Combined use of reminyl (galanthamine) and ovestin (oestradiol) for the treatment of cognitive disorders in women with hypoestrogenic syndrome

The efficacy of a combined therapy with reminyl and ovestin in low doses used for pharmacocorrection of cognitive disorders in women after total ovariectomy has been studied. The results show a pronounced efficacy of the proposed combined therapy as compared to the standard hormonal replacement therapy in women with hypoestrogenic syndrome, which is confirmed by a significant decrease in the expression of mental impairments evaluated using the BCRS, CCSE, and MMSE methods.     

放射医学实习医生实际工作能力的培养

放射诊断实习是使影像学实习生成长为放射诊断专业人才的一个重要阶段,是实现理论与实践结合的重要教学实践模式。提高放射诊断实习质量,增强医学影像专业实习生的有关临床能力是临床教学中值得重视和思考的问题。丰富的学习资源,强调影像表现与临床、病理相结合以及X线、CT、MRI并重,加强阅片和操作技能的培养,强调临床辩证思维等方法有助于改善和提高放射诊断临床教学质量。     

Buruli ulcer in Malawi - a first report

One hundred and sixty-one specimens swabbed from as many patients with chronic wounds/ulcers over a period of eight months yielded 3 acid-alcohol fast bacilli (AFB) organisms that slowly grew only at 32°C on Lowenstein-Jensen(LJ) medium producing creamy-yellow colonies between 39 and 45 days post-incubation. Mycobacterial organisms harvested from culture were strongly positive when subjected to both catalase spot test and catalase heat stability test indicating the presence of Mycobacterium ulcerans, the aetiological agent of Buruli ulcer.     

The successful immune response against hepatitis C nonstructural protein 5A (NS5A) requires heterologous DNA/protein immunization

The aim of this study was to evaluate the immunogenicity of NS5A protein of human hepatitis C virus (HCV) when delivered as naked DNA (NS5A DNA), or recombinant protein (rNS5A). DBA/2J mice received NS5A DNA, rNS5A, or NS5A DNA/rNS5A in different prime-boost combinations with a peptidoglycan Immunomax^®. The weakest response was induced after rNS5A prime and NS5A DNA boost; rNS5A alone induced an immune response with a strong Th2-component; and NS5A DNA alone, a relatively weak secretion of IL-2 and IFN-γ. The most efficient was co-injection of NS5A DNA and rNS5A, which induced a significant increase in CD4⁺ and CD8⁺ T-cell counts, anti-NS5A antibodies, specific T-cell proliferation, and proinflammatory cytokine production in vitro against a broad spectrum of NS5A epitopes. Administration of the mixture of adjuvanted DNA and protein immunogens can be selected as the best regimen for further preclinical HCV-vaccine trials.