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Role of adult bone marrow stem cells in the repair of ischemic myocardium: current state of the art 总被引:2,自引:0,他引:2
Charwat S Gyöngyösi M Lang I Graf S Beran G Hemetsberger R Nyolczas N Sochor H Glogar D 《Experimental hematology》2008,36(6):672-680
OBJECTIVE: To review the milestones in stem cell therapy for ischemic heart disease from early basic science to large clinical studies and new therapeutic approaches. MATERIALS AND METHODS: Basic research and clinical trials (systematic review) were used. The heart has the ability to regenerate through activation of resident cardiac stem cells or through recruitment of a stem cell population from other tissues, such as bone marrow. Although the underlying mechanism is yet to be made clear, numerous studies in animals have documented that transplantation of bone marrow-derived stem cells or circulating progenitor cells following acute myocardial infarction and ischemic cardiomyopathy is associated with a reduction in infarct scar size and improvements in left ventricular function and myocardial perfusion. RESULTS: Cell-based cardiac therapy has expanded considerably in recent years and is on its way to becoming an established cardiovascular therapy for patients with ischemic heart disease. There have been recent insights into the understanding of mechanisms involved in the mobilization and homing of the imported cells, as well as into the paracrine effect, growth factors, and bioactive molecules. Additional information has been obtained regarding new stem cell sources, cell-based gene therapy, cell-enhancement strategies, and tissue engineering, all of which should enhance the efficacy of human cardiac stem cell therapy. CONCLUSIONS: The recently published trials using bone marrow-origin stem cells in cardiac repair reported a modest but significant benefit from this therapy. Further clinical research should aim to optimize the cell types utilized and their delivery mode, and pinpoint optimal time of cell transplantation. 相似文献
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Radiosurgery versus open surgery for mesial temporal lobe epilepsy: The randomized,controlled ROSE trial
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Nicholas M. Barbaro Mark Quigg Mariann M. Ward Edward F. Chang Donna K. Broshek John T. Langfitt Guofen Yan Kenneth D. Laxer Andrew J. Cole Penny K. Sneed Christopher P. Hess Wei Yu Manjari Tripathi Christianne N. Heck John W. Miller Paul A. Garcia Andrew McEvoy Nathan B. Fountain Vincenta Salanova Robert C. Knowlton Anto Bagić Thomas Henry Siddharth Kapoor Guy McKhann Adriana E. Palade Markus Reuber Evelyn Tecoma 《Epilepsia》2018,59(6):1198-1207
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Long-term exposure of male mice to inorganic lead (lead chloride, 1 g/liter) in the drinking water reduces their fertility. The cause of this reduction, expressed as a decrease in the number of mated females showing implantations, was investigated, using an in vitro fertilization method. It was found that spermatozoa from lead-exposed males had a significantly lower ability to fertilize mouse eggs than those from unexposed males. Preimplantation embryos, isolated from uterine horns of mice mated with lead-exposed males, were examined. No morphologically abnormal embryos were found. However, when cultured in vitro over the implantation period, blastocysts of the group mated with lead-exposed males showed an increased frequency of delayed hatching from the zona pellucida or an inability to hatch. Among blastocysts from this group a decreased frequency of inner cell mass development was also found. 相似文献
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Abbas Ali Qayyum Bas van Klarenbosch Sabina Frljak Andraz Cerar Gregor Poglajen Denise Traxler-Weidenauer Pawel Nadrowski Christina Paitazoglou Bojan Vrtovec Martin W. Bergmann Steven A. J. Chamuleau Wojtek Wojakowski Mariann Gyöngyösi Adriaan Kraaijeveld Kristian Schultz Hansen Karsten Vrangbæk Erik Jørgensen Steffen Helqvist Francis Richard Joshi Ellen Mønsted Johansen Bjarke Follin Morten Juhl Lisbeth Drozd Højgaard Anders Bruun Mathiasen Annette Ekblond Mandana Haack-Sørensen Jens Kastrup the SCIENCE Investigators 《European journal of heart failure》2023,25(4):576-587