全文获取类型
收费全文 | 2593篇 |
免费 | 181篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 35篇 |
儿科学 | 73篇 |
妇产科学 | 112篇 |
基础医学 | 352篇 |
口腔科学 | 38篇 |
临床医学 | 420篇 |
内科学 | 478篇 |
皮肤病学 | 38篇 |
神经病学 | 275篇 |
特种医学 | 45篇 |
外科学 | 226篇 |
综合类 | 25篇 |
一般理论 | 2篇 |
预防医学 | 316篇 |
眼科学 | 74篇 |
药学 | 135篇 |
中国医学 | 3篇 |
肿瘤学 | 140篇 |
出版年
2023年 | 14篇 |
2022年 | 32篇 |
2021年 | 79篇 |
2020年 | 44篇 |
2019年 | 50篇 |
2018年 | 73篇 |
2017年 | 50篇 |
2016年 | 67篇 |
2015年 | 77篇 |
2014年 | 99篇 |
2013年 | 150篇 |
2012年 | 187篇 |
2011年 | 196篇 |
2010年 | 99篇 |
2009年 | 108篇 |
2008年 | 152篇 |
2007年 | 157篇 |
2006年 | 182篇 |
2005年 | 162篇 |
2004年 | 164篇 |
2003年 | 156篇 |
2002年 | 138篇 |
2001年 | 12篇 |
2000年 | 17篇 |
1999年 | 20篇 |
1998年 | 28篇 |
1997年 | 19篇 |
1996年 | 16篇 |
1995年 | 16篇 |
1994年 | 12篇 |
1993年 | 13篇 |
1992年 | 12篇 |
1991年 | 13篇 |
1990年 | 10篇 |
1989年 | 13篇 |
1988年 | 11篇 |
1987年 | 7篇 |
1986年 | 8篇 |
1985年 | 8篇 |
1984年 | 16篇 |
1983年 | 15篇 |
1982年 | 10篇 |
1981年 | 7篇 |
1980年 | 10篇 |
1979年 | 5篇 |
1978年 | 5篇 |
1977年 | 5篇 |
1976年 | 10篇 |
1974年 | 6篇 |
1967年 | 6篇 |
排序方式: 共有2787条查询结果,搜索用时 281 毫秒
71.
72.
73.
Narain S Richards HB Satoh M Sarmiento M Davidson R Shuster J Sobel E Hahn P Reeves WH 《Archives of internal medicine》2004,164(22):2435-2441
BACKGROUND: Most individuals with autoimmune and other immune disorders undergo initial evaluation in the community setting. Since misdiagnosis of systemic autoimmune diseases can have serious consequences, we evaluated community physicians' accuracy in diagnosing autoimmune diseases and the consequences of misdiagnosis. METHODS: We studied the patients referred to our Autoimmune Disease Center for 13 months (n = 476). We estimated the degree of agreement with the final diagnosis (kappa statistic) and the accuracy indexes (sensitivity, specificity, and predictive values) of the referring physicians' diagnoses. RESULTS: We found a 49% agreement between the referring and final diagnoses (kappa = 0.36). Of 263 patients referred with a presumptive diagnosis of systemic lupus erythematosus (SLE), 125 received a diagnosis of other conditions (kappa = 0.34). Of those referred with SLE, 76 (29%) were seropositive for antinuclear antibodies but did not have autoimmune disease. The degree of agreement for referring rheumatologists (kappa = 0.55) was better than that for nonrheumatologists (kappa = 0.32). Stepwise logistic regression indicated that rheumatologists were 4 times more likely to make an accurate diagnosis of SLE than were nonrheumatologists (P<.003). Thirty-nine patients who were seropositive for antinuclear antibodies but had no autoimmune disease had been treated with corticosteroids at dosages as high as 60 mg/d. CONCLUSIONS: Many patients with a positive antinuclear antibody test are incorrectly given a diagnosis of SLE and sometimes treated with toxic medications. The data support the importance of continuing medical education for community physicians in screening for autoimmune diseases and identifying patients who may benefit from early referral to a specialist. 相似文献
74.
75.
76.
77.
Jane Topolovec-Vranic Marlene Santos Andrew J Baker Orla M Smith Karen EA Burns 《Canadian respiratory journal》2014,21(5):293-296
INTRODUCTION:
Alterations from first-party and surrogate decision-maker consent can enhance the feasibility of research involving critically ill patients.OBJECTIVE:
To describe the use of a deferred-consent model to enable participation of critically ill patients in a minimal-risk biomarker study.METHODS:
A prospective observational study was conducted in which serum biomarker samples were collected three times daily over the first 14 days following aneurysmal subarachnoid hemorrhage. Sample collection was initiated on intensive care unit admission and consent was obtained when research personnel could approach the patient or the patient’s surrogate decision maker.RESULTS:
Twenty-seven patients were eligible for the study, of whom only five were capable of providing informed consent. Full consent was obtained for 21 (78%) patients through self- (n=4) and surrogate (n=17) consent. Partial consent or refusal (only permitting the collection of blood samples as a part of routine care or use of data) occurred in three patients. Among the 22 consents sought from surrogates, three (11%) refused participation. The refusals included the sickest patients in the cohort. Once consent was provided, no patient or surrogate withdrew consent before study completion.DISCUSSION:
Use of a deferred consent model enabled participation of critically ill patients in a minimal-risk biomarker study with no withdrawals.CONCLUSIONS:
Further research and enhanced awareness of the potential utility of hybrid models, including deferred consent in addition to patient or surrogate consent, in the conduct of low-risk and minimally interventional time-sensitive studies of critically ill patients are required. 相似文献78.
Débora Afonso Silva Rocha Ivone de Andrade Rosa Wanderley de Souza Marlene Benchimol 《Parasitology research》2014,113(3):1041-1047
Trichomonas vaginalis causes trichomoniasis in humans, a sexually transmitted disease commonly treated with metronidazole (MTZ). MTZ is known to cause undesirable side effects, and MTZ-resistant parasites have been reported. Thus, the development of an alternative treatment is desirable. Miltefosine (MLT) is an alkylphosphocholine synthetic lipid analogue that displays antiparasitic activity against Leishmania, Trypanosoma cruzi, Entamoeba histolytica, Acanthamoeba spp., Giardia lamblia, T. vaginalis and some fungi. Moreover, it has been used for oral treatment of visceral leishmaniosis in several countries. Here, we analysed the MLT-induced antiproliferative effect on T. vaginalis as well its effect on the fine structure and viability of the parasite. We observed a dose-dependent effect with an IC50 of 14.5 and 20 μM after 24 and 48 h, respectively. Furthermore, reversibility assays demonstrated that new incubations were necessary in order to maintain the antiproliferative effect. Ultrastructural analyses demonstrated that MLT induced several alterations, including the appearance of wrinkled and rounded cells, membrane blebbing, intense vacuolization and nuclear condensation, all indicative of cell death by apoptosis. In addition, the quantitative analyses of the viability assays using combined markers of live and dead cells demonstrated that treatment with the IC50 concentration of MLT significantly reduced the number of viable parasites compared with untreated cells. Taken together, these observations suggest that MLT is a promising compound for the treatment of trichomoniasis. 相似文献
79.