD PhD Shoji Tsuji MD PhD Koichiro Doi PhD Jun Yoshimura PhD Shinichi Morishita PhD Takafumi Shimada MD PhD Masaomi Furukawa MD Tadashi Umekage MD PhD Tsukasa Sasaki MD PhD Kiyoto Kasai MD PhD Yukiko KanoMD PhD MD PhD 《American journal of medical genetics. Part B, Neuropsychiatric genetics》2017,174(7):712-723