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71.
Associations between ambient air pollution and daily mortality among persons with congestive heart failure 总被引:5,自引:0,他引:5
Goldberg MS Burnett RT Valois MF Flegel K Bailar JC Brook J Vincent R Radon K 《Environmental research》2003,91(1):8-20
We conducted a mortality time series study to investigate the association between daily mortality for congestive heart failure (CHF), and daily concentrations of particles and gaseous pollutants in the ambient air of Montreal, Quebec, during the period 1984-1993. In addition, using data from the universal Quebec Health Insurance Plan, we identified individuals >/=65 years of age who, one year before death, had a diagnosis of CHF. Fixed-site air pollution monitors in Montreal provided daily mean levels of pollutants. We regressed the logarithm of daily counts of mortality on the daily mean levels of each pollutant, after accounting for seasonal and subseasonal fluctuations in the mortality time series, non-Poisson dispersion, weather variables, and other gaseous and particle pollutants. Using cause of death information, we did not find any associations between daily mortality for CHF and any air pollutants. The analyses of CHF defined from the medical record showed positive associations with coefficient of haze, the extinction coefficient, SO(2), and NO(2). For example, the mean percent increase in daily mortality for an increase in the coefficient of haze across the interquartile range was 4.32% (95% CI: 0.95-7.80%) and for NO(2) it was 4.08% (95% CI: 0.59-7.68%). These effects were generally higher in the warm season. 相似文献
72.
Michel Broyer Geneviève Guest Marie-France Gagnadoux Daniel Beurton 《International urology and nephrology》2001,33(4):691-695
Publications Received
Geriatric nephrology and urology literature 相似文献73.
PROMOTIONOFINVITROGROWTHOFHUMANMEDULLOBLASTOMACELLSBYEXOGENEOUSIL-6LiuJiai刘佳;LiHong李宏;HamouMarie-France;NicolasdeTribolet(1Di... 相似文献
74.
Nathalie Auger Mark Daniel Bärbel Knäuper Marie-France Raynault Barry Pless 《BMC pediatrics》2011,11(1):26
Background
How youth perceive marketing messages in sports is poorly understood. We evaluated whether youth perceive that the imagery of a specific sports marketing advertisement contained smoking-related messages. 相似文献75.
Gülmez D Woodford N Palepou MF Mushtaq S Metan G Yakupogullari Y Kocagoz S Uzun O Hascelik G Livermore DM 《International journal of antimicrobial agents》2008,31(6):523-526
Treatment options are limited in infections caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae, with carbapenems generally preferred. Disturbingly, however, carbapenem-resistant strains are emerging worldwide. Here we report two clinical isolates, one Escherichia coli and one Klebsiella pneumoniae, each with high-level carbapenem resistance (imipenem minimum inhibitory concentration of 32 microg/mL). They were isolated following imipenem therapy from two hospital patients who had received imipenem therapy in different regions of Turkey. Both isolates produced OXA-48-like carbapenemases, enzymes so far reported only from Turkey. Both isolates also had group 1 CTX-M-type ESBLs and had lost major outer membrane proteins. OXA-48-like carbapenemases appear to be scattered in Turkey and surveillance to determine their prevalence is warranted. 相似文献
76.
白血病抑制因子反义寡核苷酸对髓母细胞体外生长的抑制作用 总被引:2,自引:0,他引:2
为进一步认识白血病抑制因子(LIF)对人髓母细胞瘤生长的生物学作用,我们使用LIF反义寡核苷酸,在髓母细胞内特异性阻断LIF基因表达并观察它对靶细胞的生物学效应。结果发现,被处理细胞的LIF表达降低至RT/PCR检出的阈值之下,抗LIF的免疫组织化学染色亦呈阴性,同时,这些细胞的生长速度明显减缓。相反,用与反义寡核苷酸互补的正义序列处理的细胞无论在基因表达/产生,还是在生长速度方面,均和正常培养细胞的细胞相似,本研究从而提示了一条以LIF为对象的髓母细胞瘤以及其它LIF生长依赖性肿瘤的基因和免疫治疗途径。 相似文献
77.
Saugier-Veber P Bonnet C Afenjar A Drouin-Garraud V Coubes C Fehrenbach S Holder-Espinasse M Roume J Malan V Portnoi MF Jeanne N Baumann C Héron D David A Gérard M Bonneau D Lacombe D Cormier-Daire V Billette de Villemeur T Frébourg T Bürglen L 《Human mutation》2007,28(11):1098-1107
Sotos syndrome is an overgrowth syndrome characterized by distinctive facial features, learning difficulties, and macrocephaly with frequent pre- and postnatal overgrowth with advanced bone age. Here, we report on our experience in the molecular diagnostic of Sotos syndrome on 116 patients. Using direct sequencing and a quantitative multiplex PCR of short fluorescent fragments (QMPSF)-based assay allowing accurate detection of both total and partial NSD1 deletions, we identified NSD1 abnormalities in 104 patients corresponding to 102 Sotos families (90%). NSD1 point mutations were detected in 80% of the index cases, large deletions removing the NSD1 gene entirely in 14%, and intragenic NSD1 rearrangements in 6%. Among the 69 detected distinct point mutations, 48 were novel. The QMPSF assay detected an exonic duplication and a mosaic partial deletion. QMPSF mapping of the 15 large deletions revealed the heterogeneity of the deletions, which vary in size from 1 to 4.5 Mb. Clinical features of NSD1-positive Sotos patients revealed that the phenotype in patients with nontruncating mutations was less severe that in patients with truncating mutations. This study confirms the heterogeneity of NSD1 alterations in Sotos syndrome and therefore the need to complete sequencing analysis by screening for partial deletions and duplications to ensure an accurate molecular diagnosis of this syndrome. 相似文献
78.
Bertrand MF Semez G Leforestier E Muller-Bolla M Nammour S Rocca JP 《Lasers in surgery and medicine》2006,38(6):615-623
BACKGROUND AND OBJECTIVES: The purpose of this study was to assess the performances of a single-component adhesive system when an Er:YAG laser was used to prepare cavities. STUDY DESIGN/MATERIALS AND METHODS: Shear bond strength tests were performed on composite rods bonded with a single-component adhesive system to dentin surfaces prepared using either bur+acid, Er:YAG laser (fluence = 44 J/cm2), or Er:YAG laser+acid. Class V cavities were prepared differently according to the molar surface: buccal surfaces were prepared using a diamond bur, and lingual surfaces using the Er:YAG laser. In group 1, cavity walls were not acid treated after Er:YAG laser preparation. In group 2, only the enamel walls were acid treated. In group 3, all the enamel and dentin walls were acid treated. Microleakage was assessed using a methylene blue dye penetration method. RESULTS: Bond strength values did not differ significantly between the three groups (P = 0.162). Better marginal adaptation was obtained between the composite resin and cavity walls when Er:YAG laser preparation was followed by a total acid etching (P = 0.008). CONCLUSIONS: Our results supported the use of single-component adhesive systems in cavities prepared using Er:YAG laser. The step of acid etching must be maintained for the whole cavity walls in regard of the microleakage values. 相似文献
79.
James G. Malone-Lee MD J. Bernard Walsh Marie-France Maugourd the Tolterodine in the Elderly Study Group 《Journal of the American Geriatrics Society》2001,49(6):700-705
OBJECTIVE: To investigate the clinical safety and efficacy of two dosages of tolterodine in older patients with symptoms attributable to overactive bladder. DESIGN: Randomized, double-blind, placebo-controlled, parallel-group, multinational, phase III study. SETTING: Incontinence, older care, urological, and urogynecological clinics in the United Kingdom, France, and the Republic of Ireland. PARTICIPANTS: One hundred and seventy-seven older patients (age > or =65 years) with symptoms of urinary urgency, increased frequency of micturition (> or =8 micturitions/24 hours), and/or urge incontinence (> or =1 episode/24 hours). INTERVENTION: Tolterodine 1 mg or 2 mg twice daily (bid), or placebo, for 4 weeks. MEASUREMENTS: Safety and tolerability were evaluated through spontaneously reported adverse events, electrocardiogram, and blood pressure measurements. Efficacy was assessed using micturition diary variables: mean change from baseline in frequency of micturition and number of incontinence episodes/24 hours. RESULTS: The mean age of the patient population was 75 years. Overall, > or =87% of patients completed the study. Neither dosage of tolterodine was associated with serious drug-related adverse events during the study. No cardiac arrythmogenic events were noted. Dry mouth (mild to moderate intensity) was the most common adverse event in both the placebo and tolterodine treatment groups. Three percent of patients in the tolterodine 2 mg bid group discontinued treatment because of dry mouth, compared with 2% of placebo-treated patients. Compared with placebo, statistically significant decreases in micturition frequency were apparent in both tolterodine treatment groups. Furthermore, patients treated with tolterodine 2 mg bid had statistically significant decreases in urge incontinence episodes/24 hours and increases in volume voided per micturition compared with placebo. CONCLUSION: Tolterodine (taken for 4 weeks) is safe and shows efficacy, particularly at a dosage of 2 mg bid, in the treatment of older patients with urinary symptoms attributable to overactive bladder. 相似文献
80.
Marie-Paule Beaujard Sandra Chantot Michle Dubois Boris Keren Wassila Carpentier Philippe Mabboux Sandra Whalen Michel Vodovar Jean-Pierre Siffroi Marie-France Portnoï 《European journal of medical genetics》2009,52(5):321-327
Despite the heterogeneous clinical presentations, the majority of patients with 22q11.2 deletion syndrome (22q11.2 DS) have either a common recurrent 3 Mb deletion or a less common, 1.5 Mb nested deletion, with breakpoint sites in flanking low-copy repeats (LCR) sequences. Only a small number of atypical deletions have been reported and precisely defined. Haploinsufficiency of the TBX1 gene was determined to be the likely cause of 22q11.2 DS. The diagnostic procedure usually used is FISH using commercially probes (N25 or TUPLE1). However, this test does not contain TBX1, and fails to detect deletions that are either proximal or distal to the FISH probes. Here, we report on two patients with clinical features suggestive of 22q11.2 DS, a male infant with facial dysmorphia, pulmonary atresia, ventricular septal defect, neonatal hypocalcemia, and his affected mother, with facial dysmorphia, learning disabilities, and hypernasal speech. They were tested negative for 22q11.2 DS using N25 or TUPLE1 probes, but were shown deleted for a probe containing TBX1. Delineation of the deletion was performed using high-density SNP arrays (Illumina, 370K). This atypical deletion was spanning 1.89 Mb. The distal breakpoint resided in LCR-D, sharing the same distal breakpoint with the 3 Mb common deletion. The proximal breakpoint was located 105 kb telomeric to TUPLE1, representing a new breakpoint variant that does not correspond to known LCRs of 22q11.2. We conclude that FISH with the TBX1 probe is an accurate diagnostic tool for 22q11.2 DS, with a higher sensitivity than FISH using standard probes, detecting all but the rarest deletions, greatly reducing the false negative rate. 相似文献